Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) -- a promising target for the immunotherapy of cancer.

Autor: Lopez, Vittoria, Schuh, H. J. Maximilian, Mirza, Salahuddin, Vaaßen, Victoria J., Schmidt, Michael S., Sylvester, Katharina, Idris, Riham M., Renn, Christian, Schäkel, Laura, Pelletier, Julie, Sévigny, Jean, Naggi, Annamaria, Scheffler, Björn, Sang-Yong Lee, Bendas, Gerd, Müller, Christa E.

Publikováno v: Frontiers in Immunology; 1/28/2024, p01-16, 16p

Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction.

Autor: Claff, Tobias, Schlegel, Jonathan G., Voss, Jan H., Vaaßen, Victoria J., Weiße, Renato H., Cheng, Robert K. Y., Markovic-Mueller, Sandra, Bucher, Denis, Sträter, Norbert, Müller, Christa E.

Publikováno v: Communications Chemistry; 6/1/2023, Vol. 6 Issue 1, p1-10, 10p

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Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates.

Autor: Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

Publikováno v: Angewandte Chemie International Edition; 5/23/2022, Vol. 61 Issue 22, p1-11, 11p

Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A 2A Receptor.

Autor: Claff T; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53113, Germany., Mahardhika AB; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53113, Germany.; Research Training Group 2873, University of Bonn, Bonn 53121, Germany., Vaaßen VJ; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53113, Germany., Schlegel JG; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53113, Germany., Vielmuth C; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53113, Germany., Weiße RH; Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig 04103, Germany., Sträter N; Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Leipzig 04103, Germany., Müller CE; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53113, Germany.; Research Training Group 2873, University of Bonn, Bonn 53121, Germany.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Apr 29; Vol. 7 (5), pp. 1415-1425. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024).