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A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases.

Autor: Tkachenko AG; Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia. Electronic address: agtkachenko@iegm.ru., Kashevarova NM; Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia., Sidorov RY; Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia., Nesterova LY; Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia., Akhova AV; Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia., Tsyganov IV; Laboratory of Microbial Adaptation, Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center, Russian Academy of Sciences, Ural Branch, Goleva 13, Perm, 614081, Perm Krai, Russia; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia., Vaganov VY; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia., Shipilovskikh SA; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia., Rubtsov AE; Perm State University, Bukireva 15, Perm, 614990, Perm Krai, Russia. Electronic address: rubtsov@psu.ru., Malkov AV; Department of Chemistry, Loughborough University Address: University Road, Loughborough, Leicestershire LE11 3TU, UK. Electronic address: a.malkov@lboro.ac.uk.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2021 Oct 21; Vol. 28 (10), pp. 1420-1432.e9. Date of Electronic Publication: 2021 Feb 22.

Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction.

Autor: Shipilovskikh SA; Department of Chemistry, Perm State University , Bukireva 15, Perm 614990, Russia., Vaganov VY; Department of Chemistry, Perm State University , Bukireva 15, Perm 614990, Russia., Denisova EI; Department of Chemistry, Perm State University , Bukireva 15, Perm 614990, Russia., Rubtsov AE; Department of Chemistry, Perm State University , Bukireva 15, Perm 614990, Russia., Malkov AV; Department of Chemistry, Loughborough University , Loughborough, Leicestershire LE11 3TU, U.K.; Department of Organic Chemistry, RUDN University , 6 Miklukho-Maklaya Street, Moscow 117198, Russia.

Publikováno v: Organic letters [Org Lett] 2018 Feb 02; Vol. 20 (3), pp. 728-731. Date of Electronic Publication: 2018 Jan 10.