Zobrazeno 1 - 10
of 2 946
pro vyhledávání: '"VIRUS VECTOR"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cartilage rarely heals spontaneously once damaged. Osteoarthritis (OA) is the most common degenerative joint disease among the elderly; however, effective treatment for OA is currently lacking. Autologous chondrocyte implantation (ACI), an i
Externí odkaz:
https://doaj.org/article/c8472ec9e67840b396a4d14c38dfd213
Autor:
Mitsuo Oshimura, Toshiaki Tabata, Narumi Uno, Shuta Takata, Genki Hichiwa, Iori Kanazawa, Takeshi Endo, Kazuhisa Honma, Yayan Wang, Kanako Kazuki, Haochen Tu, Yuichi Iida, Satoshi Abe, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Human mesenchymal stem cells (hMSCs) with extended lifespan and differentiation potential that can recapitulate in vivo characteristics could significantly contribute to basic research, drug development, and cell therapy. Specifically, they
Externí odkaz:
https://doaj.org/article/d1875669cd4f4913869ea0d4478c2704
Autor:
Ute Klinkhardt, Mirjam Schunk, John Ervin, Christoph Schindler, Danny Sugimoto, Bruce Rankin, Ralf Amann, Martina Monti, Anna Kutschenko, Carsten Schumacher, Kristina Huber, Andreas Zeder, Nelli Heikkila, Arnaud M. Didierlaurent, Sylvia E. Schwarz, Madiha Derouazi
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Next-generation COVID-19 vaccines are being developed to expand the breadth of coverage against existing and future variants and to extend the duration of protection. Prime-2-CoV_Beta is an orf virus (ORFV) based multi-antigen COVID-19 vaccine that c
Externí odkaz:
https://doaj.org/article/ac42958aa7f6453581c61e1316c600ce
Autor:
Xianyong Meng, Feihu Yan, Weiqi Wang, Shen Wang, Haiyang Cong, Jiaqi Li, Yongkun Zhao, Tiecheng Wang, Nan Li, Yuwei Gao, Jianzhong Wang, Na Feng, Xianzhu Xia
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Rabies, caused by the Rabies virus (RABV), is a highly fatal zoonotic disease. Existing rabies vaccines have demonstrated good immune efficacy, but the complexity of immunization procedures and high cost has impeded the elimination of RABV, particula
Externí odkaz:
https://doaj.org/article/8edd97d02b774a0d88aabd7932d2e89e
Autor:
Kazuto Kimura, Masaya Tsukamoto, Hiroko Sugisaki, Miyuu Tanaka, Mitsuru Kuwamura, Yuki Matsumoto, Genki Ishihara, Kei Watanabe, Mika Okada, Mahito Nakanishi, Kikuya Sugiura, Shingo Hatoya
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 708-716 (2024)
Companion animals, such as felines and canines, could provide an excellent platform for translational research from veterinary to human medicine. However, the use of feline induced pluripotent stems (fiPSCs) of quality in basic or clinical research h
Externí odkaz:
https://doaj.org/article/1d90ec70e8ce495bb603d67d954053e1
Publikováno v:
PeerJ, Vol 12, p e18211 (2024)
Background Hibiscus mutabilis L. is a popular regional characteristic plant in China, cultivated for its attractive flower colors, extended bloom time, and medicinal properties. To enhance molecular breeding and gene function studies, we conducted tr
Externí odkaz:
https://doaj.org/article/2ff21065621c4e5d93f27c4a1deb6d4f
Autor:
Janina Behrens, Ingke Braren, Michelle Y. Jaeckstein, Luka Lilie, Markus Heine, Finnja Sass, Judith Sommer, Dagmar Silbert-Wagner, Marceline M. Fuh, Anna Worthmann, Leon Straub, Tarek Moustafa, Joerg Heeren, Ludger Scheja
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 101999- (2024)
Objective: Recombinant adeno-associated virus (rAAV) vectors are powerful tools for the sustained expression of proteins in vivo and have been successfully used for mechanistic studies in mice. A major challenge associated with this method is to obta
Externí odkaz:
https://doaj.org/article/107161de55d9488bb70aeb07ce4f4045
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 9, Pp n/a-n/a (2024)
Abstract Background Mycoplasma pneumoniae (MP) is a common respiratory pathogen affecting the longevity of the elderly and the health of children. However, the human vaccine against MP has not been successfully developed till now due to the poor immu
Externí odkaz:
https://doaj.org/article/e9ab426a187b4d37a20b6b7bfd7d5fc2
Autor:
Cassie Ables, Catalina Jaramillo, E. Lynne Wood, Sara Stern, Mouied Alashari, Linda Book, Russell J. Butterfield
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101296- (2024)
Spinal muscular atrophy is a neurodegenerative disorder resulting from the irreversible loss of anterior horn cells secondary to homozygous mutations in the survival motor neuron gene SMN1. Gene replacement therapy using a recombinant adeno-associate
Externí odkaz:
https://doaj.org/article/9204f23b517840c0b4a564e32d46d24b