Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Vadim V, Fedorov"'
Autor:
Jichao Zhao, Roshan Sharma, Anuradha Kalyanasundaram, James Kennelly, Jieyun Bai, Ning Li, Alexander Panfilov, Vadim V Fedorov
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 12, p e1011708 (2023)
The sinoatrial node (SAN), the primary pacemaker of the heart, is responsible for the initiation and robust regulation of sinus rhythm. 3D mapping studies of the ex-vivo human heart suggested that the robust regulation of sinus rhythm relies on speci
Externí odkaz:
https://doaj.org/article/52a3118755d14e33a7bc3850f2a3f789
Autor:
Ning Li, Esthela Artiga, Anuradha Kalyanasundaram, Brian J. Hansen, Amy Webb, Maciej Pietrzak, Brandon Biesiadecki, Bryan Whitson, Nahush A. Mokadam, Paul M. L. Janssen, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Vadim V. Fedorov
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction, which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations are associated with HF progression. However, the transcriptome
Externí odkaz:
https://doaj.org/article/d1f3400a06c3430697951538c406b0ec
Autor:
Ning Li, Anuradha Kalyanasundaram, Brian J. Hansen, Esthela J. Artiga, Roshan Sharma, Suhaib H. Abudulwahed, Katelynn M. Helfrich, Galina Rozenberg, Pei-Jung Wu, Stanislav Zakharkin, Sandor Gyorke, Paul ML. Janssen, Bryan A. Whitson, Nahush A. Mokadam, Brandon J. Biesiadecki, Federica Accornero, John D. Hummel, Peter J. Mohler, Halina Dobrzynski, Jichao Zhao, Vadim V. Fedorov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their
Externí odkaz:
https://doaj.org/article/f630452532e74b488261b252cd5af083
Autor:
Anuradha, Kalyanasundaram, Ning, Li, Ralph S, Augostini, Raul, Weiss, John D, Hummel, Vadim V, Fedorov
Publikováno v:
Heart Rhythm. 20:122-133
The sinoatrial node (SAN) is the primary pacemaker of the human heart. It is a single, elongated, 3-dimensional (3D) intramural fibrotic structure located at the junction of the superior vena cava intercaval region bordering the crista terminalis (CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1188fab93ae1e365451092de119efccd
https://doi.org/10.1016/j.hrthm.2022.08.039
https://doi.org/10.1016/j.hrthm.2022.08.039
Autor:
Brian J. Hansen, Jichao Zhao, Katelynn M. Helfrich, Ning Li, Alexander Iancau, Alexander M. Zolotarev, Stanislav O. Zakharkin, Anuradha Kalyanasundaram, Megan Subr, Nawshin Dastagir, Roshan Sharma, Esthela J. Artiga, Nicholas Salgia, Mustafa M. Houmsse, Omar Kahaly, Paul M. L. Janssen, Peter J. Mohler, Nahush A. Mokadam, Bryan A. Whitson, Muhammad R. Afzal, Orlando P. Simonetti, John D. Hummel, Vadim V. Fedorov
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 19 (2020)
Background Atrial fibrillation (AF) driver mechanisms are obscured to clinical multielectrode mapping approaches that provide partial, surface‐only visualization of unstable 3‐dimensional atrial conduction. We hypothesized that transient modulati
Externí odkaz:
https://doaj.org/article/8f6472004e244b198cbef26b3fa05dbc
Autor:
Maria Petkova, Andrew J. Atkinson, Joseph Yanni, Luke Stuart, Abimbola J. Aminu, Alexandra D. Ivanova, Ksenia B. Pustovit, Connor Geragthy, Amy Feather, Ning Li, Yu Zhang, Delvac Oceandy, Filip Perde, Peter Molenaar, Alicia D’Souza, Vadim V. Fedorov, Halina Dobrzynski
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 20 (2020)
Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distinctive action potential morphology with spontaneous diastolic depolarization because of a unique expression of ion channels and Ca2+‐handling proteins. M
Externí odkaz:
https://doaj.org/article/375542e1a34747dcbe6c389f36654b67
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007678 (2020)
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a major cause of stroke and morbidity. Recent genome-wide association studies have shown that paired-like homeodomain transcription factor 2 (Pitx2) to be strongly associ
Externí odkaz:
https://doaj.org/article/dffaec66280f4b699bf2f64940a09ff8
Autor:
Ning Li, Brian J. Hansen, James Kennelly, Anuradha Kalyanasundaram, Adel Kanaan, Orlando P. Simonetti, Peter J. Mohler, Bryan A. Whitson, John D. Hummel, Jichao Zhao, Vadim V. Fedorov
Publikováno v:
Circulation: Arrhythmia and Electrophysiology. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da4cbd84c46a3ebb18ed42ad79d9c9b
https://doi.org/10.1161/circep.122.011528
https://doi.org/10.1161/circep.122.011528
Autor:
Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Tropo
Externí odkaz:
https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
Autor:
Ning Li, Brian Hansen, Anuradha Kalyanasundaram, James Kennelly, Peter J. Mohler, Orlando P. Simonetti, Jichao Zhao, Vadim V. Fedorov
Publikováno v:
Heart Rhythm. 20:S66-S67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d532056e8324bdfb85b9b162bb8a3895
https://doi.org/10.1016/j.hrthm.2023.03.341
https://doi.org/10.1016/j.hrthm.2023.03.341