Point-of-care lung ultrasonography for pneumonia in children

Autor: Kleiber, N, Calvier, E, Mooij, MG, Krekels, EHJ, Vaes, WH, Windhorst, AD, Hendrikse, H, Tibboel, D, Knibbe, CAJ, de Wildt, SN

Publikováno v: Archives of Disease in Childhood, 104(1), 2-3. BMJ Publishing Group
Kleiber, N, Calvier, E, Mooij, MG, Krekels, EHJ, Vaes, WH, Windhorst, AD, Hendrikse, H, Tibboel, D, Knibbe, CAJ & de Wildt, SN 2019, ' Point-of-care lung ultrasonography for pneumonia in children : Does size really matter? ', Archives of Disease in Childhood, vol. 104, no. 1, pp. 2-3 . https://doi.org/10.1136/archdischild-2018-315196

Lung ultrasonography for the diagnosis of pneumonia has been around since as early as 1970,1 although it is only in recent years with the growing interest in point-of-care ultrasound that more studies have been published with regard to its use in chi

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Dose-linearity of the pharmacokinetics of an intravenous [ ¹⁴ C]midazolam microdose in children.

Autor: van Groen BD; Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Vaes WH; TNO, Zeist, The Netherlands., Park BK; University of Liverpool, Liverpool, UK., Krekels EHJ; Leiden University, Leiden, The Netherlands., van Duijn E; TNO, Zeist, The Netherlands., Kõrgvee LT; University of Tartu, Tartu, Estonia., Maruszak W; Pharmaceutical Research Institute, Warsaw, Poland., Grynkiewicz G; Pharmaceutical Research Institute, Warsaw, Poland., Garner RC; Garner Consulting, York, UK., Knibbe CAJ; Leiden University, Leiden, The Netherlands.; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, the Netherlands., Tibboel D; Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., de Wildt SN; Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Radboud University, Nijmegen, the Netherlands., Turner MA; University of Liverpool, Liverpool, UK.

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Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life.

Autor: Mooij MG; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., van de Steeg E; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., van Rosmalen J; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., Windster JD; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., de Koning BA; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., Vaes WH; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., van Groen BD; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., Tibboel D; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., Wortelboer HM; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.)., de Wildt SN; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (M.G.M., J.D.W., B.D.G., D.T., S.N.W.); Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (J.R.); Division of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (B.A.E.K.); TNO, Zeist, The Netherlands (E.v.d.S., H.M.W., W.H.J.V.); and Department of Pharmacology and Toxicology, Radboud University, Nijmegen, The Netherlands (S.N.d.W.) s.dewildt@erasmusmc.nl.

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To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics.

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Autor: Vlaming ML; TNO, Zeist, The Netherlands, UK., van Duijn E; TNO, Zeist, The Netherlands, UK., Dillingh MR; Centre for Human Drug Research, Leiden, The Netherlands, UK., Brands R; AMRIF BV, Wageningen, The Netherlands, UK., Windhorst AD; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, UK., Hendrikse NH; Department of Pharmacy and Clinical Pharmacology, VU University Medical Center, Amsterdam, The Netherlands, UK., Bosgra S; TNO, Zeist, The Netherlands, UK., Burggraaf J; Centre for Human Drug Research, Leiden, The Netherlands, UK., de Koning MC; TNO, Zeist, The Netherlands, UK., Fidder A; TNO, Zeist, The Netherlands, UK., Mocking JA; TNO, Zeist, The Netherlands, UK., Sandman H; TNO, Zeist, The Netherlands, UK., de Ligt RA; TNO, Zeist, The Netherlands, UK., Fabriek BO; TNO, Zeist, The Netherlands, UK., Pasman WJ; TNO, Zeist, The Netherlands, UK., Seinen W; AMRIF BV, Wageningen, The Netherlands, UK.; Utrecht University, Utrecht, The Netherlands, UK., Alves T; GenIBET/IBET, Oeiras, Portugal., Carrondo M; GenIBET/IBET, Oeiras, Portugal., Peixoto C; GenIBET/IBET, Oeiras, Portugal., Peeters PA; Centre for Human Drug Research, Leiden, The Netherlands, UK., Vaes WH; TNO, Zeist, The Netherlands, UK.

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