Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Vajihe Akbari"'
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Immunotoxins are widely applied for cancer therapy. However, bacterial expression of immunotoxins usually leads to the formation of insoluble and non-functional recombinant proteins. This study was aimed to improve soluble expression of a no
Externí odkaz:
https://doaj.org/article/b028f0614c4c454b8ac5787f55ed7b01
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Using natural killer (NK) cells to treat hematopoietic and solid tumors has great promise. Despite their availability from peripheral blood and cord blood, stem cell-derived NK cells provide an “off-the-shelf” solution. Method
Externí odkaz:
https://doaj.org/article/f700e815795149b69e57d2aca57b835c
Autor:
Mehran Beyki Dehabadi, Vajihe Akbari
Publikováno v:
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 32, Iss 3, Pp 7596-7612 (2024)
Introduction: Using the immune system responses opens new horizons for cancer treatment. Immune checkpoints are receptors on the surface of cells that prevent the immune response against self-antigens. Cancer cells overexpress these receptors to avoi
Externí odkaz:
https://doaj.org/article/4d7f28ea22a04bca8ca0a3e45889c045
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35509- (2024)
Adoptive immunotherapies that use functional NK cells depend on the availability of sufficient numbers of these cells. We expanded umbilical cord blood (UCB)-CD34+ HSCs for 2 weeks and then differentiated them into NK cells and compared their functio
Externí odkaz:
https://doaj.org/article/f1b4f5ed232444aca530ef8bd54ca608
Autor:
Maryam Beheshti Isfahani, Karim Mahnam, Hooria Seyedhosseini-Ghaheh, Hamid Mir Mohammad Sadeghi, Hossein Khanahmad, Vajihe Akbari, Jaleh Varshosaz
Publikováno v:
Research in Pharmaceutical Sciences, Vol 18, Iss 6, Pp 626-637 (2023)
Background and purpose: Human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 25% of breast cancer patients; therefore, its inhibition is a therapeutic target in cancer treatment. Experimental approach: In this study, two
Externí odkaz:
https://doaj.org/article/4a57980357f748c8aca70a95bfb19eec
Publikováno v:
Research in Pharmaceutical Sciences, Vol 17, Iss 1, Pp 43-52 (2022)
Background and purpose: One of the most effective methods for the development of dendritic cell (DC)-based cancer immunotherapy is ex vivo pulsing of DCs with tumor cell lysates (TCLs). However, antitumor immune responses of DCs are significantly inf
Externí odkaz:
https://doaj.org/article/967ef07eb1bb4a569d4a036d15ba47c1
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 58 (2022)
Abstract Interferon-β-1a (INF-β-1a) has gained significant attention due to its emerging applications in the treatment of different human diseases. Therefore, many researchers have attempted to produce it in large quantities and also in a biologica
Externí odkaz:
https://doaj.org/article/06d4894154f24f1fa375aa2d1b00dd02
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 1, Pp 97-106 (2020)
Background and purpose: Bone regeneration can be accelerated by localized delivery of statins. Here, we aimed to evaluate the effect of two thermosensitive hydrogels containing rosuvastatin (RSV) on proliferation and differentiation of human osteobla
Externí odkaz:
https://doaj.org/article/abe328b69e674a6db516d547195d81f0
Autor:
Hossein Mohammadian, Karim Mahnam, Hamid Mirmohammad Sadeghi, Mohamad Reza Ganjalikhany, Vajihe Akbari
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 2, Pp 164-173 (2020)
Background and purpose: Tobacco etch virus (TEV) protease is a protease with high sequence specificity which is useful for the cleavage of fusion proteins. A major limitation of this enzyme is its relatively poor solubility. This study aimed to inves
Externí odkaz:
https://doaj.org/article/6fde3842b55e4fa1a737b17517aa6aef
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 3, Pp 218-225 (2020)
Background and purpose: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine with a wide range of therapeutic applications although expression of GM-CSF in Escherichia coli (E. coli) usually leads to formation of insoluble aggregat
Externí odkaz:
https://doaj.org/article/a32cb1ab45c5431dbaf778f906bb215a