Výsledky vyhledávání

Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation

Autor: Lei Fang, Becky Adkins, Eckhard R. Podack, Vadim Deyev

Publikováno v: The Journal of Experimental Medicine

We identify the tumor necrosis factor receptor superfamily 25 (TNFRSF25)/TNFSF15 pair as critical trigger for allergic lung inflammation, which is a cardinal feature of asthma. TNFRSF25 (TNFR25) signals are required to exert T helper cell 2 (Th2) eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4714db6a02df92a30ff12d65773f23
https://doi.org/10.1084/jem.20072528

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Molecular and Cellular Requirements for Enhanced Antigen Cross-Presentation to CD8 Cytotoxic T Lymphocytes

Autor: Satoshi Oizumi, Savita Pahwa, Natasa Strbo, Vadim Deyev, Eckhard R. Podack

Publikováno v: The Journal of Immunology. 179:2310-2317

MHC class I-mediated cross-priming of CD8 T cells by APCs is critical for CTL-based immunity to viral infections and tumors. We have shown previously that tumor-secreted heat shock protein gp96-chaperoned peptides cross prime CD8 CTL that are specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99db88a5bb10f3f21c16e797816931aa
https://doi.org/10.4049/jimmunol.179.4.2310

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Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-κB

Autor: Nicole C. Shank, Subrata K. Ghosh, Abdul M. Mian, Vadim Deyev, Ngoc L. Toomey, Lawrence H. Boise, William J. Harrington, Glen N. Barber, Gerold Feuer, Lisa Cabral, Charles E. Wood

Publikováno v: Blood. 101:2321-2327

The survival of viral mediated lymphomas depends upon constitutive nuclear factor kappa B (NF-kappaB) activity. AIDS-related human herpesvirus type 8-associated primary effusion lymphoma (PEL) responds poorly to chemotherapy and is almost invariably

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fe8ffcac15c52e3b7012519304917c
https://doi.org/10.1182/blood-2002-08-2525

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Induction of a TRAIL mediated suicide program by interferon alpha in primary effusion lymphoma

Autor: Duncan Scott, William J. Harrington, Lisa Cabral, Glen N. Barber, Charles E. Wood, Lawrence H. Boise, Lei Hua Liu, Vadim Deyev, Eckhard R. Podack, Ngoc L. Toomey

Publikováno v: Oncogene. 20:7029-7040

Gammaherpes viruses are often detected in lymphomas arising in immunocompromised patients. We have found that Azidothymidine (AZT) alone induces apoptosis in Epstein Barr Virus (EBV) positive Burkitt's lymphoma (BL) cells but requires interferon alph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad1fb333ce2803791062ce42f050519
https://doi.org/10.1038/sj.onc.1204895

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Cloning, expression, and functional characterization of TL1A-Ig

Autor: Matthew S. Tsai, Vadim Deyev, Eckhard R. Podack, Dietlinde Wolf, Samia Q. Khan, Taylor H. Schreiber

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 190(4)

TNF superfamily member 15 (TL1A) is the ligand for TNFR superfamily (TNFRSF)25. We previously reported that TNFRSF25 stimulation with an agonist Ab, 4C12, expands pre-existing CD4+Foxp3+ regulatory T cells (Tregs) in vivo. To determine how the physio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63794321e558f9c09889f45a533d31d
https://pubmed.ncbi.nlm.nih.gov/23319737

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Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

Autor: Taylor H. Schreiber, Eckhard R. Podack, Thomas R. Malek, Vadim Deyev, Dietlinde Wolf, Jackie Chirinos, Louis Gonzalez, Robert B. Levy, Matthew S. Tsai

TNF receptor superfamily member 25 (TNFRSF25; also known as DR3, and referred to herein as TNFR25) is constitutively and highly expressed by CD4+FoxP3+ Tregs. However, its function on these cells has not been determined. Here we used a TNFR25-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96300c6ab16b77939955b8b2c517b8c9
https://europepmc.org/articles/PMC2947231/

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Tumor induced suppression of CTL expansion and subjugation by gp96-Ig vaccination

Autor: Taylor H. Schreiber, Joseph D. Rosenblatt, Vadim Deyev, Eckhard R. Podack

Established tumors suppress antitumor immune responses and induce tolerance by incompletely characterized mechanisms, and this phenomenon is an important barrier to tumor immunotherapy. Single vaccination with tumor cells expressing gp96-Ig stimulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2a704c8043ea1fc8345a9fcf94e3d3
https://europepmc.org/articles/PMC2676230/

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