Zobrazeno 1 - 10
of 1 901
pro vyhledávání: '"VSV"'
Autor:
Jeremy A. Iwashkiw, Abdulhamid O. Mohamud, Natallia Kazhdan, Aaisha Ameen, Jody E. Beecher, Carlos D. M. Filipe, Brian D. Lichty
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract One major limitation of effective vaccine delivery is its dependency on a robust cold chain infrastructure. While Vesicular stomatitis virus (VSV) has been demonstrated to be an effective viral vaccine vector for diseases including Ebola, it
Externí odkaz:
https://doaj.org/article/951f2d91d28a4889825e103f01d733a1
Autor:
Yamei Li, Yan Luo, Chao Wang, Lei Xu, Xinhua Dai, Yunfei An, Lin He, Dongmei Zeng, Yangjuan Bai, Hua Zhang
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 11 (2024)
ABSTRACT Pathogen infections remain a significant public health problem worldwide. Accumulating evidence regarding the crosstalk between bile acid (BA) metabolism and immune response reveals that BA metabolism regulates host immunity and microbial pa
Externí odkaz:
https://doaj.org/article/09038f880ab7422fb58dc990ffd990a9
Autor:
Tiancheng Hu, Yiping Liu, Jeremy Fleck, Cason King, Elaine Schalk, Zhenyu Zhang, Andrew Mehle, Judith A. Smith
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The double-stranded DNA (dsDNA) sensor STING has been increasingly implicated in responses to “sterile” endogenous threats and pathogens without nominal DNA or cyclic di-nucleotide stimuli. Previous work showed an endoplasmic reticulum (ER) stres
Externí odkaz:
https://doaj.org/article/9edb2198c6ea41b3861f589b52b66b8d
Autor:
Hitomi Kinoshita, Souichi Yamada, Takuma Ogawa, Phu Hoang Anh Nguyen, Shizuko Harada, Madoka Kawahara, Keita Ishijima, Ken Maeda, Hideki Ebihara, Shuetsu Fukushi
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Herpes B virus (BV) is a zoonotic virus and belongs to the genus Simplexvius, the same genus as human herpes simplex virus (HSV). BV typically establishes asymptomatic infection in its natural hosts, macaque monkeys. However, in humans, BV i
Externí odkaz:
https://doaj.org/article/1c35e8fa645046998f3954468b4fcb68
Autor:
Huijun Zhang, Tingli Liu, Xinhua Liu, Fenfen You, Jiaheng Yang, Nan Zhang, Ying Huang, Gaofeng Liang
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Histone deacetylates family proteins have been studied for their function in regulating viral replication by deacetylating non-histone proteins. RIG-I (Retinoic acid-inducible gene I) is a critical protein in RNA virus-induced innate antiviral signal
Externí odkaz:
https://doaj.org/article/d69f0737e6664db4b31932d00081130b
Autor:
Ha-Na Lee, Biying Xu, Aaron P. Lewkowicz, Kaliroi Engel, Logan Kelley-Baker, Ian L. McWilliams, Derek D.C. Ireland, Jennifer L. Kielczewski, Jinbo Li, Robert N. Fariss, Mercedes M. Campos, Alina Baum, Christos Kyratsous, Kristen Pascal, Chi-Chao Chan, Rachel R. Caspi, Mohanraj Manangeeswaran, Daniela Verthelyi
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105170- (2024)
Summary: Background: Ebola virus disease (EVD) survivors experience ocular sequelae including retinal lesions, cataracts, and vision loss. While monoclonal antibodies targeting the Ebola virus glycoprotein (EBOV-GP) have shown promise in improving pr
Externí odkaz:
https://doaj.org/article/22fa242296984e11a7988fdc6dae6cdd
Autor:
Adrian Schimek, Judy K.M. Ng, Ioannes Basbas, Fabian Martin, Dongyue Xin, David Saleh, Jürgen Hubbuch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101252- (2024)
Virus particle (VP) quantification plays a pivotal role in the development of production processes of VPs for virus-based therapies. The yield based on total VP count serves as a process performance indicator for evaluating process efficiency and con
Externí odkaz:
https://doaj.org/article/03bcdabe9f414401bf6445ea753ffe3c
Autor:
Chad M. Moles, Rupsa Basu, Peter Weijmarshausen, Brenda Ho, Manal Farhat, Taylor Flaat, Bruce F. Smith
Publikováno v:
Viruses, Vol 16, Iss 10, p 1641 (2024)
Vesicular stomatitis virus (VSV) is a prototype RNA virus that has been instrumental in advancing our understanding of viral molecular biology and has applications in vaccine development, cancer therapy, antiviral screening, and more. Current VSV gen
Externí odkaz:
https://doaj.org/article/2e09c825b61c4eeca5dd4c9cd9155e98
Autor:
Stacey L. P. Scroggs, Dustin A. Swanson, Taylor D. Steele, Amy R. Hudson, Lindsey M. Reister-Hendricks, Jessica Gutierrez, Phillip Shults, Bethany L. McGregor, Caitlin E. Taylor, Travis M. Davis, Nadine Lamberski, Kristen A. Phair, Lauren L. Howard, Nathan E. McConnell, Nikos Gurfield, Barbara S. Drolet, Angela M. Pelzel-McCluskey, Lee W. Cohnstaedt
Publikováno v:
Viruses, Vol 16, Iss 9, p 1428 (2024)
Vesicular stomatitis (VS) is a viral disease that affects horses, cattle, and swine that is transmitted by direct contact and hematophagous insects. In 2023, a multi-state outbreak of vesicular stomatitis New Jersey virus (VSNJV) occurred in Californ
Externí odkaz:
https://doaj.org/article/62726fd17a60491ab0a5c14d36f3035d
Autor:
Martina Mattioli, Renata A. Raele, Gunjan Gautam, Ufuk Borucu, Christiane Schaffitzel, Francesco Aulicino, Imre Berger
Publikováno v:
Viruses, Vol 16, Iss 9, p 1475 (2024)
Baculoviral vectors (BVs) derived from Autographa californica multiple nucleopolyhedrovirus (AcMNPV) are an attractive tool for multigene delivery in mammalian cells, which is particularly relevant for CRISPR technologies. Most applications in mammal
Externí odkaz:
https://doaj.org/article/db963da6dc9e487ca3ca339ecea23684