Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vaishnavi Srinivasan Iyer"'
Autor:
Yunbing Shen, Long Jiang, Vaishnavi Srinivasan Iyer, Bruno Raposo, Anatoly Dubnovitsky, Sanjaykumar V. Boddul, Zsolt Kasza, Fredrik Wermeling
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5360-5370 (2021)
CRISPR/Cas9 can be used as an experimental tool to inactivate genes in cells. However, a CRISPR-targeted cell population will not show a uniform genotype of the targeted gene. Instead, a mix of genotypes is generated - from wild type to different for
Externí odkaz:
https://doaj.org/article/7ef9e66cdc654f80b5bdd9d389d86c63
Autor:
Vaishnavi Srinivasan Iyer, Long Jiang, Yunbing Shen, Sanjaykumar V. Boddul, Sudeepta Kumar Panda, Zsolt Kasza, Bernhard Schmierer, Fredrik Wermeling
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2237-2246 (2020)
Over the last decade Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) has been developed into a potent molecular biology tool used to rapidly modify genes or their expression in a multitude of ways. In parallel, CRISPR-based screeni
Externí odkaz:
https://doaj.org/article/4522dbaaed7845b788333524d85a502d
Autor:
Sanjaykumar V. Boddul, Ravi Kumar Sharma, Anatoly Dubnovitsky, Bruno Raposo, Christina Gerstner, Yunbing Shen, Vaishnavi Srinivasan Iyer, Zsolt Kasza, William W. Kwok, Aaron R. Winkler, Lars Klareskog, Vivianne Malmström, Maria Bettini, Fredrik Wermeling
Publikováno v:
Journal of Translational Autoimmunity, Vol 4, Iss , Pp 100087- (2021)
Recent advances in single-cell sequencing technologies enable the generation of large-scale data sets of paired TCR sequences from patients with autoimmune disease. Methods to validate and characterize patient-derived TCR data are needed, as well as
Externí odkaz:
https://doaj.org/article/2b65dc3e4d654d289c3343c4f2d8dba0
Autor:
Fredrik Wermeling, David P. Lane, Saikiran Sedimbi, Zsolt Kasza, Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Yunbing Shen, Katrine Ingelshed, Long Jiang
Inactivating p53 mutations are the most abundant genetic alterations found in cancer. Here we show that CRISPR/Cas9-induced double-stranded DNA breaks enrich for cells deficient in p53 and in genes of a core CRISPR–p53 tumor suppressor interactome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63d65978637a6ba00b4d2840f6b1d1f
https://doi.org/10.1158/0008-5472.c.6513898.v1
https://doi.org/10.1158/0008-5472.c.6513898.v1
Autor:
Fredrik Wermeling, David P. Lane, Saikiran Sedimbi, Zsolt Kasza, Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Yunbing Shen, Katrine Ingelshed, Long Jiang
Supplementary Figure from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646b18f81805a689211d1d480e95d49a
https://doi.org/10.1158/0008-5472.22431412.v1
https://doi.org/10.1158/0008-5472.22431412.v1
Autor:
Fredrik Wermeling, David P. Lane, Saikiran Sedimbi, Zsolt Kasza, Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Yunbing Shen, Katrine Ingelshed, Long Jiang
Supplementary Table from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574fb2ee3fdc5a8d80202b8e8efe9285
https://doi.org/10.1158/0008-5472.22431409
https://doi.org/10.1158/0008-5472.22431409
Autor:
Fredrik Wermeling, David P. Lane, Saikiran Sedimbi, Zsolt Kasza, Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Yunbing Shen, Katrine Ingelshed, Long Jiang
Supplementary Data from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2675c7679a4a767b8524451674b21104
https://doi.org/10.1158/0008-5472.22431415
https://doi.org/10.1158/0008-5472.22431415
Autor:
Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Anna-Karin Johnsson, Bruno Raposo, Ravi K. Sharma, Yunbing Shen, Zsolt Kasza, Kah Wai Lim, Karine Chemin, Gunnar Nilsson, Vivianne Malmström, Anh Tuân Phan, Fredrik Wermeling
Publikováno v:
Journal of autoimmunity. 131
Dysregulated T-cell activation is a hallmark of several autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The lymphocyte cytosolic protein 2 (LCP2), also known as SLP-76, is essential for the development and activatio
Autor:
Long, Jiang, Katrine, Ingelshed, Yunbing, Shen, Sanjaykumar V, Boddul, Vaishnavi Srinivasan, Iyer, Zsolt, Kasza, Saikiran, Sedimbi, David P, Lane, Fredrik, Wermeling
Publikováno v:
Cancer research. 82(1)
Inactivating
Autor:
Vaishnavi Srinivasan Iyer, Saikiran K. Sedimbi, Zsolt Kasza, Fredrik Wermeling, Yunbing Shen, Long Jiang, Katrine Ingelshed, David P. Lane, Sanjay V. Boddul
CRISPR/Cas9 can be used to inactivate or modify genes by inducing double-stranded DNA breaks1–3. As a protective cellular response, DNA breaks result in p53-mediated cell cycle arrest and activation of cell death programs4,5. Inactivatingp53mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddfd8fa24324b0330cea9e02622c1638
https://doi.org/10.1101/2021.03.10.434760
https://doi.org/10.1101/2021.03.10.434760