Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vahan Akullian"'
Autor:
John P. Mallamo, Eissenstat Ma, David Cutcliffe, Philip M. Carabateas, Thomas R. Bailey, Guy D. Diana, Daniel C. Pevear, Paul J. Kowalczyk, Vahan Akullian
Publikováno v:
Journal of Medicinal Chemistry. 35:4628-4633
A variety of heterocyclic analogs of Win 54954 have been synthesized and tested in vitro against human rhinovirus type 14 (HRV-14) in a plaque reduction assay. The more active compounds were tested against 14 additional serotypes, and the concentrati
Autor:
Richard C. Oglesby, Michael J. Otto, David Cutcliffe, Mark A. McKinlay, Guy D. Diana, Vahan Akullian, John P. Mallamo
Publikováno v:
Journal of medicinal chemistry. 32(2)
A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes. A QSAR study revealed that the mean MIC (MIC) against five rhinovirus serotypes corr
Publikováno v:
Journal of medicinal chemistry. 28(12)
A series of [[(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles has been synthesized and evaluated as antipicornavirus agents. The effect of alkyl groups in the 4- and 5-position of the oxazoline ring, as well as the alkyl chain length, on antiviral a
Autor:
Edward G. Maliski, Philip M. Carabateas, John P. Mallamo, Guy D. Diana, Vahan Akullian, Stephen J. Michalec, Richard C. Oglesby, David Cutcliffe, Michael J. Otto, Mark A. McKinlay
Publikováno v:
Journal of medicinal chemistry. 30(2)
A series of substituted phenyl analogues of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles has been synthesized and evaluated in vitro against several human rhinovirus (HRV) serotypes. Substituents in the 2-position greatly enhanced
Autor:
Philip M. Carabateas, Edward G. Maliski, Richard C. Oglesby, Michael J. Otto, Mark A. McKinlay, John P. Mallamo, Guy D. Diana, David Cutcliffe, Stephen J. Michalec, Vahan Akullian
Publikováno v:
ChemInform. 18
A series of substituted phenyl analogues of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles has been synthesized and evaluated in vitro against several human rhinovirus (HRV) serotypes. Substituents in the 2-position greatly enhanced
Publikováno v:
Chemischer Informationsdienst. 17
A series of [[(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles has been synthesized and evaluated as antipicornavirus agents. The effect of alkyl groups in the 4- and 5-position of the oxazoline ring, as well as the alkyl chain length, on antiviral a
Publikováno v:
Synthesis. 1981:357-358