Výsledky vyhledávání - "VSMC, vascular smooth muscle cells"

The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

Autor: Kewei Wang, Zongtao Liu, Yani Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1412-1433 (2021)
Acta Pharmaceutica Sinica. B

Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca2+ activated Cl– channels (CaCCs) that are critical for physiological functions, such as epithelial secretion, smooth muscle contraction and sensory signal transduction. The attraction and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b93ad5ed1da50ffcb970b7aa59df7fe
https://doi.org/10.1016/j.apsb.2020.12.003

Zobrazit plný text záznamu

Mineralocorticoid receptor: A hidden culprit for hemodialysis vascular access dysfunction

Autor: Bohan Chen, Zhangsuo Liu, Pei Wang, Andrew S. Brem, Lance D. Dworkin, Rujun Gong

Publikováno v: EBioMedicine, Vol 39, Iss, Pp 621-627 (2019)
EBioMedicine

Hemodialysis vascular access dysfunction is a common and intractable problem in clinical practice with no definitive therapy yet available. As a key mediator of vascular and cardiac maladaptive remodeling, mineralocorticoid receptor (MR) plays a pivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3409a058643d6459439896e6c206dd
http://www.sciencedirect.com/science/article/pii/S2352396418305589

Zobrazit plný text záznamu

Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats

Autor: Edward Moreira Bahnson, Wulin Jiang, Nicholas Buglak

Publikováno v: Redox Biology, Vol 19, Iss, Pp 166-178 (2018)
Redox Biology

Atherosclerosis remains the number one cause of death and disability worldwide. Atherosclerosis is treated by revascularization procedures to restore blood flow to distal tissue, but these procedures often fail due to restenosis secondary to neointim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d487e24157c57b4e4b649494c580822
http://www.sciencedirect.com/science/article/pii/S2213231718306293

Zobrazit plný text záznamu

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release

Autor: Matthias Epple, Yana Dautova, Kevin Pappert, Alexander N. Kapustin, Martin D. Bootman, Hanneke Okkenhaug, Diane Proudfoot, Simon J. Cook, Catherine M. Shanahan

Publikováno v: Journal of Molecular and Cellular Cardiology
Dautova, Y, Kapustin, A, Pappert, K, Epple, M, Okkenhaug, H, Cook, S J, Shanahan, C M, Bootman, M D & Proudfoot, D 2017, ' Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells : A role for spleen tyrosine kinase and exosome release ', Journal of Molecular and Cellular Cardiology . https://doi.org/10.1016/j.yjmcc.2017.12.007

Aims Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d86e001074dcd1dcf16d9ed519a5db8
http://europepmc.org/articles/PMC5823844

Zobrazit plný text záznamu

Vasoconstriction triggered by hydrogen sulfide: Evidence for Na + ,K + ,2Cl - cotransport and L-type Ca 2+ channel-mediated pathway

Autor: Svetalana V. Sidorenko, Liudmila V. Smaglii, S. V. Gusakova, Svetlana V. Koltsova, Sergei N. Orlov

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 220-227 (2017)

Objectives This study examined the dose-dependent actions of hydrogen sulfide donor sodium hydrosulphide (NaHS) on isometric contractions and ion transport in rat aorta smooth muscle cells (SMC). Methods Isometric contraction was measured in ring aor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5751c584cc41446a709801851e197c2f
https://doi.org/10.1016/j.bbrep.2017.09.010

Zobrazit plný text záznamu

Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis

Autor: Nele Ferekidis, Inna Khozin-Goldberg, Irina A. Guschina, Alaa Ismail, Daryn Robert Michael, Valerie B. O'Donnell, Dipak Purshottam Ramji, John L. Harwood, Yee-Hung Chan, Sammy Boussiba, Jessica O. Williams, Hayley Gallagher, Victoria J. Tyrrell

Publikováno v: Biochimica et Biophysica Acta. Molecular Basis of Disease

Atherosclerosis and its complications are responsible for one in three global deaths. Nutraceuticals show promise in the prevention and treatment of atherosclerosis but require an indepth understanding of the mechanisms underlying their actions. A pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f07a18194f9f9cb47278ac22ed3a1ee

Zobrazit plný text záznamu

NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis

Autor: Andrey Lozhkin, Nageswara R. Madamanchi, Chandrika Canugovi, Arihiro Sumida, Takayuki Hayami, Aleksandr E. Vendrov, Marschall S. Runge

Publikováno v: Redox Biology, Vol 21, Iss, Pp-(2019)
Redox Biology

Increased reactive oxygen species (ROS) production and inflammation are key factors in the pathogenesis of atherosclerosis. We previously reported that NOX activator 1 (NOXA1) is the critical functional homolog of p67phox for NADPH oxidase activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc64e5bc1f555a6c6bc6f6ab40594235
http://www.sciencedirect.com/science/article/pii/S2213231718309765

Zobrazit plný text záznamu

Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells

Autor: Chang Hyun Byon, Jack M. Heath, Yabing Chen

Publikováno v: Redox Biology, Vol 9, Iss C, Pp 244-253 (2016)
Redox Biology

Oxidative stress represents excessive intracellular levels of reactive oxygen species (ROS), which plays a major role in the pathogenesis of cardiovascular disease. Besides having a critical impact on the development and progression of vascular patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c831f606bd6dd568819094e054115360
https://doi.org/10.1016/j.redox.2016.08.015

Zobrazit plný text záznamu

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control

Autor: Patel, J, Chuaiphichai, S, Douglas, G, Gorvin, C, Channon, K

Publikováno v: Vascular Pharmacology

G-Protein coupled receptors (GPCRs) activate intracellular signalling pathways by coupling to heterotrimeric G-proteins that control many physiological processes including blood pressure homeostasis. The Regulator of G-Protein Signalling-1 (RGS1) con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d4b7646b7f585a28f0643a5178e7bc17
http://ora.ox.ac.uk/objects/uuid:

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání