Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Valérie Guyot"'
Autor:
Agnes Gouble, Roman Galetto, Cécile Schiffer-Mannioui, Sophie Leduc, Isabelle Chion-Sotinel, Diane le Clerre, Valérie Guyot, Marco Rotondi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/c92e43cc8cdd42c7bddaa15ec507f2a7
Autor:
Anne-Sophie Gautron, Alexandre Juillerat, Valérie Guyot, Jean-Marie Filhol, Emilie Dessez, Aymeric Duclert, Philippe Duchateau, Laurent Poirot
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 312-321 (2017)
Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of “off-the-shelf” CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC). Taki
Externí odkaz:
https://doaj.org/article/64994fa029a0484386e24c93061ea7fd
Autor:
Christophe Perez, Valérie Guyot, Jean-Pierre Cabaniols, Agnès Gouble, Beatrice Micheaux, Julie Smith, Sophie Leduc, Frédéric Pâques, Philippe Duchateau
Publikováno v:
BioTechniques, Vol 39, Iss 1, Pp 109-115 (2005)
Double-strand break (DSB)-induced homologous recombination (HR) of direct repeats is a powerful means to achieve gene excision, a critical step in genome engineering. In this report we have used an extrachromosomal reporter system to monitor the impa
Externí odkaz:
https://doaj.org/article/1580e8c8425a4d9fae731c0d79632b5f
Autor:
Fabien Delacôte, Christophe Perez, Valérie Guyot, Marianne Duhamel, Christelle Rochon, Nathalie Ollivier, Rachel Macmaster, George H Silva, Frédéric Pâques, Fayza Daboussi, Philippe Duchateau
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53217 (2013)
Targeting DNA double-strand breaks is a powerful strategy for gene inactivation applications. Without the use of a repair plasmid, targeted mutagenesis can be achieved through Non-Homologous End joining (NHEJ) pathways. However, many of the DNA break
Externí odkaz:
https://doaj.org/article/f3cd0e8d8ff24ecf88c47733d9ec4918
Autor:
Fabien Delacôte, Christophe Perez, Valérie Guyot, Catherine Mikonio, Pierrick Potrel, Jean-Pierre Cabaniols, Christophe Delenda, Frédéric Pâques, Philippe Duchateau
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
Homologous gene targeting (HGT) is a precise but inefficient process for genome engineering. Several methods for increasing its efficiency have been developed, including the use of rare cutting endonucleases. However, there is still room for improvem
Externí odkaz:
https://doaj.org/article/e61488346f9f4760adf94a2ded8d2de9
Autor:
Philippe Duchateau, Alexandre Juillerat, Laurent Poirot, Jean-Marie Filhol, Valérie Guyot, Anne-Sophie Gautron, Emilie Dessez, Aymeric Duclert
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 312-321 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of "off-the-shelf" CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC). Taking a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68015fd77ee2d45fd6f73103cb65ebc
https://doi.org/10.1016/j.omtn.2017.10.005
https://doi.org/10.1016/j.omtn.2017.10.005
Autor:
Cécile Schiffer-Mannioui, Marco Rotondi, Agnès Gouble, Diane Le Clerre, Sophie Leduc, Valérie Guyot, Isabelle Chion-Sotinel, Roman Galetto
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundChimeric Antigen Receptor (CAR) T cell therapy is emerging as a potential treatment for solid tumors, even if only limited activity has been observed for CAR T therapies to date. Cellular therapies face indeed many hurdles in solid tumors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4284e99421313014aa86aabd619325
https://doi.org/10.1136/jitc-2021-sitc2021.143
https://doi.org/10.1136/jitc-2021-sitc2021.143
Autor:
Cesar Sommer, Aymeric Duclert, Alexandre Juillerat, Barbra Sasu, Thomas Pertel, Laurent Poirot, Julien Valton, Valérie Guyot, Bijan Boldajipour, Philippe Duchateau
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report the development of the CubiCAR, a tri-fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0000f0a58f759c5d5674d7a42b7123b7
https://doi.org/10.1038/s41598-018-27264-w
https://doi.org/10.1038/s41598-018-27264-w
Autor:
Laurent Poirot, Julien Valton, Valérie Guyot, Alan Maréchal, Philippe Duchateau, Alexandre Juillerat, Aymeric Duclert, Jean-Marie Filhol
Publikováno v:
Molecular Therapy
The adoptive transfer of chimeric antigen receptor (CAR) T cell represents a highly promising strategy to fight against multiple cancers. The clinical outcome of such therapies is intimately linked to the ability of effector cells to engraft, prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462e768bb2814272cdfde3da51a64111
https://doi.org/10.1038/mt.2015.104
https://doi.org/10.1038/mt.2015.104
Autor:
Christophe Perez, Sylvia Bruneau, Julianne Smith, Laurence Fiette, Patrick Ave, Béatrice Micheau, Frédéric Pâques, Jean-Pierre Cabaniols, Valérie Guyot, Philippe Duchateau, Sophie Leduc, Agnès Gouble
Publikováno v:
The Journal of Gene Medicine. 8:616-622
Background Sequence-specific endonucleases with large recognition sites can cleave DNA in living cells, and, as a consequence, stimulate homologous recombination (HR) up to 10 000-fold. The recent development of artificial meganucleases with chosen s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a74f99e68ef18d25c0cda0c9408985
https://doi.org/10.1002/jgm.879
https://doi.org/10.1002/jgm.879