Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Vadim Alexandrov"'
Publikováno v:
PeerJ, Vol 10, p e14252 (2022)
Background This work presents a novel computational multi-reference poly-conformational algorithm for design, optimization, and repositioning of pharmaceutical compounds. Methods The algorithm searches for candidates by comparing similarities between
Externí odkaz:
https://doaj.org/article/8255b83fdaa04162be81a58aa945a4e9
Autor:
Daniela Brunner, Patricia Kabitzke, Dansha He, Kimberly Cox, Lucinda Thiede, Taleen Hanania, Emily Sabath, Vadim Alexandrov, Michael Saxe, Elior Peles, Alea Mills, Will Spooren, Anirvan Ghosh, Pamela Feliciano, Marta Benedetti, Alice Luo Clayton, Barbara Biemans
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134572 (2015)
Autism spectrum disorder comprises several neurodevelopmental conditions presenting symptoms in social communication and restricted, repetitive behaviors. A major roadblock for drug development for autism is the lack of robust behavioral signatures p
Externí odkaz:
https://doaj.org/article/e35f4f77165f456ea1e7df729198b9bf
Autor:
Jesse E Hanson, Hank La, Emile Plise, Yung-Hsiang Chen, Xiao Ding, Taleen Hanania, Emily V Sabath, Vadim Alexandrov, Dani Brunner, Emer Leahy, Pascal Steiner, Lichuan Liu, Kimberly Scearce-Levie, Qiang Zhou
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69964 (2013)
Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) used for the treatment of cutaneous T cell lymphoma (CTCL) and under consideration for other indications. In vivo studies suggest reducing HDAC function can enhanc
Externí odkaz:
https://doaj.org/article/addf2a25361642e3b585a1287e45a910
Autor:
Valery R. Polyakov, Vadim Alexandrov, Andreas Maderna, Krishna Bajjuri, Xiaofan Li, Sihong Zhou
Publikováno v:
Journal of Chemical Information and Modeling. 62:2446-2455
A method is presented for an ultrafast shape-based search workflow for the screening of large compound collections, i.e., those of vendors. The three-dimensional shape of a molecule dictates its biological activity by enabling the molecule to fit int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c632abd6a62c7ddbc0c1e172ac7847
https://doi.org/10.1021/acs.jcim.2c00156
https://doi.org/10.1021/acs.jcim.2c00156
Autor:
Raoul Nigmatullin, Vadim Alexandrov, Artem Sidelnikov, Herman Budnikov, Elza Maksyutova, Adel Kvyatkovskaya
Publikováno v:
New Journal of Chemistry. 46:12148-12157
In this paper, ideal boundary conditions have been created for recording instrument noises and their fluctuations at the level of pico-currents to identify the best “ideal” device using voltammetric time series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b864004a5fd9c6e779776bacb25d06a
https://doi.org/10.1039/d2nj01436j
https://doi.org/10.1039/d2nj01436j
Autor:
Vadim Alexandrov, Maria Vilenchik, Omar Kantidze, Nika Tsutskiridze, Daviti Kharchilava, Pema Lhewa, Aleksandr Shishkin, Yuriy Gankin, Alexander Kirpich
Publikováno v:
Journal of medicinal chemistry. 65(20)
In addition to general challenges in drug discovery such as the identification of lead compounds in time- and cost-effective ways, specific challenges also exist. Particularly, it is necessary to develop pharmacological inhibitors that effectively di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eedf743234e3bd6562e9f2541da647
https://pubmed.ncbi.nlm.nih.gov/36239428
https://pubmed.ncbi.nlm.nih.gov/36239428
Autor:
Vadim Alexandrov, Ilya Rezkov
Publikováno v:
2022 16th International Conference on Stability and Oscillations of Nonlinear Control Systems (Pyatnitskiy's Conference).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5690e54061ef293ee443e98511523e1a
https://doi.org/10.1109/stab54858.2022.9807529
https://doi.org/10.1109/stab54858.2022.9807529
In this work a novel computational multi-reference poly-conformational algorithm is presented for design, optimization, and repositioning of pharmaceutical compounds. The algorithm searches for candidates by comparing similarities between conformers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb1e0c29f1ea723a0eb114666f910878
https://doi.org/10.21203/rs.3.rs-153954/v2
https://doi.org/10.21203/rs.3.rs-153954/v2
Autor:
Abubakari Ibn Sidiki, Aliu Moomin, Alexandr Nikolaevich Lishchuk, Maridia Kunateh Adam, Malik Kiaed Al-Ariki, Vadim Alexandrovich Ananko, Linus Baatiema, Nomo Richard Angmortey, Paa Kofi Tawiah Adu-Gyamfi, Kwesi Boadu Mensah
Publikováno v:
Journal of Water and Health, Vol 22, Iss 5, Pp 896-904 (2024)
Hand hygiene (HH) is the most effective way to curb the spread of healthcare-associated infections. Nonetheless, healthcare personnel encounter difficulties in adhering to WHO HH recommendations. This study aimed to investigate HH compliance and adhe
Externí odkaz:
https://doaj.org/article/7c9f0cac5d65474b8ab9bd978733d399
The COVID-19 epidemic, SARS-CoV-2, that began in December of 2019 has drastically altered the aspects of daily life across the global society. Time-effective treatment of those infected has since become a major goal with multiple treatment strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18a19a9b3885983c8f1f0ffa18f17af
https://doi.org/10.21203/rs.3.rs-153954/v1
https://doi.org/10.21203/rs.3.rs-153954/v1