Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study

Autor: van der Valk, MJM, Hilling, DE, Bastiaannet, E, Meershoek-Klein Kranenbarg, E, Beets, GL, Figueiredo, NL, Habr-Gama, A, Perez, RO, Renehan, AG, van de Velde, CJH, IWWD Consortium, Ahlberg, M, Appelt, A, Asoglu, O, Bär, M-T, Barroca, R, Beets-Tan, RGH, Belgers, EHJ, Bosker, RJI, Breukink, SO, Bujko, K, Carvalho, C, Cunningham, C, Creavin, B, D'Hoore, A, Gérard, J-P, Gollins, S, Hoff, C, Holman, FA, Hupkens, BJP, Iseas, S, Jakobsen, A, Keshvari, A, Koopal, SA, Kusters, M, Langheinrich, M, Leijtens, JWA, Maas, M, Malcomson, L, Mamedli, ZZ, Martling, A, Matzel, KE, Melenhorst, J, Morici, ML, Murad-Regadas, SM, O'Dwyer, ST, Peeters, KCMJ, Rosa, I, Rossi, G, Rutten, HJT, Sanchez Loria, F, van der Sande, ME, São Julião, GP, Saunders, M, Sun Myint, A, van der Sluis, H, Schiappa, R, Scott, N, Stoot, JHMB, Talsma, AK, Terrasson, I, Tokmak, H, Vaccaro, CA, Vahrmeijer, AL, Wasowicz, DK, Westreenen, HL, Winter, DC, Wolthuis, AM, Zimmerman, DDE

Background: The strategy of watch and wait (W&W) in patients with rectal cancer who achieve a complete clinical response (cCR) after neoadjuvant therapy is new and offers an opportunity for patients to avoid major resection surgery. However, evidence

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https://eprints.whiterose.ac.uk/133675/1/ManuscriptIWWD_V3_Final.pdf

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International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy.

Autor: El Sissy C; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France., Kirilovsky A; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France., Lagorce Pagès C; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France.; Department of Pathology, AP-HP, Georges Pompidou European Hospital, Paris, France., Marliot F; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France., Custers PA; Department of Surgery, Netherlands Cancer Institute, Antoni van Leeuwenhoek, Amsterdam, the Netherlands.; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands., Dizdarevic E; Department of Oncology, Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Sroussi M; Cordeliers Research Center, Sorbonne University, INSERM, University Paris Cité, SIRIC CARPEM, Paris, France.; Chemistry Biology Innovation Institute, BioChimie Laboratory, ESPCI, UMR8231 CNRS, University PSL, Paris, France., Castillo-Martin M; Department of Pathology, Fundação Champalimaud, Lisbon, Portugal., Haicheur N; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France., Dermani M; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France., Loche N; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France., Buttard B; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France., Musina AM; Department of Surgical Oncology, Regional Institute of Oncology (IRO), Iasi, Romania.; 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Anitei MG; 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.; Surgical Oncology Unit, Regional Institute of Oncology, Iasi, Romania., van den Berg JG; Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Broeks A; Core Facility Molecular Pathology and Biobanking, Netherlands Cancer Institute, Amsterdam, the Netherlands., Iseas S; Oncology Unit, Gastroenterology Hospital Carlos Bonorino Udaondo, Buenos Aires, Argentina., Coraglio M; Oncology Unit, Gastroenterology Hospital Carlos Bonorino Udaondo, Buenos Aires, Argentina., Loria FS; GI Clinical Oncology and GI Surgical Oncology, Instituto Alexander Fleming, Buenos Aires, Argentina., Romero A; Department of Clinical Oncology, British Hospital of Buenos Aires, Buenos Aires, Argentina., Laurent-Puig P; Cordeliers Research Center, Sorbonne University, University Paris Cité, INSERM UMR1138, Paris, France.; Department of Biology, Cancer Institute Paris CARPEM, AP-HP, Georges Pompidou European Hospital, Paris, France., de Reyniès A; Cordeliers Research Center, University Paris Cité, INSERM UMRS1138, Paris, France.; AP-HP, SeqOIA Genomic Medicine Laboratory-IT Platform, Paris, France., Fernandez LM; Colorectal Surgery, Digestive Department, Champalimaud Foundation, Lisbon, Portugal., Karoui M; Department of Digestive and Oncologic Surgery, AP-HP, Georges Pompidou European Hospital, Paris, France., Tougeron D; Department of Hepato-Gastro-Enterology and Nutritional Assistance, University Hospital of Poitiers, Poitiers, France., Vaccaro CA; Department of General Surgery, Hospital Italiano, Buenos Aires, Argentina., Santino JP; Department of General Surgery, Hospital Italiano, Buenos Aires, Argentina., Poulsen LØ; Department of Oncology, Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Lindebjerg J; Department of Oncology, Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., O'Connor JM; GI Clinical Oncology and GI Surgical Oncology, Instituto Alexander Fleming, Buenos Aires, Argentina., Scripcariu V; 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.; Surgical Oncology Unit, Regional Institute of Oncology, Iasi, Romania., Dimofte MG; Department of Surgical Oncology, Regional Institute of Oncology (IRO), Iasi, Romania.; 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Gérard JP; Department of Radiotherapy, Centre Antoine-Lacassagne, Nice, France., Chalabi M; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Figueiredo N; Colorectal Surgery, Digestive Department, Champalimaud Foundation, Lisbon, Portugal., Perez RO; Division of Colorectal Surgery, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.; Department of Surgical Oncology, Beneficencia Portuguesa Hospital, São Paulo, Brazil.; Angelita and Joaquim Gama Institute, São Paulo, Brazil., Habr-Gama A; Division of Colorectal Surgery, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.; Department of Surgical Oncology, Beneficencia Portuguesa Hospital, São Paulo, Brazil.; Angelita and Joaquim Gama Institute, São Paulo, Brazil., Galon J; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France., Hansen TF; Department of Oncology, Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Jensen LH; Department of Oncology, Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Beets G; Department of Surgery, Netherlands Cancer Institute, Antoni van Leeuwenhoek, Amsterdam, the Netherlands.; GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands., Zeitoun G; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France., Pagès F; INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.; Equipe Labellisée Ligue Contre le Cancer, Paris, France.; Cordeliers Research Center, Sorbonne University, University Paris Cité, Paris, France.; Immunomonitoring Platform, Laboratory of Immunology, Assistance Publique-Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2024 Jan 01; Vol. 42 (1), pp. 70-80. Date of Electronic Publication: 2023 Oct 03.