Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Vadappuram P. Chacko"'
Autor:
Ashish Gupta, Cory Rohlfsen, Michelle K Leppo, Vadappuram P Chacko, Yibin Wang, Charles Steenbergen, Robert G Weiss
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e74675 (2013)
Doxorubicin (DOX) is a commonly used life-saving antineoplastic agent that also causes dose-dependent cardiotoxicity. Because ATP is absolutely required to sustain normal cardiac contractile function and because impaired ATP synthesis through creatin
Externí odkaz:
https://doaj.org/article/b36be0f345094d0ca6f3aa0bdeac476f
Calcium Metabolism in Enzymatically Dissociated Rat Heart Cells and in Intact Perfused Ferret Hearts
Autor:
Vadappuram P. Chacko, W. Gil Wier, Eduardo Marbán, Martin M. Pike, Masafumi Kitakaze, David T. Yue, Shawn W. Robinson
Publikováno v:
Analysis and Simulation of the Cardiac System — Ischemia ISBN: 9781003068341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ce5f2548df68074e6490305def341c
https://doi.org/10.1201/9781003068341-36
https://doi.org/10.1201/9781003068341-36
Autor:
Toshiyuki Yano, Michelle K. Leppo, Ashish Gupta, Ashwin Akki, Jason Su, Charles Steenbergen, Vadappuram P. Chacko, Yibin Wang, Robert G. Weiss
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 303:H844-H852
Reduced myofibrillar ATP availability during prolonged myocardial ischemia may limit post-ischemic mechanical function. Because creatine kinase (CK) is the prime energy reserve reaction of the heart and because it has been difficult to augment ATP sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc0de3dcc349294bfa4461cf325c77c
https://doi.org/10.1152/ajpheart.00268.2012
https://doi.org/10.1152/ajpheart.00268.2012
Autor:
Jason Su, Viviane Caceres, Vadappuram P. Chacko, Ashwin Akki, Michelle K. Leppo, Gary Gerstenblith, Robert G. Weiss, D. Brian Foster, Yibin Wang, Ashish Gupta, Sa Shi, Nazareno Paolocci, Jonathan A. Kirk, Charles Steenbergen, Shenghan Lai
Publikováno v:
Journal of Clinical Investigation. 122:291-302
ATP is required for normal cardiac contractile function, and it has long been hypothesized that reduced energy delivery contributes to the contractile dysfunction of heart failure (HF). Despite experimental and clinical HF data showing reduced metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5365a2cb8f9fd00c4951069ff857310
https://doi.org/10.1172/jci57426
https://doi.org/10.1172/jci57426
Autor:
Partha Hota, Vadappuram P. Chacko, Dara L. Kraitchman, Ronald Ouwerkerk, Jesús Ruiz-Cabello, Wesley D. Gilson, Piotr Walczak, Cal Lauzon, Jeff W.M. Bulte, Brad P. Barnett, Michael J. Shamblott, Aravind Arepally
Publikováno v:
Contrast Media & Molecular Imaging. 6:251-259
In vivo imaging of engraftment and immunorejection of transplanted islets is critical for further clinical development, with (1)H MR imaging of superparamagnetic iron oxide-labeled cells being the current premier modality. Using perfluorocarbon nanop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43f9af2685faa950bd1da9d09813e5da
https://doi.org/10.1002/cmmi.424
https://doi.org/10.1002/cmmi.424
Autor:
Jesús Ruiz-Cabello, Jeff W.M. Bulte, Valerie Howland, Partha Hota, Dara L. Kraitchman, Vadappuram P. Chacko, Brad P. Barnett, Piotr Walczak, Robert P. Liddell, Aravind Arepally
Publikováno v:
Radiology. 258:182-191
Fluorocapsules provide simultaneous immunoprotection, enhancement of survival, and multimodality imaging of cellular therapeutics by using fluorine 19 MR, US, or CT imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7636a9058d30c45af776e60d482edb6e
https://doi.org/10.1148/radiol.10092339
https://doi.org/10.1148/radiol.10092339
Publikováno v:
Circulation: Cardiovascular Imaging. 4:42-50
Background— The hypothesis that the failing heart may be energy-starved is supported in part by observations of reduced rates of adenosine 5′-triphosphate (ATP) synthesis through the creatine kinase (CK) reaction, the primary myocardial energy re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd053b2a837c008d6e01164e2c002fe
https://doi.org/10.1161/circimaging.110.959320
https://doi.org/10.1161/circimaging.110.959320
High-Resolution Ultrasound in Research of Mouse Orthotopic Glioma and Ultrasound-Guided Cell Implant
Autor:
MingDe Lin, Vadappuram P. Chacko, Manon Buijs, Mustafa Vali, Jean Francois H. Geschwind, Labiq H. Syed, Shinichi Ota, Eleni Liapi, Rani Kunjithapatham, Byung Kook Kwak, Romaric Loffroy, Shanmugasundaram Ganapathy-Kanniappan, Pramod Rao
Publikováno v:
Advances in Molecular Imaging. :24-32
The purpose is to evaluate the feasibility of imaging mouse brain with high resolution ultrasound (HiRes US), and generation of mouse brain tumor (glioma) model under HiRes US guided implantation of glioma cells. Normal mouse brain was imaged with 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0833b08382dff043b76ff69bed9ab2c7
https://doi.org/10.4236/ami.2011.12004
https://doi.org/10.4236/ami.2011.12004
Autor:
Ashwin Akki, Mikhail Y. Maslov, Vadappuram P. Chacko, Glenn A. Hirsch, Michelle K. Leppo, Robert G. Weiss, Charles Steenbergen
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 299:H332-H337
Adriamycin (ADR) is an established, life-saving antineoplastic agent, the use of which is often limited by cardiotoxicity. ADR-induced cardiomyopathy is often accompanied by depressed myocardial high-energy phosphate (HEP) metabolism. Impaired HEP me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a479ee0fbb65278339c477e294b978a
https://doi.org/10.1152/ajpheart.00727.2009
https://doi.org/10.1152/ajpheart.00727.2009
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 297:H59-H64
31P magnetic resonance spectroscopy (MRS) offers a unique means to noninvasively quantify the major cardiac high-energy phosphates, creatine phosphate (PCr) and adenosine 5′-triphosphate (ATP), that are critical for normal myocardial contractile fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0587f53b8864a57243e78e8fb67173
https://doi.org/10.1152/ajpheart.00178.2009
https://doi.org/10.1152/ajpheart.00178.2009