Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Vahan, Aslanyan"'
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Akademický článek
A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s Disease
Autor: Douglas Galasko, Martin R. Farlow, Brendan P. Lucey, Lawrence S. Honig, Donald Elbert, Randall Bateman, Jeremiah Momper, Ronald G. Thomas, Robert A. Rissman, Judy Pa, Vahan Aslanyan, Archana Balasubramanian, Tim West, Maria Maccecchini, Howard H. Feldman
Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Amyloid beta protein (Aβ) is a treatment target in Alzheimer’s Disease (AD). Lowering production of its parent protein, APP, has benefits in preclinical models. Posiphen, an orally administered small molecule, binds to an iron-
Externí odkaz: https://doaj.org/article/e42d62be4d5d45feab248f4b5d8078a5
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2
Akademický článek
Generalizability of cognitive results from clinical trial participants to an older adult population: Addressing external validity
Autor: Vahan Aslanyan, Judy Pa, Howard N. Hodis, Jan St. John, Naoko Kono, Victor W. Henderson, Wendy J Mack, for the Alzheimer's Disease Neuroimaging Initiative#
Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Introduction Study inclusion criteria and recruitment practices limit the generalizability of randomized‐controlled trial (RCT) results. Statistical modeling could enhance generalizability of outcomes. To illustrate this, the cognition–d
Externí odkaz: https://doaj.org/article/96b303c33d3c4c709e80bdc26303a0fa
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3
Akademický článek
Protective effects of sleep duration and physical activity on cognitive performance are influenced by β-amyloid and brain volume but not tau burden among cognitively unimpaired older adults
Autor: Vahan Aslanyan, Nancy Ortega, Laura Fenton, Theresa M. Harrison, Rema Raman, Wendy J. Mack, Judy Pa
Publikováno v: NeuroImage: Clinical, Vol 39, Iss , Pp 103460- (2023)
Background and objectives: Sleep and physical activity have gained traction as modifiable risk factors for Alzheimer’s disease. Sleep duration is linked to amyloid-β clearance while physical activity is associated with brain volume maintenance. We
Externí odkaz: https://doaj.org/article/90ed915b9ab646baba30e89d66057691
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4
Variability in objective sleep is associated with Alzheimer’s pathology and cognition
Autor: Laura Fenton, A Lisette Isenberg, Vahan Aslanyan, Daniel Albrecht, Joey A Contreras, Joy Stradford, Teresa Monreal, Judy Pa
Publikováno v: Brain Commun
Both sleep duration and sleep efficiency have been associated with risk of Alzheimer’s disease, suggesting that interventions to promote optimal sleep may be a way to reduce Alzheimer’s disease risk. However, studies often focus on average sleep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e925d4250289c632ece50e95dd08964
https://doi.org/10.1093/braincomms/fcad031
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9
Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults
Autor: Kaitlin B Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M Simone, Jennifer S Rabin, Renaud La Joie, Adam M Brickman, Kristen Dams-O’Connor, Priya Palta, Raj G Kumar, Kristen M George, Claudia L Satizabal, Julie Schneider, Judy Pa
Publikováno v: Brain
Females show a disproportionate burden of Alzheimer’s disease pathology and higher Alzheimer’s disease dementia prevalences compared to males, yet the mechanisms driving these vulnerabilities are unknown. There is sexual dimorphism in immunologic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5387e0c14f3c08dc765631a26bee63af
https://pubmed.ncbi.nlm.nih.gov/36052679
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10
Higher baseline levels of CSF inflammation increase risk of incident mild cognitive impairment and Alzheimer's disease dementia
Autor: Joey A, Contreras, Vahan, Aslanyan, Daniel S, Albrecht, Wendy J, Mack, Judy, Pa
Publikováno v: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 14
Few studies have investigated how neuroinflammation early in the disease course may affect Alzheimer's disease (AD) progression over time despite evidence that neuroinflammation is associated with AD.Research participants with cerebrospinal fluid (CS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1425998efa142874ec422aebecbbc6be
https://doi.org/10.1002/dad2.12346
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