Zobrazeno 1 - 10
of 512
pro vyhledávání: '"Vadim Backman"'
Autor:
Aayush Kant, Zixian Guo, Vinayak Vinayak, Maria Victoria Neguembor, Wing Shun Li, Vasundhara Agrawal, Emily Pujadas, Luay Almassalha, Vadim Backman, Melike Lakadamyali, Maria Pia Cosma, Vivek B. Shenoy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract In interphase nuclei, chromatin forms dense domains of characteristic sizes, but the influence of transcription and histone modifications on domain size is not understood. We present a theoretical model exploring this relationship, consideri
Externí odkaz:
https://doaj.org/article/7ba9d1e5bc1d47f38d36e5b6b9d90cfc
Autor:
Marcelo A Carignano, Martin Kroeger, Luay M Almassalha, Vasundhara Agrawal, Wing Shun Li, Emily M Pujadas-Liwag, Rikkert J Nap, Vadim Backman, Igal Szleifer
Publikováno v:
eLife, Vol 13 (2024)
We propose the Self Returning Excluded Volume (SR-EV) model for the structure of chromatin based on stochastic rules and physical interactions. The SR-EV rules of return generate conformationally defined domains observed by single-cell imaging techni
Externí odkaz:
https://doaj.org/article/ada327e7a2574fb0a160078acbfe74fc
Autor:
Andrew Chang, Sravya Prabhala, Ali Daneshkhah, Jianan Lin, Hariharan Subramanian, Hemant Kumar Roy, Vadim Backman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low (~ 7 to 8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to identify patients who harbor CRC field carcinogenesis by
Externí odkaz:
https://doaj.org/article/42860204b9af41e0bf13ac1109134cdb
Autor:
Emily M. Pujadas Liwag, Xiaolong Wei, Nicolas Acosta, Lucas M. Carter, Jiekun Yang, Luay M. Almassalha, Surbhi Jain, Ali Daneshkhah, Suhas S. P. Rao, Fidan Seker-Polat, Kyle L. MacQuarrie, Joe Ibarra, Vasundhara Agrawal, Erez Lieberman Aiden, Masato T. Kanemaki, Vadim Backman, Mazhar Adli
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-42 (2024)
Abstract Background B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture. However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joi
Externí odkaz:
https://doaj.org/article/4305f5fcf633415aacff6d99aeabee41
Autor:
Flavio R. Palma, Diego R. Coelho, Kirthi Pulakanti, Marcelo J. Sakiyama, Yunping Huang, Fernando T. Ogata, Jeanne M. Danes, Alison Meyer, Cristina M. Furdui, Douglas R. Spitz, Ana P. Gomes, Benjamin N. Gantner, Sridhar Rao, Vadim Backman, Marcelo G. Bonini
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114415- (2024)
Externí odkaz:
https://doaj.org/article/425e2d4d57dd43c7b3fb3e7ae2f1fbd1
Autor:
Ali Daneshkhah, Sravya Prabhala, Parvathi Viswanathan, Hariharan Subramanian, Jianan Lin, Andrew S Chang, Ankit Bharat, Hemant Kumar Roy, Vadim Backman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Supranucleosomal chromatin structure, including chromatin domain conformation, is involved in the regulation of gene expression and its dysregulation has been associated with carcinogenesis. Prior studies have shown that cells in the buccal
Externí odkaz:
https://doaj.org/article/15ecb9fa213d4cdcaba6bc61a8c144db
Autor:
Anne R Shim, Jane Frederick, Emily M Pujadas, Tiffany Kuo, I Chae Ye, Joshua A Pritchard, Cody L Dunton, Paola Carrillo Gonzalez, Nicolas Acosta, Surbhi Jain, Nicholas M Anthony, Luay M Almassalha, Igal Szleifer, Vadim Backman
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0301000 (2024)
As imaging techniques rapidly evolve to probe nanoscale genome organization at higher resolution, it is critical to consider how the reagents and procedures involved in sample preparation affect chromatin at the relevant length scales. Here, we inves
Externí odkaz:
https://doaj.org/article/89f2c803491e4e51a3af9fa3dee2c896
Autor:
Joe Ibarra, Tyler Hershenhouse, Luay Almassalha, David Walterhouse, Vadim Backman, Kyle L. MacQuarrie
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Myogenesis, the progression of proliferating skeletal myoblasts to terminally differentiated myotubes, regulates thousands of target genes. Uninterrupted linear arrays of such genes are differentially associated with specific chromosomes, suggesting
Externí odkaz:
https://doaj.org/article/dc8fbc09584b4c42a266dc32c5d86b4d
Autor:
Siona Prasad, Alex Rankine, Tarun Prasad, Patrick Song, Maxim E. Dokukin, Nadezda Makarova, Vadim Backman, Igor Sokolov
Publikováno v:
Advanced NanoBiomed Research, Vol 3, Iss 5, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/3b8befc69010463bad45d58eb6691e76
Autor:
Yue Li, Vasundhara Agrawal, Ranya K. A. Virk, Eric Roth, Wing Shun Li, Adam Eshein, Jane Frederick, Kai Huang, Luay Almassalha, Reiner Bleher, Marcelo A. Carignano, Igal Szleifer, Vinayak P. Dravid, Vadim Backman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Chromatin organization over multiple length scales plays a critical role in the regulation of transcription. Deciphering the interplay of these processes requires high-resolution, three-dimensional, quantitative imaging of chromatin structur
Externí odkaz:
https://doaj.org/article/95e9bc0d9d7640c08306f1bc5e567e6e