Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Vaddadi N. Vyjayanti"'
Autor:
Dorjbal Dorjsuren, Daemyung Kim, Vaddadi N Vyjayanti, David J Maloney, Ajit Jadhav, David M Wilson, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47974 (2012)
The major human apurinic/apyrimidinic endonuclease APE1 plays a pivotal role in the repair of base damage via participation in the DNA base excision repair (BER) pathway. Increased activity of APE1, often observed in tumor cells, is thought to contri
Externí odkaz:
https://doaj.org/article/7dd48e00bf4e4e138168f8756a99b456
Autor:
Daniel R. McNeill, Vaddadi N. Vyjayanti, Manikandan Paramasivam, Jing Huang, David M. Wilson, Michael M. Seidman, Jakita Baldwin
Publikováno v:
The Journal of biological chemistry, vol 288, iss 18
Recent evidence suggests a role for base excision repair (BER) proteins in the response to DNA interstrand crosslinks, which block replication and transcription, and lead to cell death and genetic instability. Employing fluorescently tagged fusion pr
Autor:
Dorjbal Dorjsuren, Vaddadi N. Vyjayanti, David J. Maloney, Ganesha Rai, David M. Wilson, Ajit Jadhav, Anton Simeonov
APE1 is an essential protein that operates in the base excision repair (BER) pathway and is responsible for ≥95% of the total apurinic/apyrimidinic (AP) endonuclease activity in human cells. BER is a major pathway that copes with DNA damage induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0076af830436e03403a256bc664694
https://europepmc.org/articles/PMC3515842/
https://europepmc.org/articles/PMC3515842/
Autor:
Anton Simeonov, Daemyung Kim, Vaddadi N. Vyjayanti, David J. Maloney, David M. Wilson, Ajit Jadhav, Dorjbal Dorjsuren
Publikováno v:
PloS one, vol 7, iss 10
PLoS ONE, Vol 7, Iss 10, p e47974 (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e47974 (2012)
PLoS ONE
The major human apurinic/apyrimidinic endonuclease APE1 plays a pivotal role in the repair of base damage via participation in the DNA base excision repair (BER) pathway. Increased activity of APE1, often observed in tumor cells, is thought to contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f2553b9cadf239ec4a517213572f08
https://escholarship.org/uc/item/3cv3z2wq
https://escholarship.org/uc/item/3cv3z2wq
Autor:
Lodewijk V. Dekker, Mohammed Z. Mohammed, Vaddadi N. Vyjayanti, Rachel Abbotts, Suharsh Shah, Poulam M. Patel, Charles A. Laughton, Ian D. Hickson, Srinivasan Madhusudan, Peter Fischer, David M. Wilson
Publikováno v:
British journal of cancer, vol 104, iss 4
British Journal of Cancer
British Journal of Cancer
Aims: Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma and glioma. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fa30528723119271fc0164bb2552cc
https://escholarship.org/uc/item/3x4556b6
https://escholarship.org/uc/item/3x4556b6
Autor:
Charles A. Laughton, Vaddadi N. Vyjayanti, Mohammed Z. Mohammed, Lodewijk V. Dekker, Peter Fischer, David M. Wilson, Srinivasan Madhusudan
Publikováno v:
Cancer Research. 70:687-687
Potentially cytotoxic AP site is an obligatory intermediate in base excision repair that is repaired by APE1. In the previous study we used fluorescence-based high through-put screening of a chemical library, biochemical and cellular investigations t