Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Vadym V. Levterov"'
Autor:
Vadym V. Levterov, Yaroslav Panasiuk, Kateryna Sahun, Oleksandr Stashkevych, Valentyn Badlo, Oleh Shablykin, Iryna Sadkova, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yuliia Holota, Leonid Lachmann, Petro Borysko, Kateryna Horbatok, Iryna Bodenchuk, Yuliia Bas, Dmytro Dudenko, Pavel K. Mykhailiuk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract The phenyl ring is a basic structural element in chemistry. Here, we show the design, synthesis, and validation of its new saturated bioisostere with improved physicochemical properties − 2-oxabicyclo[2.2.2]octane. The design of the struct
Externí odkaz:
https://doaj.org/article/40ae1c7eff7f48309d4252061fceaf57
Autor:
Oleksandr O. Grygorenko, Ivan S. Kondratov, Illia O. Feskov, Bohdan V. Vashchenko, Günter Haufe, Bohdan O. Golub, Vadym V. Levterov
Publikováno v:
European Journal of Organic Chemistry. 2020:4755-4767
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d4d95d95b52748d8c0085de76360ef
https://doi.org/10.1002/ejoc.202000733
https://doi.org/10.1002/ejoc.202000733
Publikováno v:
Angewandte Chemie. 132:7228-7234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb5be783f89de710bb83d805d3937f87
https://doi.org/10.1002/ange.202000548
https://doi.org/10.1002/ange.202000548
Autor:
Pavel K. Mykhailiuk, Roman M. Bychek, Sergey Zozulya, Vadym V. Levterov, Yuliya P Bas, Valeriia Hutskalova, Olga A. Zaporozhets
Publikováno v:
The Journal of Organic Chemistry. 84:15106-15117
A practical synthetic approach to the difluoro-substituted bicyclo[1.1.1]pentanes was developed. The key step was an addition of difluorocarbene (:CF2) to electron-rich bicyclo[1.1.0]butanes by the CF3TMS/NaI system. The obtained difluoro-bicyclo[1.1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ba67f019615f023a4c6e7c69993e04
https://doi.org/10.1021/acs.joc.9b01947
https://doi.org/10.1021/acs.joc.9b01947
Publikováno v:
Angewandte Chemie (International ed. in English). 59(18)
A new generation of saturated benzene mimetics, 2-oxabicyclo[2.1.1]hexanes, was developed. These compounds were designed as analogues of bicyclo[1.1.1]pentane with an improved water solubility. Crystallographic analysis of 2-oxabicyclo[2.1.1]hexanes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1502eaf3c605397ef1590e34f54ddda5
https://pubmed.ncbi.nlm.nih.gov/32060990
https://pubmed.ncbi.nlm.nih.gov/32060990
Autor:
Andrey A. Tolmachev, Pavel K. Mykhailiuk, Iryna V. Sadkova, Roman M. Bychek, Vadym V. Levterov
Publikováno v:
Chemistry - A European Journal. 24:12291-12297
Difluorocyclopropane-containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3 /NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd33d27cb5955942e3524aae8ae76875
https://doi.org/10.1002/chem.201705708
https://doi.org/10.1002/chem.201705708
Publikováno v:
Angewandte Chemie International Edition. 59:6942-6942
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dc1019753af3f157e4f42777fedcf5b
https://doi.org/10.1002/anie.202004146
https://doi.org/10.1002/anie.202004146
Publikováno v:
Angewandte Chemie. 132:7006-7006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86ec44b85530e61d5315fbbd072b0a6
https://doi.org/10.1002/ange.202004146
https://doi.org/10.1002/ange.202004146
Autor:
Pavel K. Mykhailiuk, Petro Borysko, Andrey A. Tolmachev, Sergey Zozulya, Vadym V. Levterov, Iryna V. Sadkova, Oleg M. Michurin
Publikováno v:
The Journal of organic chemistry. 83(23)
A practical synthesis of 2,4-methanopyrrolidines was elaborated. The key synthetic step was an intramolecular photochemical [2 + 2]-cycloaddition of an acrylic acid derivative in flow. In spite of a higher molecular weight, 2,4-methanopyrrolidines we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f26990947c5527c55170e08a386b8ac
https://pubmed.ncbi.nlm.nih.gov/30358395
https://pubmed.ncbi.nlm.nih.gov/30358395
Publikováno v:
Synthesis. 2011:1243-1248
An expedient approach to the difluoromethylation of imidazoles- andbenzimidazoles has been developed. The key feature of the procedureis the gradual generation of the difluoromethylation reagent inthe reaction mixture, which is achieved by the simult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf94cba913f45d1ffe8b5a4fbea5ec63
https://doi.org/10.1055/s-0030-1258470
https://doi.org/10.1055/s-0030-1258470