Výsledky vyhledávání - "Valérie Fritsch"

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Die VerkörperungEN : ein bilderbuch | Roman

Autor: Valerie Fritsch

Paris. Die roten Lichter der Freudenhäuser und die weißen Lichter der Krankenhäuser leuchten in dieser Stadt, wenn es um die Krankheiten und die Genüsse geht, die Gewohnheiten ausbleiben, aber die Abschiede einsetzen. Die Protagonistin, früher H

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SYNTHETIC MODIFICATIONS OF ANTISENSE OLIGONUCLEOTIDES: NOVEL BACKBONE REPLACEMENTS WITH IMPROVED PROPERTIES

Autor: Valérie Fritsch, Adrian Waldner, Romain M. Wolf, Jacques Lebreton, Alain De Mesmaeker

Publikováno v: Bulletin des Sociétés Chimiques Belges. 103:705-717

Eleven different types of backbone replacements have been investigated. The thermodynamic stability of the duplexes formed between these modified oligonucleotides and their RNA complements are summarized. Among these backbone replacements, we identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d275e8be816f282fabfc1771ef436517
https://doi.org/10.1002/bscb.19941031203

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Amide-Modified Oligonucleotides with Preorganized Backbone and Furanose Rings: Highly Increased Thermodynamic Stability of the Duplexes Formed with their RNA and DNA Complements

Autor: Chantal Jouanno, Sebastian Wendeborn, Valérie Fritsch, Romain M. Wolf, Alain De Mesmaeker, Jacques Lebreton

Publikováno v: Synlett. 1997:1287-1290

The amide backbone modification C3'-CH2-CONH-C5' has been further modified by introducing a methyl at C5', either in R or in S configuration. Only the S stereoisomer can adopt the required geometry to fit into a duplex with complementary RNA. Additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c40425666e5154494f6248145281b538
https://doi.org/10.1055/s-1997-1003

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Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

Autor: Chantal Jouanno, Alain De Mesmaeker, Valérie Fritsch, Romain M. Wolf, Sebastian Wendeborn

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:1869-1874

The synthesis of the amide dimers 3–5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5ea8163dea05916f274d56efb25c86a
https://doi.org/10.1016/s0960-894x(97)00318-1

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Molecular mechanics and dynamics studies on two structurally related amide-modified DNA backbones for antisense technology

Autor: Marcel J. J. Blommers, Adrian Waldner, Romain M. Wolf, Jacques Lebreton, Valérie Fritsch, Alain De Mesmaeker

Publikováno v: Bioorganic & Medicinal Chemistry. 3:321-335

The effect of the replacement of the natural phosphodiester linkage -C3'-O-PO2-O-CH2-C4'- in the DNA strand of RNA.DNA hybrid duplexes by either of the two amide linkages -C3'-CH2-CO-NH-CH2-C4'- or -C3'-CH2-NH-CO-CH2-C4' has been investigated by mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97b4c3292c1de1e493be4a54862c85b
https://doi.org/10.1016/0968-0896(95)00029-g

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Comparison of two amides as backbone replacement of the phosphodiester linkage in oligodeoxynucleotides

Autor: Jacques Lebreton, Valérie Fritsch, Romain M. Wolf, Alain De Mesmaeker, Adrian Waldner

Publikováno v: Tetrahedron Letters. 35:5225-5228

The two isomeric amide modifications 1 and 2 show similar effects on the melting temperature of RNA/DNA duplexes, when they replace the natural phosphodiester linkage in the DNA strand. The synthesis of the amide dimer 1 is presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2dc186eb4b284186a983dba3374db998
https://doi.org/10.1016/s0040-4039(00)77069-9

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Replacement of the phosphodiester linkage in oligonucleotides: Comparison of two structural amide isomers

Autor: Jacques Lebreton, Valérie Fritsch, Romain M. Wolf, Adrian Waldner, Alain De Mesmaeker

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:873-878

The two structural amide isomers 2 and 3 as backbone replacement in oligonucleotides lead to very similar results for the binding affinities (Tm) of the duplexes formed with their complementary RNA strands.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c7d992856e86be9498d83160507dcd8
https://doi.org/10.1016/s0960-894x(01)80254-7

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