Zobrazeno 1 - 10
of 154
pro vyhledávání: '"VX-680"'
Autor:
Xumei Liu, Qiong Shi, Namrta Choudhry, Ting Zhang, Hong Liu, Shenqiu Zhang, Jing Zhang, Dun Yang
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12104
Small molecule inhibitors of aurora kinases are currently being investigated in oncology clinical trials. The long-term effects of these inhibitors on proliferating euploid cells have not been adequately studied. We examined the effect of the reversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8ef14ad8d4fdbb3021034a1a4a0eae
Autor:
Rong Zhao, Xiaoxia Wang, Yuan Wei, Xuewei Wang, Xiuli Wang, Jiefeng He, Junting Kou, Xiaozhong Li
Publikováno v:
Anti-Cancer Drugs. 32:969-977
Esophageal squamous cell carcinoma (ESCC) is malignant cancer with a high mortality rate. Cisplatin is one of the most potent chemotherapy agents used in the treatment of ESCC. However, chemoresistance and severe adverse effects of cisplatin become m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c112a10cf9582f6cd098e9903f3bba88
https://doi.org/10.1097/cad.0000000000001089
https://doi.org/10.1097/cad.0000000000001089
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Cellular Immunology. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d336c947ee5d15008b3e617ce0fa15dd
https://doi.org/10.33696/immunology.2.047
https://doi.org/10.33696/immunology.2.047
Akademický článek
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Autor:
John D. Minna, Michael G. Roth, Vural Tagal, Tae Hyun Hwang, David A. Wheeler, Bruce A. Posner, Adi F. Gazdar, Rolf A. Brekken, Wei Zhang, Luc Girard, Shuguang Wei, Michael A. White, Michael Peyton
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1) occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no single therapeutic agent has been identified as synthetically lethal with SMARCA4/BRG1 los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa8ccb4f10f3fbae368b01e0e25c510
https://doaj.org/article/f81ec3448b26422b8d9847f84e7abb5c
https://doaj.org/article/f81ec3448b26422b8d9847f84e7abb5c
Publikováno v:
Experimental Cell Research. 394:112112
Inhibition of Aurora-B kinase is a synthetic lethal therapy for tumors that overexpress the MYC oncoprotein. It is currently unclear whether co-occurring oncogenic alterations might influence this synthetic lethality by conferring more or less potenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a7acbff031c1dc41436dfdeec14850
https://doi.org/10.1016/j.yexcr.2020.112112
https://doi.org/10.1016/j.yexcr.2020.112112
Aurora kinase inhibitor VX‑680 suppresses the proliferation and migration of HUVECs and angiogenesis
Autor:
Shishi Niu, Chengyuan Yang, Xiaozhong Li, Zhen Zhang, Xuejiao Sun, Zichan Guo, Anyan Wang, Yuepeng Hao, Xiaoxia Wang
Publikováno v:
Molecular medicine reports. 19(5)
Angiogenesis serves a key role in tumor growth and metastasis. VX‑680, a potent inhibitor targeting the Aurora kinase family, is widely used in the inhibition of tumor progression. However, the effect of VX‑680 on angiogenesis remains unknown. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d14ced337733e7587d5aaf939b8e380
https://pubmed.ncbi.nlm.nih.gov/30816538
https://pubmed.ncbi.nlm.nih.gov/30816538
Autor:
Sam Hofmans, Vera Goossens, Koen Augustyns, Nozomi Takahashi, Lars Devisscher, Polien Claeys, Sofie Martens, Peter Vandenabeele, Marnik Vuylsteke
Publikováno v:
Cell Death & Disease
CELL DEATH & DISEASE
Cell Death and Disease
Cell Death and Disease, Vol 9, Iss 2, Pp 1-13 (2018)
CELL DEATH & DISEASE
Cell Death and Disease
Cell Death and Disease, Vol 9, Iss 2, Pp 1-13 (2018)
The Aurora kinase family (Aurora A, B and C) are crucial regulators of several mitotic events, including cytokinesis. Increased expression of these kinases is associated with tumorigenesis and several compounds targeting Aurora kinase are under evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9411c470b6f87c2e5df4ea85c17aa5da
http://europepmc.org/articles/PMC5833749
http://europepmc.org/articles/PMC5833749