Metabolism-Driven High-Throughput Cancer Identification with GLUT5-Specific Molecular Probes

Autor: Srinivas Kannan, Vagarshak V. Begoyan, Joseph R. Fedie, Shuai Xia, Łukasz J. Weseliński, Marina Tanasova, Smitha Rao

Publikováno v: Biosensors, Vol 8, Iss 2, p 39 (2018)

Point-of-care applications rely on biomedical sensors to enable rapid detection with high sensitivity and selectivity. Despite advances in sensor development, there are challenges in cancer diagnostics. Detection of biomarkers, cell receptors, circul

Externí odkaz: https://doaj.org/article/ec983e6b4f054f47aa48c942a0543099

Targeting Sugar Uptake and Metabolism for Cancer Identification and Therapy: An Overview

Autor: Vagarshak V. Begoyan, Lukasz Jan Weselinski, Marina Tanasova

Publikováno v: Current Topics in Medicinal Chemistry. 18:467-483

Metabolic deregulations have emerged as a cancer characteristic, opening a broad avenue for strategies and tools to target cancer through sugar uptake and metabolism. High expression levels of sugar transporters in cancer cells offered glycoconjugati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e925cd8d422207703eadf5ef729bdd86
https://doi.org/10.2174/1568026618666180523110837

Tuning Cross-Coupling Approaches to C3 Modification of 3-Deazapurines

Autor: Vagarshak V. Begoyan, Marina Tanasova, Łukasz J. Weseliński, Alexis Ferrier

Publikováno v: ACS Omega
ACS Omega, Vol 2, Iss 10, Pp 7002-7015 (2017)

A general approach to C3 modification of purine scaffold through various types of cross-coupling reactions has been established. Tuning substrate electronics and reaction conditions resulted in the development of highly efficient sp2–sp, sp2–sp2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29eae7f74ad7873384937ce52887edc
https://pubmed.ncbi.nlm.nih.gov/30023537

Coumarins: Spectroscopic measurements and first principles calculations of C4-substituted 7-aminocoumarins

Autor: Max Seel, Vagarshak V. Begoyan, Kevin Waters, Marina Tanasova, Shraddha Singh, Ravindra Pandey

Publikováno v: Journal of Physical Organic Chemistry. 31:e3852

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcab1fd793d554a7cda0d9e630ef26ae
https://doi.org/10.1002/poc.3852

Electrophilic oligodeoxynucleotide synthesis using dM-Dmoc for amino protection.

Autor: Shahsavari S; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA., Eriyagama DNAM; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA., Halami B; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA., Begoyan V; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA., Tanasova M; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA., Chen J; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA., Fang S; Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA.

Publikováno v: Beilstein journal of organic chemistry [Beilstein J Org Chem] 2019 May 20; Vol. 15, pp. 1116-1128. Date of Electronic Publication: 2019 May 20 (Print Publication: 2019).