Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Vadim Sakk"'
Autor:
Sara Montserrat-Vazquez, Noelle J. Ali, Francesca Matteini, Javier Lozano, Tu Zhaowei, Eva Mejia-Ramirez, Gina Marka, Angelika Vollmer, Karin Soller, Mehmet Sacma, Vadim Sakk, Loris Mularoni, Jan Philipp Mallm, Mireya Plass, Yi Zheng, Hartmut Geiger, M. Carolina Florian
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-17 (2022)
Abstract One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking. He
Externí odkaz:
https://doaj.org/article/a4bb8c5a146d41029eb29433f0022be5
Autor:
Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSC). We report increased frequencies of HSC, hematopoietic progenitor cells and lineage negative cells in the elderly but a decreased frequency of multi-lymphoi
Externí odkaz:
https://doaj.org/article/f412a1c316754eae9e008f8f750efa0f
Autor:
Andreas Brown, Desiree Schuetz, Yang Han, Deidre Daria, Kalpana J. Nattamai, Karina Eiwen, Vadim Sakk, Johannes Pospiech, Thomas Saller, Gary van Zant, Wolfgang Wagner, Hartmut Geiger
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/a8b73ebd065f46b89fa1a0c24c629585
Autor:
Andreas Brown, Johannes Pospiech, Karina Eiwen, Darren J. Baker, Bettina Moehrle, Vadim Sakk, Kalpana Nattamai, Mona Vogel, Ani Grigoryan, Hartmut Geiger
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1359-1368 (2017)
Summary: The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells. While leukemia is frequently driven by transformed hematopoietic stem a
Externí odkaz:
https://doaj.org/article/a94c74c4e25547e693b8eccc7440ef5e
Autor:
M Carolina Florian, Markus Klose, Mehmet Sacma, Jelena Jablanovic, Luke Knudson, Kalpana J Nattamai, Gina Marka, Angelika Vollmer, Karin Soller, Vadim Sakk, Nina Cabezas-Wallscheid, Yi Zheng, Medhanie A Mulaw, Ingmar Glauche, Hartmut Geiger
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2003389 (2018)
Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control prot
Externí odkaz:
https://doaj.org/article/edd84f3477ed491c831b529cfab0e5ea
Autor:
Yang Han, Monika Eipel, Julia Franzen, Vadim Sakk, Bertien Dethmers-Ausema, Laura Yndriago, Ander Izeta, Gerald de Haan, Hartmut Geiger, Wolfgang Wagner
Publikováno v:
eLife, Vol 7 (2018)
Epigenetic clocks for mice were generated based on deep-sequencing analysis of the methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by pyrosequencing at only three CG dinucleotides (CpGs) in the genes Prima1, Hsf4
Externí odkaz:
https://doaj.org/article/d4d5e7d2aeee448d84054cba06812065
Autor:
Mona, Vogel, Bettina, Möhrle, Vadim, Sakk, Andreas, Brown, Annette, Palmer, Sonja, Braumüller, Markus, Huber-Lang, Andreas, Allgöwer, Jose A, Cancelas, Hartmut, Geiger
Publikováno v:
Shock. 57:260-267
Thoracic trauma is a major cause of mortality due to the associated inflammatory acute respiratory distress syndrome and morbidity due to impaired tissue regeneration. Trauma-induced lung inflammation is characterized by the early recruitment of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f1536b1aaeac0df1c8fb98bdf20674
https://doi.org/10.1097/shk.0000000000001933
https://doi.org/10.1097/shk.0000000000001933
Autor:
Sachin Kumar, Jeffrey D Vassallo, Kalpana J Nattamai, Aishlin Hassan, Rebekah Karns, Angelika Vollmer, Karin Soller, Vadim Sakk, Mehmet Sacma, Travis Nemkov, Angelo D'Alessandro, Hartmut Geiger
Publikováno v:
EMBO reports. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55ace1faf8253303aa4a1a55a1c6a4a
https://doi.org/10.15252/embr.202255373
https://doi.org/10.15252/embr.202255373
Autor:
Mehmet, Saçma, Francesca, Matteini, Medhanie A, Mulaw, Ali, Hageb, Ruzhica, Bogeska, Vadim, Sakk, Angelika, Vollmer, Gina, Marka, Karin, Soller, Michael D, Milsom, Maria Carolina, Florian, Hartmut, Geiger
Publikováno v:
STAR protocols. 3(3)
Quantitative 3D imaging of organ-wide cellular and subcellular components is central for revealing and understanding complex interactions between stem cells and their microenvironment. Here, we present a gentle but fast whole-mount immunofluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c15b7039ee54c36cb8409e0ca8a73f6f
https://pubmed.ncbi.nlm.nih.gov/35769923
https://pubmed.ncbi.nlm.nih.gov/35769923
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Aging-associated leukemia and aging-associated immune remodeling are in part caused by aging of hematopoietic stem cells (HSCs). An increase in the activity of the small RhoGTPase cell division control protein 42 (Cdc42) within HSCs causes aging of H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7570496404892a8327e1019784c5f29
https://doi.org/10.1002/stem.3372
https://doi.org/10.1002/stem.3372