Zobrazeno 1 - 10
of 2 507
pro vyhledávání: '"Vaccine design"'
Autor:
Huiming Xia, My H. Hoang, Evelyn Schmidt, Susanna Kiwala, Joshua McMichael, Zachary L. Skidmore, Bryan Fisk, Jonathan J. Song, Jasreet Hundal, Thomas Mooney, Jason R. Walker, S. Peter Goedegebuure, Christopher A. Miller, William E. Gillanders, Obi L. Griffith, Malachi Griffith
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Neoantigen-targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving these th
Externí odkaz:
https://doaj.org/article/01d72c65e37e4a128cc544c775252cbb
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3348-3357 (2024)
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) have been a critical threat to swine health since 1987 due to its high mutation rate and substantial economic loss over half a billion dollar in USA. The rapid mutation rate of PRRSV present
Externí odkaz:
https://doaj.org/article/c2846c4ba8fe4413ba51c6cefda8f360
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 8, Pp 359-368 (2024)
Objective: To prepare and characterize polycaprolactone (PCL) nanoparticles loaded with sonicator fragmented (SLA) and freeze- thaw Leishmania antigens (FTLA) and to investigate the in vitro immunogenicity of antigen-encapsulated nanoparticles with c
Externí odkaz:
https://doaj.org/article/df39408a42744c9da1ceb2643a4feac2
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract T and B cell activation are equally important in triggering and orchestrating adaptive host responses to design multi-epitope African swine fever virus (ASFV) vaccines. However, few design methods have considered the trade-off between T and
Externí odkaz:
https://doaj.org/article/6769b9acb34243d7909fef6757011ca8
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Canine distemper virus (CDV) affects many domestic and wild animals. Variations among CDV genome linages could lead to vaccination failure. To date, there are several vaccine alternatives, such as a modified live virus and a recombinant vacc
Externí odkaz:
https://doaj.org/article/02e6fd013c6f42ee999fa4111c110d20
Autor:
Ansaya Pumchan, Porranee Proespraiwong, Orathai Sawatdichaikul, Thararat Phurahong, Ikuo Hirono, Sasimanas Unajak
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Regarding several infectious diseases in fish, multiple vaccinations are not favorable. The chimeric multiepitope vaccine (CMEV) harboring several antigens for multi-disease prevention would enhance vaccine efficiency in terms of multiple di
Externí odkaz:
https://doaj.org/article/274a70a123914d0f9ebbe818b017fdcd
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Advances in immunotherapy rely on targeting novel cell surface antigens, including therapeutically relevant peptide fragments presented by HLA molecules, collectively known as the actionable immunopeptidome. Although the immunopeptidome of classical
Externí odkaz:
https://doaj.org/article/090e791c54054dbc944f7ada9d0c5727
Publikováno v:
Aquaculture and Fisheries, Vol 9, Iss 2, Pp 105-114 (2024)
The defense system of teleost fish organized on innate and adaptive immunity protects them against a wide variety of pathogenic microorganisms in the aquatic environment. Phagocytosis is one of the most effective defense strategies against microbial
Externí odkaz:
https://doaj.org/article/66fd2c819a154ca48d8dbf334da63a0c
Autor:
Yuezhi Lin, Yayu Wang, Hongxin Li, Tong Liu, Jiaqi Zhang, Xing Guo, Wei Guo, Yaoxin Wang, Xiangning Liu, Shaoli Huang, Huaxin Liao, XiaoJun Wang
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Single B cells-based antibody platforms offer an effective approach for the discovery of useful antibodies for therapeutic or research purposes. Here we present a method for screening equine immunoglobins F(ab)2, which offers the potential advantage
Externí odkaz:
https://doaj.org/article/d71b4793a11f455899ed2e133b552a3b
Autor:
Elijah K. Oladipo, Olanrewaju D. Oyelakin, Abdulsamad O. Aiyelabegan, Elizabeth O. Olajide, Victoria O. Olatayo, Kaothar P. Owolabi, Yewande B. Shittu, Rhoda O. Olugbodi, Hezekiah A. Ajala, Raji A. Rukayat, Deborah O. Olayiwola, Boluwatife A. Irewolede, Esther M. Jimah, Julius K. Oloke, Taiwo O. Ojo, Olumide F. Ajani, Bamidele A. Iwalokun, Olatunji M. Kolawole, Olumuyiwa E. Ariyo, Daniel A. Adediran, Seun E. Olufemi, Helen Onyeaka
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 8, Pp n/a-n/a (2024)
Abstract Background Messenger RNA (mRNA) vaccines emerged as a powerful tool in the fight against infections. Unlike traditional vaccines, this unique type of vaccine elicits robust and persistent innate and humoral immune response with a unique host
Externí odkaz:
https://doaj.org/article/88dfbc68d20b4826a2c822ea7e86bd91