Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Vadim Budagian"'
Autor:
René Rückert, Vadim Budagian, Silvia Bulfone-Paus, Claudia Metzler, Elena Csernok, Kathleen Marienfeld, Ralf Paus, Martin Ernst, Katja Brandt, Elena Bulanova
Publikováno v:
Immunology. 126:63-73
Interleukin-15 (IL-15) is a proinflammatory cytokine that is overexpressed in rheumatoid arthritis (RA), a disease characterized by activation of monocytes/macrophages (MPhi), and by expansion of autoreactive CD4(+) T cells. We hypothesized that IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13db7bd0d91b55d030c9fa4f4398baf6
https://doi.org/10.1111/j.1365-2567.2008.02878.x
https://doi.org/10.1111/j.1365-2567.2008.02878.x
Autor:
Erwin Hans Duitman, Silvia Bulfone-Paus, Vadim Budagian, Hans Krause, Norbert Reiling, René Rückert, Zane Orinska, Elena Bulanova
Publikováno v:
Journal of Biological Chemistry. 282:13167-13179
Interleukin 15 (IL-15) is a pleiotropic cytokine that is hardly detectable in biological fluids. Here, we show that IL-15 forms functional heterocomplexes with soluble high affinity IL-15 receptor alpha (IL-15Ralpha) chain in mouse serum and cell-con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8202f4dc44e1490fccd82d1172d7c4a
https://doi.org/10.1074/jbc.m610036200
https://doi.org/10.1074/jbc.m610036200
Publikováno v:
The Journal of Immunology. 170:5045-5055
Mast cells previously have been reported to be regulated by IL-15 and to express a distinct IL-15R, termed IL-15RX. To further examine IL-15 binding and signaling in mast cells, we have studied the nature of the IL-15R and some of its biological acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debe0a2be713103834eed64ac3de9236
https://doi.org/10.4049/jimmunol.170.10.5045
https://doi.org/10.4049/jimmunol.170.10.5045
Autor:
Vadim Budagian, Zane Orinska, Jürgen Löhler, Elena Bulanova, Silvia Bulfone-Paus, Ivan Horak, Anna Osiak
Publikováno v:
European Journal of Immunology. 32:3472-3480
Surface expression of IgM is a characteristic feature of the development of most B cells. Only pre-B cells bearing functional IgM heavy chains mu chains) are selected for clonal expansion and differentiation. Cells lacking mu chains are normally elim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9fd6488f211c328c88d1b2031950ba
https://doi.org/10.1002/1521-4141(200212)32:12<3472::aid-immu3472>3.0.co
https://doi.org/10.1002/1521-4141(200212)32:12<3472::aid-immu3472>3.0.co
Autor:
René Rückert, Silvia Bulfone-Paus, Khusru Asadullah, Claudia Trombotto, Vadim Budagian, Ralf Arnold, Ralf Paus, Martina Seifert
Publikováno v:
The Journal of Immunology. 165:2240-2250
Keratinocytes (KC) are important source of and targets for several cytokines. Although KC express IL-15 mRNA, the functional effects of IL-15 on these epithelial cells remain to be dissected. Investigating primary human foreskin KC and HaCaT cells, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da60ae789a9fe70b69bb294544825157
https://doi.org/10.4049/jimmunol.165.4.2240
https://doi.org/10.4049/jimmunol.165.4.2240
Autor:
Vadim Budagian, Robert H. Silverman, Silvia Bulfone-Paus, Zane Orinska, Elena Bulanova, Thomas Pohl, Ernest C. Borden
The results from this study implicate membrane-anchored interleukin (IL)-15 constitutively expressed on the cell surface of PC-3 human prostate carcinoma cells and interferon-gamma-activated human monocytes in reverse signaling upon stimulation with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f299b7a143440e36582a74f5cb4c6a1f
https://europepmc.org/articles/PMC3048753/
https://europepmc.org/articles/PMC3048753/
Autor:
Erwin Hans Duitman, Paul Saftig, Zane Orinska, Greg Lemke, Katja Brandt, Vadim Budagian, Elena Bulanova, Silvia Bulfone-Paus, Andreas Ludwig, Dieter Hartmann
Axl receptor tyrosine kinase exists as a transmembrane protein and as a soluble molecule. We show that constitutive and phorbol 12-myristate 13-acetate-induced generation of soluble Axl (sAxl) involves the activity of disintegrin-like metalloproteina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be1798b76385ac301d56fec5c7562cd
https://europepmc.org/articles/PMC3067907/
https://europepmc.org/articles/PMC3067907/
Autor:
Silvia Bulfone-Paus, Zane Orinska, Friedrich Haag, Vadim Budagian, Elena Bulanova, Friedrich Koch-Nolte
Publikováno v:
Journal of leukocyte biology. 85(4)
Extracellular ATP mediates a diverse array of biological responses in many cell types and tissues, including immune cells. We have demonstrated that ATP induces purinergic receptor P2X(7) mediated membrane permeabilization, apoptosis, and cytokine ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d221b0146b258ea7b137a161553e4bed
https://pubmed.ncbi.nlm.nih.gov/21357248
https://pubmed.ncbi.nlm.nih.gov/21357248
Autor:
Elena Bulanova, Florian Schiemann, Silvia Bulfone-Paus, Natalia Nashkevich, Martin Metz, Ernst Brandt, Ralf Paus, Jan Schulmistrat, Julien Giron-Michel, Zane Orinska, Marcus Maurer, Farhad Mirghomizadeh, Vadim Budagian
Publikováno v:
Nature medicine. 13(8)
Sepsis remains a global clinical problem. By using the mouse cecal ligation and puncture model of sepsis, here we identify an important aspect of mast cell (MC)-dependent, innate immune defenses against Gram-negative bacteria by demonstrating that MC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f81b0adc8994b2e1f3d32018e22ba0a
https://pubmed.ncbi.nlm.nih.gov/17680000
https://pubmed.ncbi.nlm.nih.gov/17680000
Publikováno v:
Cytokinegrowth factor reviews. 17(4)
The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e1869078d9bf159c3f78debc0e8426
https://pubmed.ncbi.nlm.nih.gov/16815076
https://pubmed.ncbi.nlm.nih.gov/16815076