SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

Autor: Alexis Z.L. Shih, Yi-Chun Chen, Thilo Speckmann, Esben Søndergaard, Annette Schürmann, C. Bruce Verchere, Thomas E. Willnow

Publikováno v: Molecular Metabolism, Vol 65, Iss , Pp 101585- (2022)

Objective: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that S

Externí odkaz: https://doaj.org/article/794e8a6764884d43b3adb7139efce1e0

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling

Autor: Thomas E. Willnow, Eleonora Aronica, Antonino Asaro, Magda Bakun, Michal Dadlez, Tymon Rubel, Rishabhdev Sinha, Annemieke Rozeboom, Oleksandra Kalnytska, Bozena Kaminska, Anna R. Malik, Anne-Sophie Carlo-Spiewok

Publikováno v: Asaro, A, Sinha, R, Bakun, M, Kalnytska, O, Carlo-Spiewok, A S, Rubel, T, Rozeboom, A, Dadlez, M, Kaminska, B, Aronica, E, Malik, A R & Willnow, T E 2021, ' ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling ', Journal of Cell Science, vol. 134, no. 20, jcs258894 . https://doi.org/10.1242/jcs.258894
Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science, 134(20):jcs258894. Company of Biologists Ltd

Sortilin is a neuronal receptor for apolipoprotein E (apoE). Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain. This n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739701e960bdc03a27e0a11ff57d9c5b
https://pure.au.dk/ws/files/273913024/jcs258894.pdf

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