Výsledky vyhledávání - "Vadiraja B Bhat"

Akademický článek

Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma.

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17177 (2011)

Pancreatic Adenocarcinoma (PDAC), the fourth highest cause of cancer related deaths in the United States, has the most aggressive presentation resulting in a very short median survival time for the affected patients. Early detection of PDAC is confou

Externí odkaz: https://doaj.org/article/5c58f13c4990418e949ac96c90b1b6c2

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A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis

Autor: Sridhar Radhakrishnan, Abigail Sido, Vadiraja B. Bhat, Elisabeth Eriksson, Qiang Li, Lavanya Reddivari, Sung Woo Kim, Frank Shen, Jairam Vanamala

Publikováno v: The Journal of Nutritional Biochemistry. 43:11-17

Studies have shown a causal link between high-calorie diet (HCD) and colon cancer. However, molecular mechanisms are not fully elucidated. To understand etiology of HCD-induced colon carcinogenesis, we screened 10 pathways linked to elevated colonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9ae5d67bb54fb398ab811471b59df6
https://doi.org/10.1016/j.jnutbio.2017.01.012

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S -nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration

Autor: Kodihalli C. Ravindra, Alexi Nott, Steven R. Tannenbaum, Li-Huei Tsai, Uthpala Seneviratne, John S. Wishnok, Vadiraja B. Bhat

Publikováno v: Proceedings of the National Academy of Sciences. 113:4152-4157

Protein S-nitrosation (SNO-protein), the nitric oxide-mediated posttranslational modification of cysteine thiols, is an important regulatory mechanism of protein function in both physiological and pathological pathways. A key first step toward elucid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85890118853b7a328cc39ab38348fc0e
https://doi.org/10.1073/pnas.1521318113

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Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function

Autor: Guanyu Gong, Steven R. Tannenbaum, Xin Wang, Haitham Amal, Boaz Barak, John S. Wishnok, Vadiraja B. Bhat, Brian A. Joughin, Guoping Feng

Publikováno v: Mol Psychiatry
PMC

Mutation in the SHANK3 human gene leads to different neuropsychiatric diseases including Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome. Shank3 disruption in mice leads to dysfunction of synaptic transmission,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac34db96f206a7c678c0f7df673da300
https://pubmed.ncbi.nlm.nih.gov/29988084

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Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance

Autor: Sung Woo Kim, Lavanya Reddivari, Rob Knight, Venkata Charepalli, Frank Shen, Vadiraja B. Bhat, Sridhar Radhakrishnan, Jairam Vanamala, Matam Vijay-Kumar, Xia Xiao, Elisabeth Eriksson, Qiang Li

Publikováno v: Cancer prevention research (Philadelphia, Pa.), vol 10, iss 8

Basal colonic crypt stem cells are long lived and play a role in colon homeostasis. Previous evidence has shown that high-calorie diet (HCD) enhances colonic stem cell numbers and expansion of the proliferative zone, an important biomarker for colon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eaa3c662b34f27f8f293cc18f84e5c0
https://escholarship.org/uc/item/8dw3t1k3

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Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation

Autor: Jerry W. Simecka, Riyaz Basha, Vadiraja B. Bhat, Robert W. Holloway, Ekamber Kariali, Liz Daniel, Susan B. Ingersoll, Umesh T. Sankpal, Sarfraz Ahmad, Jamboor K. Vishwanatha

Publikováno v: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(10)

The expression of specificity protein 1 (Sp1) and survivin was evaluated in clinical specimens of epithelial ovarian cancer (EOC) patients. When compared to normal tissue, EOC samples showed high expression of Sp1 and survivin using qPCR (Sp1: ∼2-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e017fb93613d1a44b99499ef9d6921
https://pubmed.ncbi.nlm.nih.gov/27581819

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Low abundance protein enrichment for discovery of candidate plasma protein biomarkers for early detection of breast cancer

Autor: Andrew A. Quong, Michael Gormley, Anne L. Rosenberg, Rong Meng, Vadiraja B. Bhat

Publikováno v: Journal of Proteomics. 75:366-374

Molecular biomarkers of early stage breast cancer may improve the sensitivity and specificity of diagnosis. Plasma biomarkers have additional value in that they can be monitored with minimal invasiveness. Plasma biomarker discovery by genome-wide pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eedefb0387d5935c1af2d8a313d110a
https://doi.org/10.1016/j.jprot.2011.07.030

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