Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Valérie, Audinot"'
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Melanin-concentrating hormone (MCH) receptors (provisional nomenclature as recommended by NC-IUPHAR [32]) are activated by an endogenous nonadecameric cyclic peptide identical in humans and rats (DFDMLRCMLGRVYRPCWQV; mammalian MCH) generated from a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcd17e93442384505ad7ab08f77e9d6d
https://doi.org/10.2218/gtopdb/f37/2023.1
https://doi.org/10.2218/gtopdb/f37/2023.1
Autor:
Jean-Philippe Stephan, Philippe Delagrange, Valérie Audinot, Preety Shabajee-Alibay, Saïd Yous, Benoît Malpaux, Jérôme Leprince, Anne Bonnaud, Jean A. Boutin, Céline Legros
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 380:76-89
In mammals, MT1 and MT2 melatonin receptors are high affinity G protein-coupled receptors and are thought to be involved in the integration of the melatonin signaling throughout the brain and periphery. In the present study, we describe a new melaton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b8b8816f2585d72be623069da9fd63
https://doi.org/10.1124/jpet.121.000785
https://doi.org/10.1124/jpet.121.000785
Autor:
Jean-Marie Delbos, Esther Steidl, Tuulia Huhtala, Aurore Sors, Jean-Michel Arrang, Bruno Buisson, Patrick Casara, Outi Kontkanen, Lionel Bert, Valérie Audinot, Pierre Lestage, Olivier Nosjean, Anne-Marie Chollet, Fany Panayi, Dominique Favale
Publikováno v:
European Journal of Pharmacology. 803:11-23
Histaminergic H3 inverse agonists, by stimulating central histamine release, represent attractive drug candidates to treat cognitive disorders. The present studies aimed to describe the mechanistic profile of S 38093 a novel H3 receptors inverse agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e956afc9c4cbf151304775e3b54917d
https://doi.org/10.1016/j.ejphar.2017.03.013
https://doi.org/10.1016/j.ejphar.2017.03.013
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Melanin-concentrating hormone (MCH) receptors (provisional nomenclature as recommended by NC-IUPHAR [31]) are activated by an endogenous nonadecameric cyclic peptide identical in humans and rats (DFDMLRCMLGRVYRPCWQV; mammalian MCH) generated from a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9761cd8caca5d77a8dc7acf90c2fb286
https://doi.org/10.2218/gtopdb/f37/2019.4
https://doi.org/10.2218/gtopdb/f37/2019.4
Autor:
Daniel-Henri Caignard, Alain Ktorza, Amaury Farce, Valérie Audinot-Bouchez, Jean-Albert Boutin, Michel Lonchampt, Nathalie Hennuyer, Catherine Dacquet, Nicolas Lebegue, Morgan Le Naour, Pascal Berthelot, Bart Staels, Veronique Leclerc
Publikováno v:
ChemMedChem. 7:2179-2193
Compounds that simultaneously activate peroxisome proliferator-activated receptor (PPAR) subtypes α and γ have the potential to effectively treat dyslipidemia and type 2 diabetes (T2D) in a single pharmaceutically active molecule. The frequently ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e50b70924072f6e33837068ee35982
https://doi.org/10.1002/cmdc.201200316
https://doi.org/10.1002/cmdc.201200316
Autor:
Pierre Renard, Philippe Chavatte, Christophe Mesangeau, Valérie Audinot, Basile Pérès, Philippe Delagrange, Saïd Yous, Daniel H. Caignard, Jean A. Boutin, Pascal Berthelot, Sophie Coumailleau, Caroline Bennejean, Descamps-Francois Carole
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:3426-3436
Novel heterodimer analogues of melatonin were synthesized, when agomelatine (1) and various aryl units are linked via a linear alkyl chain through the methoxy group. The compounds were tested for their actions at melatonin receptors. Several of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b748bf30437900a1a7b6edb83b2e9fe8
https://doi.org/10.1016/j.bmc.2010.04.008
https://doi.org/10.1016/j.bmc.2010.04.008
Autor:
Olivier Nosjean, Odile Della Zuana, Valérie Audinot, Nelly Fabry, Jean-Michel Henlin, Christine Ouvry, Jean A. Boutin, Jean-Luc Fauchère
Publikováno v:
Peptides. 30:1997-2007
Structure–activity relationships studies have established the minimal sequence of melanin-concentrating hormone (MCH) that retains full agonist potency at the MCH 1 , to be the dodecapeptide MCH(6-17). The α-amino function is not required for acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b24b31de4c45a224495a28e8ca13e7
https://doi.org/10.1016/j.peptides.2009.07.007
https://doi.org/10.1016/j.peptides.2009.07.007
Autor:
Daniel Lesieur, Pierre Renard, Philippe Delagrange, Angéline Chanu, Sophie Coumailleau, Caroline Bennejean, Pascal Berthelot, Jean A. Boutin, Christophe Bochu, Saïd Yous, Sophie Durieux, Daniel H. Caignard, Valérie Audinot
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:2963-2974
Following our studies of the melatoninergic receptors, we have developed new tetrahydronaphthalenic derivatives of melatonin that have been tested as selective melatonin receptors ligands. Regarding the role of the phenyl substituent to obtain select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1a362deb96013ac9c228b3ce80fd6b
https://doi.org/10.1016/j.bmc.2009.03.023
https://doi.org/10.1016/j.bmc.2009.03.023
Autor:
Catherine Dacquet, Valérie Audinot-Bouchez, Alain Ktorza, Jean A. Boutin, René Grée, Melanie Liutkus, Daniel-Henri Caignard
Publikováno v:
Letters in Drug Design & Discovery. 5:503-511
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0322d9aa92e446bdb8745e151b518483
https://doi.org/10.2174/157018008786898572
https://doi.org/10.2174/157018008786898572
Autor:
Daniel Lesieur, Basile Peres, Daniel Henri Caignard, Valérie Audinot, Caroline Bennejean, Jean A. Boutin, Philippe Delagrange, Pierre Renard, Saïd Yous, Mohamed Ettaoussi, Pascal Berthelot, Sophie Poissonnier-Durieux
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:8339-8348
A series of naphthalenic analogues of melatonin were prepared and evaluated as melatonin receptor MT(2) selective ligands. Activity and MT(2) selectivity can be modulated with suitable variations of the C-3 phenyl and the acyl group on the C-1 side c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530373a7fb1652ecc2962878e1de4771
https://doi.org/10.1016/j.bmc.2008.08.052
https://doi.org/10.1016/j.bmc.2008.08.052