Synergistic Effect of a Combination of Proteasome and Ribonucleotide Reductase Inhibitors in a Biochemical Model of the Yeast Saccharomyces cerevisiae and a Glioblastoma Cell Line

Autor: Kirill A. Kulagin, Elizaveta S. Starodubova, Pamila J. Osipova, Anastasia V. Lipatova, Igor A. Cherdantsev, Svetlana V. Poddubko, Vadim L. Karpov, Dmitry S. Karpov

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 7, p 3977 (2024)

Proteasome inhibitors are used in the therapy of several cancers, and clinical trials are underway for their use in the treatment of glioblastoma (GBM). However, GBM becomes resistant to chemotherapy relatively rapidly. Recently, the overexpression o

Externí odkaz: https://doaj.org/article/3660cfcaf8dd44ea97beab5c1ee9a7da

Complete and Prolonged Inhibition of Herpes Simplex Virus Type 1 Infection In Vitro by CRISPR/Cas9 and CRISPR/CasX Systems

Autor: Dmitry S. Karpov, Natalia A. Demidova, Kirill A. Kulagin, Anastasija I. Shuvalova, Maxim A. Kovalev, Ruslan A. Simonov, Vadim L. Karpov, Anastasiya V. Snezhkina, Anna V. Kudryavtseva, Regina R. Klimova, Alla A. Kushch

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 23, p 14847 (2022)

Almost all people become infected with herpes viruses, including herpes simplex virus type 1 (HSV-1), during their lifetime. Typically, these viruses persist in a latent form that is resistant to all available antiviral medications. Under certain con

Externí odkaz: https://doaj.org/article/093c17736d1a4ab59cd69eb592de2ca1

Biological consequences of structural and functional proteasome diversity

Autor: Alexey V. Morozov, Vadim L. Karpov

Publikováno v: Heliyon, Vol 4, Iss 10, Pp e00894- (2018)

Cell homeostasis and regulation of metabolic pathways are ensured by synthesis, proper folding and efficient degradation of a vast amount of proteins. Ubiquitin-proteasome system (UPS) degrades most intracellular proteins and thus, participates in re

Externí odkaz: https://doaj.org/article/eb8aa340f83d4a31b72a39558de0a91a

Immunoproteasome Inhibitor ONX-0914 Affects Long-Term Potentiation in Murine Hippocampus

Autor: Vera V. Tutyaeva, Daria S. Spasskaya, Natalia V. Bal, Alexander V. Maltsev, A. V. Morozov, Sergei Funikov, Tatjana Astakhova, A. V. Deikin, Vadim L. Karpov, Vasilina Ignatyuk, Yulia V. Lyupina, Alexander Burov

Publikováno v: Journal of Neuroimmune Pharmacology. 16:7-11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42951791a077f03aaf10fe89f73431f7
https://doi.org/10.1007/s11481-020-09973-0

Rpn4 and proteasome-mediated yeast resistance to ethanol includes regulation of autophagy

Autor: Frank Kjeldsen, Dmitry S. Karpov, Mikhail V. Gorshkov, Irina A. Tarasova, Daria S. Spasskaya, Aleksandra M. Kofanova, Julia A. Bubis, Vladimir Gorshkov, Vadim L. Karpov, Dmitry S. Lekanov

Publikováno v: Applied Microbiology and Biotechnology
Bubis, J A, Spasskaya, D S, Gorshkov, V A, Kjeldsen, F, Kofanova, A M, Lekanov, D S, Gorshkov, M V, Karpov, V L, Tarasova, I A & Karpov, D S 2020, ' Rpn4 and proteasome-mediated yeast resistance to ethanol includes regulation of autophagy ', Applied Microbiology and Biotechnology, vol. 104, no. 9, pp. 4027-4041 . https://doi.org/10.1007/s00253-020-10518-x

Distilled spirits production using Saccharomyces cerevisiae requires understanding of the mechanisms of yeast cell response to alcohol stress. Reportedly, specific mutations in genes of the ubiquitin-proteasome system, e.g., RPN4, may result in strai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc9d77c126636aee8dde342732b1ead
https://doi.org/10.1007/s00253-020-10518-x