Výsledky vyhledávání - "Valéria Tékus"

Akademický článek

Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model

Autor: Ádám István Horváth, Kata Bölcskei, Nikolett Szentes, Éva Borbély, Valéria Tékus, Bálint Botz, Kitti Rusznák, Anett Futácsi, Boldizsár Czéh, Péter Mátyus, Zsuzsanna Helyes

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

IntroductionMonoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxa

Externí odkaz: https://doaj.org/article/7cfe2dd453ac46c1bfdceb5f12491f4b

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Akademický článek

Antibody-mediated autoimmunity in symptom-based disorders: position statement and proceedings from an international workshop

Publikováno v: PAIN Reports, Vol 9, Iss 4, p e1167 (2024)

Abstract. A 2-day closed workshop was held in Liverpool, United Kingdom, to discuss the results of research concerning symptom-based disorders (SBDs) caused by autoantibodies, share technical knowledge, and consider future plans. Twenty-two speakers

Externí odkaz: https://doaj.org/article/d2890ffbc47c48bda34575e7e82fdf06

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Akademický článek

Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4)

Autor: Márk Kozsurek, Kornél Király, Klára Gyimesi, Erika Lukácsi, Csaba Fekete, Balázs Gereben, Petra Mohácsik, Zsuzsanna Helyes, Kata Bölcskei, Valéria Tékus, Károly Pap, Edina Szűcs, Sándor Benyhe, Tímea Imre, Pál Szabó, Andrea Gajtkó, Krisztina Holló, Zita Puskár

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 2, p 918 (2023)

Cocaine- and amphetamine-regulated transcript (CART) peptides are involved in several physiological and pathological processes, but their mechanism of action is unrevealed due to the lack of identified receptor(s). We provided evidence for the antihy

Externí odkaz: https://doaj.org/article/b56c7fa4f70d495393cbbd75d0542fef

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Akademický článek

Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats

Autor: Valéria Tékus, Ádám István Horváth, Kata Csekő, Krisztina Szabadfi, Andrea Kovács-Valasek, Bese Dányádi, László Deres, Róbert Halmosi, Éva Sághy, Zoltán V. Varga, Ernest Adeghate, Tamás Kőszegi, Péter Mátyus, Róbert Gábriel, Péter Ferdinandy, Erika Pintér, Zsuzsanna Helyes

Publikováno v: Biomedicine & Pharmacotherapy, Vol 134, Iss , Pp 111105- (2021)

Diabetes mellitus is a common metabolic disease leading to hyperglycemia due to insufficient pancreatic insulin production or effect. Amine oxidase copper containing 3 (AOC3) is an enzyme that belongs to the semicarbazide-sensitive amine oxidase fami

Externí odkaz: https://doaj.org/article/58d82bcd6dbd4df3904db0c3d4c3209c

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Akademický článek

Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain

Autor: Kornél Király, Márk Kozsurek, Erika Lukácsi, Benjamin Barta, Alán Alpár, Tamás Balázsa, Csaba Fekete, Judit Szabon, Zsuzsanna Helyes, Kata Bölcskei, Valéria Tékus, Zsuzsanna E. Tóth, Károly Pap, Gábor Gerber, Zita Puskár

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)

Abstract Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various pain states, and remain difficult to treat. We have shown previously that spinal application of dipeptidyl peptidase 4 (DPP4) inhibitors induce

Externí odkaz: https://doaj.org/article/24d74c8afb4446d58b71a3a0eb302c9f

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Akademický článek

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

Autor: Ádám István Horváth, Nikolett Szentes, Valéria Tékus, Maja Payrits, Éva Szőke, Emőke Oláh, András Garami, Eszter Fliszár-Nyúl, Miklós Poór, Cecília Sár, Tamás Kálai, Szilárd Pál, Krisztina Percze, Éva Nagyné Scholz, Tamás Mészáros, Blanka Tóth, Péter Mátyus, Zsuzsanna Helyes

Publikováno v: Biomedicines, Vol 9, Iss 7, p 749 (2021)

SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRP

Externí odkaz: https://doaj.org/article/b78a30cd91f84207aab5435c4944b4c9

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Akademický článek

Dimethyl Trisulfide Diminishes Traumatic Neuropathic Pain Acting on TRPA1 Receptors in Mice

Autor: Ágnes Dombi, Csenge Sánta, István Z. Bátai, Viktória Kormos, Angéla Kecskés, Valéria Tékus, Krisztina Pohóczky, Kata Bölcskei, Erika Pintér, Gábor Pozsgai

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7, p 3363 (2021)

Pharmacotherapy of neuropathic pain is still challenging. Our earlier work indicated an analgesic effect of dimethyl trisulfide (DMTS), which was mediated by somatostatin released from nociceptor nerve endings acting on SST4 receptors. Somatostatin r

Externí odkaz: https://doaj.org/article/f4473227390a4c9c9dbf60dae340a096

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The Hypothermic Effect of Hydrogen Sulfide Is Mediated by the Transient Receptor Potential Ankyrin-1 Channel in Mice

Autor: Erika Pintér, Patrik Keringer, Balázs Gaszner, Eszter Pakai, Valéria Tékus, András Garami, Hannah Wilson, Viktória Kormos, Kata Fekete, Leonardo Kelava, Emoke Olah, Julie Keeble, Margit Solymár, Zoltan Rumbus, Matthew Whiteman

Publikováno v: Pharmaceuticals, Vol 14, Iss 992, p 992 (2021)
Pharmaceuticals
Volume 14
Issue 10

Hydrogen sulfide (H2S) has been shown in previous studies to cause hypothermia and hypometabolism in mice, and its thermoregulatory effects were subsequently investigated. However, the molecular target through which H2S triggers its effects on deep b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9376c631d680e3aa3f13485516041ce
https://www.mdpi.com/1424-8247/14/10/992

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Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

Autor: Emőke Oláh, Valéria Tékus, Ádám Horváth, Éva Nagyné Scholz, Tamás Mészáros, Cecília P. Sár, Nikolett Szentes, Tamás Kálai, Zsuzsanna Helyes, Blanka Tóth, András Garami, Péter Mátyus, Miklós Poór, Krisztina Percze, Maja Payrits, Szilárd Pál, Éva Szőke, Eszter Fliszár-Nyúl

Publikováno v: Biomedicines
Volume 9
Issue 7
Biomedicines, Vol 9, Iss 749, p 749 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506872a8487a17207dfd6f50747d62c3

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Exploratory and locomotor activity, learning and memory functions in somatostatin receptor subtype 4 gene-deficient mice in relation to aging and sex

Autor: Valéria Tékus, Nikolett Szentes, Zsuzsanna Helyes, Violetta Mohos, Éva Borbély

Publikováno v: GeroScience

The inhibitory neuropeptide somatostatin regulates several functions in the nervous system including memory. Its concentrations decrease by age leading to functional alterations, but there are little known about the receptorial mechanism. We discover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b2c4145f02709886ba4c25b459c030
http://europepmc.org/articles/PMC6885027

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