Quantitative Flow Cytometric Evaluation of Oxidative Stress and Mitochondrial Impairment in RAW 264.7 Macrophages after Exposure to Pristine, Acid Functionalized, or Annealed Carbon Nanotubes

Autor: Odile Sabido, Agathe Figarol, Jean-Philippe Klein, Valérie Bin, Valérie Forest, Jérémie Pourchez, Bice Fubini, Michèle Cottier, Maura Tomatis, Delphine Boudard

Publikováno v: Nanomaterials, Vol 10, Iss 2, p 319 (2020)

Conventional nanotoxicological assays are subjected to various interferences with nanoparticles and especially carbon nanotubes. A multiparametric flow cytometry (FCM) methodology was developed here as an alternative to quantify oxidative stress, mit

Externí odkaz: https://doaj.org/article/c80e2690c96b4c12a07b42f4ad750795

In Vitro Evaluation of P-gp-Mediated Drug–Drug Interactions Using the RPTEC/TERT1 Human Renal Cell Model

Autor: Sonia Saib, Sophie Hodin, Valérie Bin, Edouard Ollier, Xavier Delavenne

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 47:223-233

In vitro evaluation of the P-glycoprotein (P-gp) inhibitory potential is an important issue when predicting clinically relevant drug-drug interactions (DDIs). Located within all physiological barriers, including intestine, liver, and kidneys, P-gp pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9dbff4eb3796c6c0619f77b0cbef58
https://doi.org/10.1007/s13318-021-00744-7

Effects of heparin and derivatives on podocytes: An in vitro functional and morphological evaluation

Autor: Xavier Delavenne, Valérie Bin, Patrick Mismetti, Zhiguo He, Moin A. Saleem, Sophie Hodin, O Sabido, Olivier Delézay

Publikováno v: Delézay, O, Hé, Z, Sabido, O, Hodin, S, Bin, V, Saleem, M, Mismetti, P & Delavenne, X 2019, ' Effects of heparin and derivatives on podocytes : An in vitro functional and morphological evaluation. ', Journal of Cellular Physiology, vol. 234, no. 9, pp. 15438-15449 . https://doi.org/10.1002/jcp.28191

Unfractionated heparin (UFH) and low molecular heparin derivatives (LMWH) display numerous biological properties in addition to their anticoagulant effects. However, due to the physicochemical heterogeneity of these drugs, a better understanding conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e423a23decdc00a43dd843f5d647b2fd
https://doi.org/10.1002/jcp.28191

Étude multiparamétrique de la bio-toxicité et bio-distribution des nanoparticules AGuIX® sur des modèles innovants de cultures 3D MucilAirTM et OncoCilAirTM

Autor: Lucie Sancey, Christophe Mas, Fabien Rossetti, Michèle Cottier, Valérie Bin, Alain Guignandon, François Lux, Jean-Luc Coll, Olivier Tillement, Delphine Boudard, Odile Sabido, Zhiguo He, Samuel Constant

Publikováno v: Morphologie. 105:S22

Introduction et objectifs Le cancer broncho-pulmonaire demeure un probleme de sante publique. Le gold standard du traitement est la chirurgie pouvant etre remplacee et/ou associee a de la radiotherapie. La contrainte principale etant les effets delet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2380d0f3839442dc209aad7dea6e364a
https://doi.org/10.1016/j.morpho.2021.05.043

Quantification of nanoparticle endocytosis based on double fluorescent pH-sensitive nanoparticles

Autor: Valérie Forest, Jérémie Pourchez, Odile Sabido, Valérie Bin, Laurence Marmuse, Andréa Kurtz-Chalot, Jean-Philippe Klein, Michèle Cottier, Delphine Boudard

Publikováno v: Biomedical Microdevices
Biomedical Microdevices, Springer Verlag, 2015, 17 (2), pp.42. ⟨10.1007/s10544-015-9947-8⟩

International audience; Amorphous silica is a particularly interesting material because of its inertness and chemical stability. Silica nanoparticles have been recently developed for biomedical purposes but their innocuousness must be carefully inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8018a8f681762a6a26063368628f090a
https://doi.org/10.1007/s10544-015-9947-8