Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Vadim Shteyler"'
Autor:
Mou Ng, Victor Adler, Michael E. Zenilman, Kelley A. Sookraj, Kamran Ikram, Martin H. Bluth, Wilbur B. Bowne, Stephan Bradu, Sunming Lou, Raqibul Hannan, Jesco Koenke, Ehsan Sarafraz-Yazdi, Josef Michl, Michael Harding, Michael Vishnevetsky, Vadim Shteyler, Matthew R. Pincus, Paul W. Brandt-Rauf
Publikováno v:
Annals of Surgical Oncology. 15:3588-3600
PNC-27 and PNC-28 are p53-derived peptides from the human double minute (hdm-2) binding domain attached to penetratin. These peptides induce tumor cell necrosis of cancer cells, but not normal cells. The anticancer activity and mechanism of PNC-28 (p
Autor:
Hunaiz Patel, Victor Adler, Ehsan Sarafraz-Yazdi, Vernon Wu, Josef Michl, Matthew R. Pincus, Wilbur B. Bowne, Paul W. Brandt-Rauf, Kelley A. Sookraj, Michael E. Zenilman, Vadim Shteyler, William Oxbury
The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by inducing membranolysis. We find that ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3234eb36b1e1ab8c05a30028d6a6c6e1
https://europepmc.org/articles/PMC2836618/
https://europepmc.org/articles/PMC2836618/
Autor:
Vernon Wu, Vadim Shteyler, Kelley A. Sookraj, Matthew R. Pincus, Alison J. North, Wilbur B. Bowne, Victor Adler, Allison Wagreich, Ehsan Sarafraz-yazdi, Josef Michl
Publikováno v:
Cancer Research. 70:5770-5770
PNC-27 anti-cancer peptide, derived from the MDM2 binding site of p53 and linked to a membrane residency peptide (MRP), has been shown to cause necrosis of cancer cells without affecting untransformed cells. PNC-27 was also able to eradicate pancreat