Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Vadim V Sumbayev"'
Autor:
Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. Recent evidence de
Externí odkaz:
https://doaj.org/article/fda2b5b4fd00456fae87452cb2fa1b43
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34259 (2012)
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogeni
Externí odkaz:
https://doaj.org/article/5d1983117cd6428b9f3aa63b052f8d5f
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22502 (2011)
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117. SCF-Kit signalling is crucial for the survival, proliferation and differentiation of hematopoie
Externí odkaz:
https://doaj.org/article/291aa65c68fc45d887a2da9f3c5894ae
Autor:
Gaetan Aime Noubissi Nzeteu, Stephanie Schlichtner, Sulamith David, Aylin Ruppenstein, Elizaveta Fasler-Kan, Ulrike Raap, Vadim V. Sumbayev, Bernhard F. Gibbs, N. Helge Meyer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Recently, the V-domain immunoglobulin suppressor of T-cell activation (VISTA) was identified as a negative immune checkpoint regulator (NCR) that is mainly expressed in hematopoietic cells. Preclinical studies have shown that VISTA blockade results i
Externí odkaz:
https://doaj.org/article/efc8ca0dc2af46be88b2cef44b04ee93
Autor:
Inna M. Yasinska, N. Helge Meyer, Stephanie Schlichtner, Rohanah Hussain, Giuliano Siligardi, Maxwell Casely-Hayford, Walter Fiedler, Jasmin Wellbrock, Cloe Desmet, Luigi Calzolai, Luca Varani, Steffen M. Berger, Ulrike Raap, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic lymphoid cells. This includes the inactivation of natural killer (NK) cells a
Externí odkaz:
https://doaj.org/article/fde3b7a88f6a40a58578f302b9d89082
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/b01ba36cc30f438f8456deea9d2fc3ff
Autor:
Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
EBioMedicine, Vol 22, Iss C, Pp 44-57 (2017)
Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which
Externí odkaz:
https://doaj.org/article/e004d7f74c5c43a19b8c11d1701ce852
Autor:
Inna M. Yasinska, Svetlana S. Sakhnevych, Ludmila Pavlova, Anette Teo Hansen Selnø, Ana Maria Teuscher Abeleira, Ouafa Benlaouer, Isabel Gonçalves Silva, Marianne Mosimann, Luca Varani, Marco Bardelli, Rohanah Hussain, Giuliano Siligardi, Dietmar Cholewa, Steffen M. Berger, Bernhard F. Gibbs, Yuri A. Ushkaryov, Elizaveta Fasler-Kan, Elena Klenova, Vadim V. Sumbayev
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease. We have recently reported that the immune receptor Tim-3 and its natural ligand ga
Externí odkaz:
https://doaj.org/article/83b5108e523d4c67ad0de9fa49513b57
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human
Externí odkaz:
https://doaj.org/article/04bf3f042a8c4aa5aeb752fb467d9380
Autor:
Inna M. Yasinska, Luigi Calzolai, Ulrike Raap, Rohanah Hussain, Giuliano Siligardi, Vadim V. Sumbayev, Bernhard F. Gibbs
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Calcineurin inhibitors potentially prevent pro-allergic mediator release from basophils and mast cells but are rarely used systemically due to ubiquitous expressions of target signaling proteins. However, specific targeting of allergic effector cells
Externí odkaz:
https://doaj.org/article/3b65a95480b44f13895dedb94fdc3556