Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Valérie, Brunner"'
1
Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [11C]-(+)-PHNO
Autor: Ludovic Leriche, Thomas B. Cooper, Anissa Abi-Dargham, Agnès Montagne, Valérie Brunner, Simon Joseph, Marlène Guiraud, Florence Gaudoux, Patrick Carberry, Mark Slifstein, Chaitanya R. Divgi, Raymond F. Suckow, Pierre Sokoloff, Ragy R. Girgis, Françoise Tonner, Shunichi Oya
Publikováno v: Psychopharmacology. 237:519-527
F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7f82ff674fc257a245221e943447376
https://doi.org/10.1007/s00213-019-05387-w
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2
Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [
Autor: Mark, Slifstein, Anissa, Abi-Dargham, Ragy R, Girgis, Raymond F, Suckow, Thomas B, Cooper, Chaitanya R, Divgi, Pierre, Sokoloff, Ludovic, Leriche, Patrick, Carberry, Shunichi, Oya, Simon K, Joseph, Marlène, Guiraud, Agnès, Montagne, Valérie, Brunner, Florence, Gaudoux, Françoise, Tonner
Publikováno v: Psychopharmacology. 237(2)
F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::daaba2ad04576f3a57ec70c3ddd92730
https://pubmed.ncbi.nlm.nih.gov/31773210
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3
Randomized, double-blind, placebo-controlled study of F17464, a preferential D(3) antagonist, in the treatment of acute exacerbation of schizophrenia
Autor: Laurence Barthe, Jeffrey A. Lieberman, Rajeev Chavda, Agnès Montagne, Françoise Tonner, Pierre Sokoloff, Carine Fabre, Marine Fagard, Florence Gaudoux, Valérie Brunner, Mélanie Groc, István Bitter, Cécile Delsol
Publikováno v: Neuropsychopharmacology
F17464, a highly potent preferential D3 antagonist, is a novel compound in development for schizophrenia treatment. This phase II, double-blind, randomized, placebo-controlled, parallel-group study in five European countries evaluated the efficacy an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fc002339efb06628fcda7f22972832
https://europepmc.org/articles/PMC6785149/
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4
Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats
Autor: Philippe Hermann, Louise Roques, Laurence Barthe, Laishun Chen, Isabelle Hude, Bernadette Maynadier, Valérie Brunner, Sébastien Séguier
Publikováno v: Drug Design, Development and Therapy
Valérie Brunner,1 Bernadette Maynadier,2 Laishun Chen,3 Louise Roques,2 Isabelle Hude,2 Sébastien Séguier,2 Laurence Barthe,1 Philippe Hermann11Pierre Fabre Médicament, Centre de R&D, Toulouse, 2Centre Experimental PreClinque, Campans, France; 3F
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8b3e8b0050d7349ce0ecb62f3c2613
http://europepmc.org/articles/PMC4484650
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5
Propranolol pharmacokinetics in infants treated for Infantile Hemangiomas requiring systemic therapy: Modeling and dosing regimen recommendations
Autor: Laurent Guibaud, Laurence Del Frari, Jean-Philippe Lacour, Valérie Brunner, Sébastien Barbarot, Alain Delarue, Jean-Jacques Voisard, Christine Léauté-Labrèze, Christine Chaumont
Publikováno v: Pharmacology Research & Perspectives
Propranolol has become the first choice therapy for complicated Infantile Hemangiomas (IH). The pharmacokinetics of propranolol were evaluated after repeated oral administration of a new pediatric solution of propranolol at 3 mg kg−1 day−1 given
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dd34951cabb6c0edb319da8d4b7ca3
https://pubmed.ncbi.nlm.nih.gov/29736244
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6
A pharmacogically guided phase I study of carboplatin in combination with methotrexate and vinblastine in advanced urothelial cancer
Autor: Mathilde Martinez, Valérie Brunner, Pierre Canal, Christine Chevreau, Etienne Chatelut, Georges Houin, Roland Bugat
Publikováno v: Cancer Chemotherapy and Pharmacology. 35:391-396
Carboplatin is an alternative for cisplatin in the treatment of urothelial cancers. A pharmacologically guided phase I study of carboplatin in combination with methotrexate (30 mg/m2) and vinblastine (4 mg/m2) was conducted in ten patients by increme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0963c0a6d0a7c2fd5b73355ee89ab5
https://doi.org/10.1007/s002800050252
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7
Prediction of carboplatin clearance from standard morphological and biological patient characteristics
Autor: Henri Roché, Christine Chevreau, Valérie Brunner, A. Pujol, Roland Bugat, Etienne Chatelut, Andrée Boneu, Pierre Canal, Georges Houin
Publikováno v: Journal of the National Cancer Institute. 87(8)
BACKGROUND Hematologic toxicity of an antineoplastic drug, carboplatin, is largely dependent on its pharmacokinetics. Its therapeutic efficacy may be related to plasma drug exposure. Dosage adjustment based on isotopic determination of glomerular fil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc85ad7a22b99a20e1b80c32efbcbb9
https://pubmed.ncbi.nlm.nih.gov/9017009
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9
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