Phenotypic and Genomic Variability of Serial Peri-Lung Transplantation Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

Autor: Rucha Datar, Andreu Coello Pelegrin, Sylvain Orenga, Valérie Chalansonnet, Caroline Mirande, Jill Dombrecht, John D. Perry, Audrey Perry, Herman Goossens, Alex van Belkum

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

Cystic fibrosis (CF) represents one of the major genetic and chronic lung diseases affecting Caucasians of European descent. Patients with CF suffer from recurring infections that lead to further damage of the lungs. Pulmonary infection due to Pseudo

Externí odkaz: https://doaj.org/article/05d4a45ffcec4c0aad49bba6d068fd6d

Fluorogenic 7-azidocoumarin and 3/4-azidophthalimide derivatives as indicators of reductase activity in microorganisms

Autor: John D. Perry, John Lowe, Hannah E. Sykes, Thang V. Truong, Stephen P. Stanforth, Sylvain Orenga, Valérie Chalansonnet, Shaun N. Robinson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:2354-2357

A series of fluorogenic heterocyclic azides were prepared and assessed as reductase substrates across a selection of Gram-negative and Gram-positive microorganisms. The majority of these azides showed similar activity profiles to nitroreductase subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec10d305e44dd356a2d41507222df358
https://doi.org/10.1016/j.bmcl.2019.06.010

Phenotypic and genomic variability of serial peri-lung transplantation Pseudomonas aeruginosa isolates from cystic fibrosis patients

Autor: Caroline Mirande, Audrey Perry, Alex van Belkum, Sylvain Orenga, John D. Perry, Andreu Coello Pelegrin, Jill Dombrecht, Herman Goossens, Valérie Chalansonnet, Rucha Datar

Publikováno v: Frontiers in microbiology
Frontiers in Microbiology, Vol 12 (2021)
Frontiers in Microbiology

Cystic fibrosis (CF) represents one of the major genetic and chronic lung diseases affecting Caucasians of European descent. Patients with CF suffer from recurring infections that lead to further damage of the lungs. Pulmonary infection due to Pseudo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ccd995aa380cae8aa83aa0b6035e3e
https://hdl.handle.net/10067/1782650151162165141

Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activity

Autor: Sylvain Orenga, Valérie Chalansonnet, Claire Mercier, Christophe Gilbert

Publikováno v: BMC Microbiology, Vol 17, Iss 1, Pp 1-10 (2017)
BMC Microbiology
BMC Microbiology, BioMed Central, 2017, 17 (1), pp.126. ⟨10.1186/s12866-017-1033-3⟩
BMC Microbiology, 2017, 17 (1), pp.126. ⟨10.1186/s12866-017-1033-3⟩

International audience; BACKGROUND: Nitroreductases, NAD(P)H dependent flavoenzymes, are found in most of bacterial species. Even if Enterococcus faecalis strains seems to present such activity because of their sensitivity to nitrofurans, no enzyme h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e38eadc4d1f28de930fe6c17f5be20
http://link.springer.com/article/10.1186/s12866-017-1033-3

Characteristics of major Escherichia coli reductases involved in aerobic nitro and azo reduction

Autor: Sylvain Orenga, Valérie Chalansonnet, Claire Mercier, Christophe Gilbert

Publikováno v: Journal of Applied Microbiology
Journal of Applied Microbiology, 2013, 115 (4), pp.1012-1022. ⟨10.1111/jam.12294⟩
Journal of Applied Microbiology, Wiley, 2013, 115 (4), pp.1012-1022. ⟨10.1111/jam.12294⟩

Aims Escherichia coli is able to reduce azo compounds such as methyl red (MR) and nitro compounds such as 7-nitrocoumarin-3-carboxylic acid (7NCCA). The aim of this study was to clarify the specificity of the major E. coli reductases. Methods and Res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8e60ebf5c6b044cd7f9952f3f09083
https://hal.science/hal-01909021