Výsledky vyhledávání - "Vahri Beaumont"

Akademický článek

Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington’s disease model mice

Autor: Tristano Pancani, Michelle Day, Tatiana Tkatch, David L. Wokosin, Patricia González-Rodríguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D. James Surmeier

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

The corticostriatal dysfunction underlying Huntington’s disease remains incompletely understood. Here, the authors find increased intratelencephalic connectivity resulting from deficient cholinergic transmission in a mouse model of Huntington’s d

Externí odkaz: https://doaj.org/article/9f3da2a974ae4bf7836154aa87353185

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Akademický článek

Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington’s Disease

Autor: Shreaya Chakroborty, Fredric P. Manfredsson, Alexander M. Dec, Peter W. Campbell, Grace E. Stutzmann, Vahri Beaumont, Anthony R. West

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Huntington’s disease (HD) results from abnormal expansion in CAG trinucleotide repeats within the HD gene, a mutation which leads to degeneration of striatal medium-sized spiny neurons (MSNs), deficits in corticostriatal transmission, and loss of m

Externí odkaz: https://doaj.org/article/e7b1c0789f0a4898965484e91efeacaf

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Akademický článek

Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis).

Autor: Jane S Sutcliffe, Vahri Beaumont, James M Watson, Chang Sing Chew, Maria Beconi, Daniel M Hutcheson, Celia Dominguez, Ignacio Munoz-Sanjuan

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102449 (2014)

Cyclic adenosine monophosphate (cAMP) signalling plays an important role in synaptic plasticity and information processing in the hippocampal and basal ganglia systems. The augmentation of cAMP signalling through the selective inhibition of phosphodi

Externí odkaz: https://doaj.org/article/9a4e3bbf7a6042d28ac2f2f8351e4140

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Akademický článek

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

Publikováno v: PLoS Biology, Vol 11, Iss 11, p e1001717 (2013)

Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused

Externí odkaz: https://doaj.org/article/36f0a78b62114715a37984063f3cb2d9

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Akademický článek

HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo.

Autor: Michal Mielcarek, Tamara Seredenina, Matthew P Stokes, Georgina F Osborne, Christian Landles, Linda Inuabasi, Sophie A Franklin, Jeffrey C Silva, Ruth Luthi-Carter, Vahri Beaumont, Gillian P Bates

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80849 (2013)

Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone de

Externí odkaz: https://doaj.org/article/b5485e4f250441ab8eb9ed5c1535835b

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Akademický článek

Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44498 (2012)

Histone deacetylase (HDAC) inhibitors have received considerable attention as potential therapeutics for a variety of cancers and neurological disorders. Recent publications on a class of pimelic diphenylamide HDAC inhibitors have highlighted their p

Externí odkaz: https://doaj.org/article/65e55963f962453d81bddb172d9b42fa

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Akademický článek

Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.

Autor: Taneli Heikkinen, Kimmo Lehtimäki, Nina Vartiainen, Jukka Puoliväli, Susan J Hendricks, Jack R Glaser, Amyaouch Bradaia, Kristian Wadel, Chrystelle Touller, Outi Kontkanen, Juha M Yrjänheikki, Bruno Buisson, David Howland, Vahri Beaumont, Ignacio Munoz-Sanjuan, Larry C Park

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50717 (2012)

Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene (HTT) mutation that causes the disease, several mouse lines have been

Externí odkaz: https://doaj.org/article/1175932203944c0d96212f3286b6ccdd

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Akademický článek

Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists.

Autor: Marco Orru, Jana Bakešová, Marc Brugarolas, César Quiroz, Vahri Beaumont, Steven R Goldberg, Carme Lluís, Antoni Cortés, Rafael Franco, Vicent Casadó, Enric I Canela, Sergi Ferré

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16088 (2011)

Striatal adenosine A(2A) receptors (A(2A)Rs) are highly expressed in medium spiny neurons (MSNs) of the indirect efferent pathway, where they heteromerize with dopamine D(2) receptors (D(2)Rs). A(2A)Rs are also localized presynaptically in cortico-st

Externí odkaz: https://doaj.org/article/05fec735021e4bc3a36c0dc6e7096f8f

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