Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Vaibhav, Sahai"'
Autor:
Rishi Das, MD, MPH, Madeline R. Abbott, MS, Scott W. Hadley, PhD, Vaibhav Sahai, MBBS, MS, Filip Bednar, MD, PhD, Joseph R. Evans, MD, PhD, Matthew J. Schipper, PhD, Theodore S. Lawrence, MD, Kyle C. Cuneo, MD
Publikováno v:
Advances in Radiation Oncology, Vol 8, Iss 6, Pp 101266- (2023)
Purpose: Patients with pancreatic cancer undergoing chemoradiation therapy may experience acute and chronic side effects. We conducted an exploratory analysis of patients with locally advanced pancreatic cancer (LAPC) undergoing definitive chemoradia
Externí odkaz:
https://doaj.org/article/d703420b0afe4e16b9c4ce9ad37a7f41
Autor:
Thomas Enzler, Jiaqi Shi, Jake McGue, Brian D. Griffith, Lei Sun, Vaibhav Sahai, Hari Nathan, Timothy L. Frankel
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2953 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of 12.5%. PDAC predominantly arises from non-cystic pancreatic intraepithelial neoplasia (PanIN) and cystic intraductal papillary mucinous neoplasm (IPMN). W
Externí odkaz:
https://doaj.org/article/de54b933bbec4751846029c156df7147
Autor:
Chandan Kumar-Sinha, Pankaj Vats, Nguyen Tran, Dan R. Robinson, Valerie Gunchick, Yi-Mi Wu, Xuhong Cao, Yu Ning, Rui Wang, Erica Rabban, Janice Bell, Sunita Shankar, Rahul Mannan, Yuping Zhang, Mark M. Zalupski, Arul M. Chinnaiyan, Vaibhav Sahai
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 42, Iss , Pp 100910- (2023)
Background: Biliary tract cancers (BTCs) including intrahepatic, perihilar, and distal cholangiocarcinoma as well as gallbladder cancer, are rare but aggressive malignancies with few effective standard of care therapies. Methods: We implemented integ
Externí odkaz:
https://doaj.org/article/267f07005d4148529c8e940f763e1135
Publikováno v:
TH Open, Vol 06, Iss 03, Pp e221-e229 (2022)
Background Patients with pancreatic cancer are at high risk of developing venous thromboembolism (VTE). It is unknown if aspirin reduces the risk of VTE in this setting. Objectives We sought to determine whether there is an association between aspiri
Externí odkaz:
https://doaj.org/article/bba48acecc4b40dd9abe0af95f0394b1
Autor:
Arathi Mohan, Kent A. Griffith, Fulei Wuchu, David B. Zhen, Chandan Kumar-Sinha, Oxana Crysler, David Hsiehchen, Thomas Enzler, Dominique Dippman, Valerie Gunchick, Abhinav Achreja, Olamide Animasahun, Srinadh Choppara, Minal Nenwani, Arul M. Chinnaiyan, Deepak Nagrath, Mark M. Zalupski, Vaibhav Sahai
Publikováno v:
Clinical Cancer Research. :OF1-OF7
Purpose: Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC). Patients and Methods: Cel
Autor:
Eileen S. Carpenter, Ahmed M. Elhossiny, Padma Kadiyala, Jay Li, Jake McGue, Brian D. Griffith, Yaqing Zhang, Jacob Edwards, Sarah Nelson, Fatima Lima, Katelyn L. Donahue, Wenting Du, Allison C. Bischoff, Danyah Alomari, Hannah R. Watkoske, Michael Mattea, Stephanie The, Carlos E. Espinoza, Meredith Barrett, Christopher J. Sonnenday, Nicholas Olden, Chin-Tung Chen, Nicole Peterson, Valerie Gunchick, Vaibhav Sahai, Arvind Rao, Filip Bednar, Jiaqi Shi, Timothy L. Frankel, Marina Pasca di Magliano
Publikováno v:
Cancer Discovery. :OF1-OF22
The adult healthy human pancreas has been poorly studied given the lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors, thus avoiding any warm
Autor:
Zishuo Ian Hu, Johanna C. Bendell, Andrea Bullock, Noelle K. LoConte, Hassan Hatoum, Paul Ritch, Hugo Hool, Joseph W. Leach, James Sanchez, Davendra P. S. Sohal, John Strickler, Ravindranath Patel, Andrea Wang‐Gillam, Irfan Firdaus, Kenneth H. Yu, Ann M. Kapoun, Eric Holmgren, Lei Zhou, Jakob Dupont, Vincent Picozzi, Vaibhav Sahai, Eileen M. O'Reilly
Publikováno v:
Cancer Medicine, Vol 8, Iss 11, Pp 5148-5157 (2019)
Abstract Purpose Notch signaling dysregulation is implicated in the development of pancreatic adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that inhibits Notch2/3 receptors. Patients and Methods Aphase 2, randomized, placebo‐cont
Externí odkaz:
https://doaj.org/article/65d331d0de7c4b2799fe21f23c85e265
Autor:
Brittany Rupp, Sarah Owen, Harrison Ball, Kaylee Judith Smith, Valerie Gunchick, Evan T. Keller, Vaibhav Sahai, Sunitha Nagrath
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7852 (2022)
As pancreatic cancer is the third deadliest cancer in the U.S., the ability to study genetic alterations is necessary to provide further insight into potentially targetable regions for cancer treatment. Circulating tumor cells (CTCs) represent an esp
Externí odkaz:
https://doaj.org/article/d36747c4a4474359a5a1b0a2ce51c5d9
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 146 (2022)
Pancreatic ductal adenocarcinoma is typically diagnosed at late stages and has one of the lowest five-year survival rates of all malignancies. In this pilot study, we identify signatures related to survival and treatment response found in circulating
Externí odkaz:
https://doaj.org/article/a12f193c081c4b9a962f187e359203df
Publikováno v:
JCO Oncol Pract
PURPOSE: Patients who carry reduced-activity DPYD polymorphisms have increased fluoropyrimidine (FP) toxicity risk. Although pretreatment DPYD testing is recommended throughout most of Europe, it is not recommended in the United States, and adoption