Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Vaikar Navakanth Rao"'
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1478 (2023)
Morphine (MOR) is a commonly prescribed drug for the treatment of moderate to severe diabetic neuropathic pain (DNP). However, long-term MOR treatment is limited by morphine analgesic tolerance (MAT). The activation of microglial cells and the releas
Externí odkaz:
https://doaj.org/article/b8edc2d6761a4aedbfce7212ec21a820
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1438 (2021)
Neuropathic pain (NP), is a chronic pain resulting from nerve injury, with limited treatment options. Teneligliptin (TEN) is a dipeptidyl peptidase-4 inhibitor (DPP-4i) approved to treat type 2 diabetes. DPP-4is prevent the degradation of the increti
Externí odkaz:
https://doaj.org/article/fe09717a530f4a2f8ebd17348383307c
Autor:
Yaswanth Kuthati, Prabhakar Busa, Srikrishna Tummala, Vaikar Navakanth Rao, Venkata Naga Goutham Davuluri, Yen-Peng Ho, Chih-Shung Wong
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 195 (2021)
Oxidative stress resulting from reactive oxygen species (ROS) is known to play a key role in numerous neurological disorders, including neuropathic pain. Morphine is one of the commonly used opioids for pain management. However, long-term administrat
Externí odkaz:
https://doaj.org/article/e3f7e2a4de8e41bd8ded92641c39e539
Autor:
Yaswanth Kuthati, Chih Shung Wong, Goutham Davuluri Venkata Naga, Vaikar Navakanth Rao, Prabhakar Busa, Srikrishna Tummala
Publikováno v:
Molecular Pharmaceutics. 17:1015-1027
Neuropathic pain, resulting from the dysfunction of the peripheral and central nervous system, occurs in a variety of pathological conditions including trauma, diabetes, cancer, HIV, surgery, multiple sclerosis, ischemic attack, alcoholism, spinal co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232b4f0ecb62107c29b238696c80a3b8
https://doi.org/10.1021/acs.molpharmaceut.9b01027
https://doi.org/10.1021/acs.molpharmaceut.9b01027
Autor:
Vaikar Navakanth Rao, Kuo-Chu Lai, Chin-Hung Liu, Shung-Haur Yang, Jeou-Yuan Chang, Tsann-Long Su, Te-Chang Lee
Publikováno v:
Cancer Research. 82:B010-B010
Background: Colorectal cancer (CRC) is the second-leading death of all cancers in the world. Metastasis is the basis for cause of death in patients with CRC. Currently, combination of anti-VEGF therapy and DNA damaging agents, such as Bevacizumab + F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1316e0800753d569c6f6f8c74d790d7b
https://doi.org/10.1158/1538-7445.crc22-b010
https://doi.org/10.1158/1538-7445.crc22-b010
Publikováno v:
Cancer Research. 82:1407-1407
Purpose: We have synthesized a bifunctional hybrid molecule BO-2762, which is able to induce DNA damage and inhibit angiogenesis simultaneously [1] as similar to first-line chemotherapy combination (FOLFOX + Bevacizumab). Recently, colorectal cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::393ed9b52a34a8bfb9865de0b8751999
https://doi.org/10.1158/1538-7445.am2022-1407
https://doi.org/10.1158/1538-7445.am2022-1407
Autor:
Chih Shung Wong, Venkata Naga Goutham Davuluri, Vaikar Navakanth Rao, Yaswanth Kuthati, Yen-Peng Ho, Srikrishna Tummala, Prabhakar Busa
Publikováno v:
Antioxidants
Volume 10
Issue 2
Antioxidants, Vol 10, Iss 195, p 195 (2021)
Volume 10
Issue 2
Antioxidants, Vol 10, Iss 195, p 195 (2021)
Oxidative stress resulting from reactive oxygen species (ROS) is known to play a key role in numerous neurological disorders, including neuropathic pain. Morphine is one of the commonly used opioids for pain management. However, long-term administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aade450ed533567c1fa339ca956910c2
Publikováno v:
Cancer Research. 81:2648-2648
Purpose: We have synthesized a series of bifunctional molecules, which are able to induce DNA interstrand crosslinks and inhibit angiogenesis as potent anticancer agents [1] and leads to develop new hybrids molecules. To analyze one of the novel bifu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86c427599b77eabf32d352d34f6ab45f
https://doi.org/10.1158/1538-7445.am2021-2648
https://doi.org/10.1158/1538-7445.am2021-2648
Autor:
Vaikar Navakanth Rao, Anilkumar S. Patel, Yi-Wen Lin, Tsann-Long Su, Anamik Shah, Te-Chang Lee, Vicky Jain, Kuo-Chu Lai
Publikováno v:
European Journal of Medicinal Chemistry. 202:112516
A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates and 12,13-bis(hydroxymethyl)-9,14-dihydro-dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives were synthesized for antiprolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755ed09086ac7a031c8e6757886d680f
https://doi.org/10.1016/j.ejmech.2020.112516
https://doi.org/10.1016/j.ejmech.2020.112516