Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Vadim S Ten"'
Autor:
Korapat Mayurasakorn, Zoya V Niatsetskaya, Sergey A Sosunov, Jill J Williams, Hylde Zirpoli, Iliyan Vlasakov, Richard J Deckelbaum, Vadim S Ten
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160870 (2016)
Treatment with triglyceride emulsions of docosahexaenoic acid (tri-DHA) protected neonatal mice against hypoxia-ischemia (HI) brain injury. The mechanism of this neuroprotection remains unclear. We hypothesized that administration of tri-DHA enriches
Externí odkaz:
https://doaj.org/article/25908a8bcdaf4ecc90ae9ce63fff873f
Autor:
Sergey A Sosunov, Xavier Ameer, Zoya V Niatsetskaya, Irina Utkina-Sosunova, Veniamin I Ratner, Vadim S Ten
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120456 (2015)
This study demonstrates that in mice subjected to hypoxia-ischemia (HI) brain injury isoflurane anesthesia initiated upon reperfusion limits a release of mitochondrial oxidative radicals by inhibiting a recovery of complex-I dependent mitochondrial r
Externí odkaz:
https://doaj.org/article/432e7a840dae49aea3ffffb6dae864ae
Autor:
Hylde Zirpoli, Maria Eugenia Bernis, Hemmen Sabir, Denny Joseph Manual Kollareth, James A. Hamilton, Nasi Huang, Jesse Ng, Sergey A. Sosunov, Ben Gaebler, Vadim S. Ten, Richard J. Deckelbaum
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116749- (2024)
Hypoxic-ischemic encephalopathy (HIE), resulting from a lack of blood flow and oxygen before or during newborn delivery, is a leading cause of cerebral palsy and neurological disability in children. Therapeutic hypothermia (TH), the current standard
Externí odkaz:
https://doaj.org/article/09898beb26164f4ab55eb2a4d98f52a4
Autor:
Irina V Utkina-Sosunova, Zoya V Niatsetskaya, Sergey A Sosunov, Veniamin I Ratner, Dzmitry Matsiukevich, Vadim S Ten
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62448 (2013)
Nelfinavir (NLF), an antiretroviral agent, preserves mitochondrial membranes integrity and protects mature brain against ischemic injury in rodents. Our study demonstrates that in neonatal mice NLF significantly limits mitochondrial calcium influx, t
Externí odkaz:
https://doaj.org/article/28ca643e5f904cae9f3ba282b11cc326
Autor:
Jill J Williams, Korapat Mayurasakorn, Susan J Vannucci, Christopher Mastropietro, Nicolas G Bazan, Vadim S Ten, Richard J Deckelbaum
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56233 (2013)
We questioned if acute administration of n-3 fatty acids (FA) carried in n-3 rich triglyceride (TG) emulsions provides neuroprotection in neonatal mice subjected to hypoxic-ischemic (H/I) brain injury. We examined specificity of FA, optimal doses, an
Externí odkaz:
https://doaj.org/article/97fb6e391834423da23d251a61cdd352
Autor:
Courtney Juliano, Zoya V. Niatsetskaya, Alexander Galkin, Veniamin Ratner, Anna A. Stepanova, Sergey A. Sosunov, Vadim S. Ten
Publikováno v:
Pediatric Research. 91:1383-1390
BACKGROUND In the developing brain, the death of immature oligodendrocytes (OLs) has been proposed to explain a developmental window for vulnerability to white matter injury (WMI). However, in neonatal mice, chronic sublethal intermittent hypoxia (IH
Autor:
Hylde Zirpoli, Denny Joseph Kollareth Manual, Sergey A Sosunov, Sundas Rashid, Jesse Ng, Nasi Huang, Jaroslav Lralovec, Korapat Mayurasakorn, James A Hamilton, Vadim S Ten, Richard J Deckelbaum
Publikováno v:
Stroke. 53
Introduction: Omega-3 (n-3) fatty acids (FAs), specifically docohexaenoic acid (DHA) and eicosapentaenoic acid (EPA), act as bioactive unsaturated lipids with pleiotropic effects, affording neuroprotection in ischemic brain injury. Hypothesis: We rep
Autor:
Helu Liu, Wellington V. Cardoso, Anna Stepanova, Wei Wang, Vadim S. Ten, Jining Lu, Jessica E. Shui, Jun Qian, Grace V. Liao, Xingbin Ai
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The impact of prematurity on human development and neonatal diseases, such as bronchopulmonary dysplasia, has been widely reported. However, little is known about the effects of prematurity on the programs of stem cell self-renewal and differentiatio
Publikováno v:
Frontiers in Neurology, Vol 11 (2021)
Frontiers in Neurology
Frontiers in Neurology
Therapeutic hypothermia (HT) is a currently accepted treatment for neonatal asphyxia and is a promising strategy in adult stroke therapy. We previously reported that acute administration of docosahexaenoic acid (DHA) triglyceride emulsion (tri-DHA) p
Autor:
Sergey A, Sosunov, Zoya V, Niatsetskaya, Anna A, Stepanova, Alexander S, Galkin, Courtney E, Juliano, Veniamin I, Ratner, Vadim S, Ten
Publikováno v:
Pediatric research. 91(6)
In the developing brain, the death of immature oligodendrocytes (OLs) has been proposed to explain a developmental window for vulnerability to white matter injury (WMI). However, in neonatal mice, chronic sublethal intermittent hypoxia (IH) recapitul