IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Autor: Yukihide Momozawa, Julia Dmitrieva, Emilie Théâtre, Valérie Deffontaine, Souad Rahmouni, Benoît Charloteaux, François Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cécile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd Bouma, Frank Hoentjen, Mark Löwenberg, Bas Oldenburg, Marieke J. Pierik, Andrea E. vander Meulen-de Jong, C. Janneke van der Woude, Marijn C. Visschedijk, The International IBD Genetics Consortium, Mark Lathrop, Jean-Pierre Hugot, Rinse K. Weersma, Martine De Vos, Denis Franchimont, Severine Vermeire, Michiaki Kubo, Edouard Louis, Michel Georges

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulator

Externí odkaz: https://doaj.org/article/c3282316b00248958032424db0e3a0c7

Fine-mapping inflammatory bowel disease loci to single-variant resolution

Autor: Rob Mariman, Jo Knight, Charlie W. Lees, Ann-Stephan Gori, Mahmoud Elansary, Michel Georges, Gabrielle Boucher, Isabelle Cleynen, Rinse K. Weersma, Talin Haritunians, John D. Rioux, Suzanne van Sommeren, Valérie Deffontaine, Mauro D'Amato, Theo Meuwissen, Philippe Goyette, Hailiang Huang, Richard H. Duerr, François Crins, Ming Fang, Emilie Theatre, Andre Franke, Julia Dmitrieva, Maša Umićević Mirkov, Severine Vermeire, Gosia Trynka, Myriam Mni, Elisa Docampo, Judy H. Cho, Yukihide Momozawa, Edouard Louis, Jack Satsangi, Adrian Cortes, Ian C. Lawrance, Christopher G Mathew, Dermot P.B. McGovern, Jeffrey C. Barrett, Mark J. Daly, Kyle Kai-How Farh, Sarah L. Spain, Vibeke Andersen, Luke Jostins, Miles Parkes, Ramnik J. Xavier, Jonas Halfvarson, Carl A. Anderson

Publikováno v: Huang, H, Fang, M, Jostins, L, Umićević Mirkov, M, Boucher, G, Anderson, C A, Andersen, V, Cleynen, I, Cortes, A, Crins, F, D'Amato, M, Deffontaine, V, Dmitrieva, J, Docampo, E, Elansary, M, Farh, K K-H, Franke, A, Gori, A-S, Goyette, P, Halfvarson, J, Haritunians, T, Knight, J, Lawrance, I C, Lees, C W, Louis, E, Mariman, R, Meuwissen, T, Mni, M, Momozawa, Y, Parkes, M, Spain, S L, Théâtre, E, Trynka, G, Satsangi, J, van Sommeren, S, Vermeire, S, Xavier, R J, Weersma, R K, Duerr, R H, Mathew, C G, Rioux, J D, McGovern, D P B, Cho, J H, Georges, M & Daly, M J & Barrett, J C 2017, ' Fine-mapping inflammatory bowel disease loci to single-variant resolution ', Nature, vol. 547, no. 7662, pp. 173-178 . https://doi.org/10.1038/nature22969
Huang, H, Fang, M, Jostins, L, Umićević Mirkov, M, Boucher, G, Anderson, C A, Andersen, V, Cleynen, I, Cortes, A, Crins, F, D'Amato, M, Deffontaine, V, Dmitrieva, J, Docampo, E, Elansary, M, Farh, K K-H, Franke, A, Gori, A-S, Goyette, P, Halfvarson, J, Haritunians, T, Knight, J, Lawrance, I C, Lees, C W, Louis, E, Mariman, R, Meuwissen, T, Mni, M, Momozawa, Y, Parkes, M, Spain, S L, Théâtre, E, Trynka, G, Satsangi, J, van Sommeren, S, Vermeire, S, Xavier, R J, Weersma, R K, Duerr, R H, Mathew, C G, Rioux, J D, McGovern, D P B, Cho, J H, Georges, M, Daly, M J, Barrett, J C & International Inflammatory Bowel Disease Genetics Consortium 2017, ' Fine-mapping inflammatory bowel disease loci to single-variant resolution ', Nature, vol. 547, no. 7662, pp. 173-178 . https://doi.org/10.1038/nature22969
Nature, 547(7662), 173-178. Nature Publishing Group
Nature
2017, ' Fine-mapping inflammatory bowel disease loci to single-variant resolution ', NATURE, vol. 547, no. 7662, pp. 173-178 . https://doi.org/10.1038/nature22969

Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect millions of people worldwide. Genome-wide association studies have identified 200 inflammatory bowel disease-associated loci, but few have been conclusively r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e5320b4e9720fcb8233feefd083e4a
https://hdl.handle.net/11370/c44d1952-4ce6-4ae5-9286-e942c7d078f6

Discongruence of Mhc and cytochrome b phylogeographical patterns in Myodes glareolus (Rodentia: Cricetidae)

Autor: Josef Bryja, Jean-François Martin, Valérie Deffontaine, Johan Michaux, Maxime Galan, Pierre-Jean G. Malé, Nathalie Charbonnel, Jean-François Cosson

Publikováno v: Biological Journal of the Linnean Society. 105:881-899

In the present study, a phylogeographical approach was developed to analyse the influence of selection and history on a major histocompatibility complex (Mhc) class II gene polymorphism in European bank vole (Myodes glareolus) populations. We focused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dce5a5d2910a21a644c5863cd9bb21b
https://doi.org/10.1111/j.1095-8312.2011.01799.x

A relict bank vole lineage highlights the biogeographic history of the Pyrenean region in Europe

Autor: Sabrina Renaud, Michael C. Fontaine, Johan Michaux, Roland Libois, Valérie Deffontaine, Jean-Pierre Quéré, Ronan Ledevin

Publikováno v: Molecular Ecology, 18(11), 2489-2502. Wiley

The Pyrenean region exhibits high levels of endemism suggesting a major contribution to the phylogeography of European species. But, to date, the role of the Pyrenees and surrounding areas as a glacial refugium for temperate species remains poorly ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f5b5673c5c917a1b1c081c5f06b15e
https://doi.org/10.1111/j.1365-294x.2009.04162.x

Association mapping of inflammatory bowel disease loci to single variant resolution

Autor: Vibeke Andersen, Julia Dmitrieva, Michel Georges, Mauro D'Amato, Edouard Louis, Ann-Stephan Gori, Isabelle Cleynen, Emilie Theatre, Carl A. Anderson, Theo Meuwissen, Andre Franke, Jack Satsangi, Adrian Cortes, Suzanne van Sommeren, Dermot P.B. McGovern, Jeffrey C. Barrett, Yukihide Momozawa, Jonas Halfvarson, Talin Haritunians, Elisa Docampo, Valérie Deffontaine, Gosia Trynka, Mark J. Daly, Judy H. Cho, Maša Umićević Mirkov, Richard H. Duerr, Christopher G Mathew, Ian C. Lawrance, Kyle Kai-How Farh, Sarah L. Spain, Hailiang Huang, John D. Rioux, Severine Vermeire, Jo Knight, Luke Jostins, Miles Parkes, Charlie W. Lees, Rob Mariman, Ming Fang, Ramnik J. Xavier, Gabrielle Boucher, Rinse K. Weersma, François Crins, Myriam Mni, Philippe Goyette, Mahmoud Elansary

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disorder that affects millions worldwide. Genome-wide association studies (GWAS) have identified 200 IBD-associated loci, but few have been conclusively resolved to specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268301cfe94e4db6f1e71761fff4dd6a
https://doi.org/10.1101/028688