The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

Autor: Ouada Nebie, David Devos, Valérie Vingtdeux, Lassina Barro, Jean-Christophe Devedjian, Aurélie Jonneaux, Ming-Li Chou, Régis Bordet, Luc Buée, Folke Knutson, David Blum, Thierry Burnouf

Publikováno v: Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-14 (2019)

Abstract Background Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying strategy of neurodegenera

Externí odkaz: https://doaj.org/article/97aeff79cd2146bf9ae7f86807ad013d

AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation

Autor: Claudia Marinangeli, Sébastien Didier, Tariq Ahmed, Raphaelle Caillerez, Manon Domise, Charlotte Laloux, Séverine Bégard, Sébastien Carrier, Morvane Colin, Philippe Marchetti, Bart Ghesquière, Detlef Balschun, Luc Buée, Jérôme Kluza, Valérie Vingtdeux

Publikováno v: iScience, Vol 9, Iss , Pp 1-13 (2018)

Summary: Although the brain accounts for only 2% of the total body mass, it consumes the most energy. Neuronal metabolism is tightly controlled, but it remains poorly understood how neurons meet their energy demands to sustain synaptic transmission.

Externí odkaz: https://doaj.org/article/7580a981d57644c093f4163a9ab04f2b

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Autor: Caroline Evrard, Pascal Kienlen-Campard, Mathilde Coevoet, Rémi Opsomer, Bernadette Tasiaux, Patricia Melnyk, Jean-Noël Octave, Luc Buée, Nicolas Sergeant, Valérie Vingtdeux

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Aβ peptides, the major components of Alzheimer’s disease (AD) amyloid deposits, are released following sequential cleavages by secretases of its precursor named the amyloid precursor protein (APP). In addition to secretases, degradation pathways,

Externí odkaz: https://doaj.org/article/2633ffaf0c1f45a6a5fa8fc69f8a5625

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Autor: Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant

Publikováno v: Neurobiology of Disease, Vol 25, Iss 3, Pp 686-696 (2007)

The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta). Abeta derives from the amyloid p

Externí odkaz: https://doaj.org/article/5a0995a281d244c7b4906161afb967cd

The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

Autor: Lassina Barro, Valérie Vingtdeux, Ouada Nebie, David Blum, Jean Christophe Devedjian, Ming Li Chou, Folke Knutson, Thierry Burnouf, Régis Bordet, Luc Buée, Aurélie Jonneaux, David Devos

Publikováno v: Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-14 (2019)
Journal of Biomedical Science
Journal of Biomedical Science, BioMed Central, 2019, 26 (1), pp.89. ⟨10.1186/s12929-019-0579-9⟩
Journal of Biomedical Science, 2019, 26 (1), pp.89. ⟨10.1186/s12929-019-0579-9⟩

Background Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying strategy of neurodegeneration. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bff42e9111b7fe9aa0d630ec7c1416
http://link.springer.com/article/10.1186/s12929-019-0579-9