Interleukin-31 Signaling Bridges the Gap Between Immune Cells, the Nervous System and Epithelial Tissues

Autor: Jana Maria Nemmer, Marcus Kuchner, Angeliki Datsi, Péter Oláh, Valérie Julia, Ulrike Raap, Bernhard Homey

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Pruritus represents one of the most common symptoms in dermatology and general medicine. Chronic pruritus severely impairs the quality of life of affected patients. During the last two decades a number of modulators and mediator of pruritus have been

Externí odkaz: https://doaj.org/article/03c3aeef63b14dd6add58126d59324d7

Transcriptomics Analysis Indicates Trifarotene Reverses Acne-Related Gene Expression Changes

Autor: Valérie Julia, Jayendra Kumar Krishnaswamy, Rajeev Chavda, Amir Khammari, S. Blanchet‐Réthoré, Brigitte Dréno

Publikováno v: Frontiers in Medicine
Frontiers in Medicine, Vol 8 (2021)

Background and Objectives: Trifarotene is a topical retinoid selective for retinoic acid receptor gamma that was recently approved for treatment of acne vulgaris. We performed a gene expression analysis to identify the molecular and cellular impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e64fc2fc43487908b49d27e3e4395ee
http://europepmc.org/articles/PMC8569320

Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis

Autor: Tan Siyun Lucinda, Charles-Antoine Dutertre, Mark B Y Tang, Satoshi Nakamizo, Josephine Lum, Laurent Yvan-Charvet, Shawn Lim, Feriel Hacini-Rachinel, Geraldine Koh, Florent Ginhoux, Emma Guttman-Yassky, Masashi Iwata, Tsuyoshi Goto, Charlene Foong, Pearly Yong, Kaori Tomari, Reiko Sato, Xiaomeng Zhang, Kenji Kabashima, Rintaro Shibuya, Ahad Khalilnezhad, Valérie Julia, Colin Theng, Kahbing Jasmine Tan, Benoit Malleret, Helen He, Baptiste Janela

Publikováno v: The Journal of experimental medicine. 218(9)

Inflammatory skin diseases including atopic dermatitis (AD) and psoriasis (PSO) are underpinned by dendritic cell (DC)–mediated T cell responses. Currently, the heterogeneous human cutaneous DC population is incompletely characterized, and its cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32c111ad112c36492e4779343b54a85
https://pubmed.ncbi.nlm.nih.gov/34279540

Bystander immunotherapy as a strategy to control allergen-driven airway inflammation

Autor: Sébastien Fleury, Severine Navarro, Nicolas Glaichenhaus, A Kanda, David Dombrowicz, Anne Lazzari, Valérie Julia

Publikováno v: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2015, 8 (4), pp.841-851. ⟨10.1038/mi.2014.115⟩
Mucosal Immunology, 2015, 8 (4), pp.841-851. ⟨10.1038/mi.2014.115⟩

International audience; Allergic asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), lung infiltration of Th2 cells, and high levels of IgE. To date, allergen-specific immunotherapy (SIT) is the only treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d213c53e8f68090bfc11e41706a54b
https://doi.org/10.1038/mi.2014.115

Late Breaking Abstract - The 'one airway, one disease' concept at the light of Th2 inflammation

Autor: Charles-Hugo Marquette, Nicolas Pons, Virginie Magnone, Agnès Paquet, Julie Cazareth, Valérie Julia, Benoit Chevalier, Brice Marcet, Lisa Giovannini-Chami, Sylvie Leroy, Pascal Barbry, Céline Sanfiorenzo, Kevin Le Brigand

Publikováno v: Molecular Pathology and Functional Genomics.

Rationale: A pathophysiologic continuum has been described between nose and bronchus in allergic respiratory diseases, but no study has directly compared gene expression profiles of nasal and bronchial epithelium in a same individual. Aims and object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd909ecad06798893c16f1c9d1523ca4
https://doi.org/10.1183/1393003.congress-2017.pa4938