Zobrazeno 1 - 10
of 274
pro vyhledávání: '"VITO QUARANTA"'
Publikováno v:
Cancers, Vol 16, Iss 13, p 2426 (2024)
Drug tolerance is a major cause of relapse after cancer treatment. Despite intensive efforts, its molecular basis remains poorly understood, hampering actionable intervention. We report a previously unrecognized signaling mechanism supporting drug to
Externí odkaz:
https://doaj.org/article/9dd97d83326f4eeaaa82fd96058c3d7c
Autor:
Clayton M. Wandishin, Charles John Robbins, Darren R. Tyson, Leonard A. Harris, Vito Quaranta
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 358-368 (2022)
The drug-induced proliferation (DIP) rate is a metric of in vitro drug response that avoids inherent biases in commonly used metrics such as 72 h viability. However, DIP rate measurements rely on direct cell counting over time, a laborious task that
Externí odkaz:
https://doaj.org/article/4dccd14c2e2b44949ed6c76b0b027036
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105224- (2022)
Summary: Multiple intermediate epithelial-mesenchymal transition (EMT) states reflecting hybrid epithelial and mesenchymal phenotypes were observed in physiological and pathological conditions. Previous theoretical models explaining multiple EMT stat
Externí odkaz:
https://doaj.org/article/15ced98aadff48b0bceeb5cd1b1e2ad3
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The lack of a unifying metric characterizing combinatorial drug interactions has impeded the development of combinatorial therapies. Here, the authors present MuSyC, a consensus synergy metric that overcomes several caveats associated with other, pop
Externí odkaz:
https://doaj.org/article/714bcb94521f45b18fccb436c738bfea
Autor:
David Taylor, Christian T. Meyer, Diana Graves, Rupashree Sen, Juan Fu, Emily Tran, Bilal Mirza, Gabriel Rodriguez, Cara Lang, Hanwen Feng, Vito Quaranta, John T. Wilson, Young J. Kim, Michael J. Korrer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
With the clinical approval of T-cell–dependent immune checkpoint inhibitors for many cancers, therapeutic cancer vaccines have re-emerged as a promising immunotherapy. Cancer vaccines require the addition of immunostimulatory adjuvants to increase
Externí odkaz:
https://doaj.org/article/f453ae4370dd4f1f8433445990749fa7
Autor:
Vito Quaranta, Amanda Linkous
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Small Cell Lung Cancer (SCLC) is a highly aggressive, neuroendocrine tumor. Traditional reductionist approaches have proven ineffective to ameliorate the uniformly dismal outcomes for SCLC – survival at 5 years remains less than 5%. A major obstacl
Externí odkaz:
https://doaj.org/article/bb5a949813514973b3eb15c4bb847790
Autor:
Sarah M. Groves, Nicholas Panchy, Darren R. Tyson, Leonard A. Harris, Vito Quaranta, Tian Hong
Publikováno v:
Cancers, Vol 15, Iss 5, p 1477 (2023)
Small cell lung cancer (SCLC) is an aggressive cancer recalcitrant to treatment, arising predominantly from epithelial pulmonary neuroendocrine (NE) cells. Intratumor heterogeneity plays critical roles in SCLC disease progression, metastasis, and tre
Externí odkaz:
https://doaj.org/article/bee54a25541c47e78b0d12b0ff6432b3
Autor:
Corey E Hayford, Darren R Tyson, C Jack Robbins, Peter L Frick, Vito Quaranta, Leonard A Harris
Publikováno v:
PLoS Biology, Vol 19, Iss 6, p e3000797 (2021)
Tumor heterogeneity is a primary cause of treatment failure and acquired resistance in cancer patients. Even in cancers driven by a single mutated oncogene, variability in response to targeted therapies is well known. The existence of additional geno
Externí odkaz:
https://doaj.org/article/97d002547d4149c08d67d30f0550022d
Autor:
Dongya Jia, B. Bishal Paudel, Corey E. Hayford, Keisha N. Hardeman, Herbert Levine, José N. Onuchic, Vito Quaranta
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Cancer cells adjust their metabolic profiles to evade treatment. Metabolic adaptation is complex and hence better understood by an integrated theoretical-experimental approach. Using a minimal kinetic model, we predicted a previously undescribed Low/
Externí odkaz:
https://doaj.org/article/66e1a2f71e334430b77cb4dff30e193a
Autor:
David J Wooten, Sarah M Groves, Darren R Tyson, Qi Liu, Jing S Lim, Réka Albert, Carlos F Lopez, Julien Sage, Vito Quaranta
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 10, p e1007343 (2019)
Adopting a systems approach, we devise a general workflow to define actionable subtypes in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four subtypes based on global gene expression patterns and ontologies. Three c
Externí odkaz:
https://doaj.org/article/fbce162d02af49a5a07ed1284de14ab8