Zobrazeno 1 - 10
of 344
pro vyhledávání: '"Vaishali Sanchorawala"'
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-5 (2023)
Abstract Background Hyperammonemic encephalopathy (HE) is a rare and life-threatening complication of multiple myeloma, with underlying mechanisms that are not fully understood. In contrast to previously reported cases, most of which have been associ
Externí odkaz:
https://doaj.org/article/f2294c4ad9ab4245939296e952807df1
Autor:
Cameron S. Fraser, Johan K. E. Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N. Hata, Jeffrey W. Miller, Gary A. Bradshaw, Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek, Kristopher A. Sarosiek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al. show that BH3 mimetics, which inhibit pro-survival proteins BCL-2 or MCL-
Externí odkaz:
https://doaj.org/article/af565676a38f48089f10fb446aad1c14
Autor:
Andrea Havasi, Cihan Heybeli, Nelson Leung, Avital Angel-Korman, Vaishali Sanchorawala, Oliver Cohen, Ashutosh Wechalekar, Frank Bridoux, Insara Jaffer, Victoria Gutgarts, Hani Hassoun, Maya Levinson, Cara Rosenbaum, Paolo Milani, Giovanni Palladini, Giampaolo Merlini, Ute Hegenbart, Stefan Schönland, Kaya Veelken, Alexander Pogrebinsky, Gheorghe Doros, Heather Landau
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 8, Pp 1-8 (2022)
Abstract Effective systemic therapies suppress toxic light chain production leading to an increased proportion of patients with light chain (AL) amyloidosis who survive longer albeit with end-stage renal disease. There is a critical need to identify
Externí odkaz:
https://doaj.org/article/8310aa42eeb54a7f8e5412643a28329a
Autor:
Katherine E. Rowan, Adebanke L. Adebayo, Mackenzie N. Boedicker, Vaishali Sanchorawala, Deborah D. Boedicker
Publikováno v:
MedEdPublish, Vol 13 (2023)
Background: Amyloidosis is a complex multi-systemic disease. Lack of knowledge about amyloidosis and subsequent mis- or under-diagnosis are major obstacles to treatment, which result in life-threatening organ damage, morbidity, and mortality. Hence,
Externí odkaz:
https://doaj.org/article/2b42371cef2c4e8c8971f28a632e1457
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 7, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/fcb757116ec340c9b3397ca4a0787a99
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMonoclonal antibody light chain proteins secreted by clonal plasma cells cause tissue damage due to amyloid deposition and other mechanisms. The unique protein sequence associated with each case contributes to the diversity of clinical fe
Externí odkaz:
https://doaj.org/article/7a9ef7146de34093b76a7b26de66d1b4
Autor:
Hamza Hassan, Vaishali Sanchorawala
Publikováno v:
Hemato, Vol 3, Iss 1, Pp 38-46 (2022)
The survivorship needs of patients with light-chain (AL) amyloidosis are complex, as is the diagnosis and treatment itself. Early diagnosis is critical in improving patient outcomes; however, given the nonspecific nature of the symptoms, most patient
Externí odkaz:
https://doaj.org/article/014de3d195cb4bd897fcb7fd8b898d54
Autor:
Joshua N. Gustine, Raphael E. Szalat, Andrew Staron, Tracy Joshi, Lisa Mendelson, J. Mark Sloan, Vaishali Sanchorawala
Publikováno v:
Haematologica, Vol 108, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/e326eddab0914ffc9ff75e4ddccc7bd0
Autor:
Andrew Staron, Luke Zheng, Gheorghe Doros, Lawreen H. Connors, Lisa M. Mendelson, Tracy Joshi, Vaishali Sanchorawala
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 8, Pp 1-10 (2021)
Abstract The recent decades have ushered in considerable advancements in the diagnosis and treatment of systemic light chain (AL) amyloidosis. As disease outcomes improve, AL amyloidosis-unrelated factors may impact mortality. In this study, we evalu
Externí odkaz:
https://doaj.org/article/daa8f21e99424a81873f249c512890d8
Autor:
Shayna Sarosiek, Cindy Varga, Allison Jacob, Maria Teresa Fulciniti, Nikhil Munshi, Vaishali Sanchorawala
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 6, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/97ba9c4152d8477fbd7531c41d528576