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pro vyhledávání: '"VICTOR DE LA ROSA"'
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Publikováno v:
Pflügers Archiv - European Journal of Physiology. 474:721-732
KCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and 5. Activation of these channels silence the neurons, limiting action potential duration and preventing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d4fd46d1e7e6c3066c54ffc4de3be5
https://doi.org/10.1007/s00424-022-02692-w
https://doi.org/10.1007/s00424-022-02692-w
Autor:
Juan Jose Romero-Tovar, Alejandro Rafael Medina-Vilchis, Adrian Rivera-Ruedas, Victor De la Rosa
Publikováno v:
Biophysical Journal. 122:512a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8c3e097223944f1af83011dcaf42186
https://doi.org/10.1016/j.bpj.2022.11.2724
https://doi.org/10.1016/j.bpj.2022.11.2724
Autor:
Alexander B. Taylor, Victor De la Rosa, Benjamin T. Enslow, Akash Bhattacharya, Mark S. Shapiro, Crystal R. Archer
Publikováno v:
Journal of Biological Chemistry. 294:6094-6112
Calmodulin (CaM) conveys intracellular Ca2+ signals to KCNQ (Kv7, “M-type”) K+ channels and many other ion channels. Whether this “calmodulation” involves a dramatic structural rearrangement or only slight perturbations of the CaM/KCNQ comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21dce14a9eb25ade46c2a5794a67e704
https://doi.org/10.1074/jbc.ra118.006857
https://doi.org/10.1074/jbc.ra118.006857
Publikováno v:
Journal of Biological Chemistry. 293:19411-19428
Phosphatidylinositol 4,5-bisphosphate (PIP2) in the plasma membrane regulates the function of many ion channels, including M-type (potassium voltage-gated channel subfamily Q member (KCNQ), Kv7) K+ channels; however, the molecular mechanisms involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::657f6eae029bc50495ceed235dc3503a
https://doi.org/10.1074/jbc.ra118.005401
https://doi.org/10.1074/jbc.ra118.005401
Autor:
Victor De La Rosa, Ian Scott Ramsey
Publikováno v:
Biophysical Journal. 114:2844-2854
The Hv1 proton channel shares striking structural homology with fourth transmembrane helical segment-type voltage-sensor (VS) domains but manifests distinctive functional properties, including a proton-selective “aqueous” conductance and alloster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e43e0e0fda9de8f76f76fb31e8a8d94
https://doi.org/10.1016/j.bpj.2018.04.049
https://doi.org/10.1016/j.bpj.2018.04.049
Publikováno v:
The Journal of General Physiology
Hv1 proteins form a voltage-gated proton channel that is inhibited by extracellular Zn2+. De La Rosa et al find that extracellular Zn2+ is octahedrally coordinated by specific protein atoms and that Zn2+ occupancy modulates voltage sensor activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c12c8cf6df2a4701f98c9684008feec
https://doi.org/10.1085/jgp.201711822
https://doi.org/10.1085/jgp.201711822
Autor:
Victor De la Rosa, Mark S. Shapiro
Publikováno v:
Biophysical Journal. 118:588a-589a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f36a9cf41131b3d66e0979c4117a3d51
https://doi.org/10.1016/j.bpj.2019.11.3190
https://doi.org/10.1016/j.bpj.2019.11.3190
Autor:
Crystal R, Archer, Benjamin T, Enslow, Alexander B, Taylor, Victor, De la Rosa, Akash, Bhattacharya, Mark S, Shapiro
Publikováno v:
The Journal of biological chemistry. 294(15)
Calmodulin (CaM) conveys intracellular Ca(2+) signals to KCNQ (Kv7, “M-type”) K(+) channels and many other ion channels. Whether this “calmodulation” involves a dramatic structural rearrangement or only slight perturbations of the CaM/KCNQ co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::527bc3466826e79ec5e4b91ff5955c2f
https://pubmed.ncbi.nlm.nih.gov/30808708
https://pubmed.ncbi.nlm.nih.gov/30808708