Zobrazeno 1 - 10
of 51
pro vyhledávání: '"VH replacement"'
Autor:
Franziska Darzentas, Monika Szczepanowski, Michaela Kotrová, Alina Hartmann, Thomas Beder, Nicola Gökbuget, Stefan Schwartz, Lorenz Bastian, Claudia Dorothea Baldus, Karol Pál, Nikos Darzentas, Monika Brüggemann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe malignant transformation leading to a maturation arrest in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) occurs early in B-cell development, in a pro-B or pre-B cell, when somatic recombination of variable (V), diversity (D)
Externí odkaz:
https://doaj.org/article/13211689f07d4864a94f776d95537531
Autor:
Adel Gazizova, Andrey Zolotarev, Vladislav Myrov, Anastasiya Vinogradova, Aleksandr Cheblokov, Evgeny Bakin, Oksana Stanevich
Publikováno v:
Proceedings of the XXth Conference of Open Innovations Association FRUCT, Vol 426, Iss 22, Pp 48-54 (2018)
In this project an open source tool for discovery and analysis of abnormal immunoglobulin genes rearrangements was developed. The main goal is in finding so-called “footprints” - small parts of incompletely rearranged V-segments in IGH genes. Joi
Externí odkaz:
https://doaj.org/article/910845a564494b469fd0fa55baf8fa36
Autor:
Kumar, Rashmi, Bach, Martina P., Mainoldi, Federica, Maruya, Mikako, Kishigami, Satoshi, Jumaa, Hassan, Wakayama, Teruhiko, Kanagawa, Osami, Fagarasan, Sidonia, Casola, Stefano
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2015 Feb 01. 112(5), E450-E457.
Externí odkaz:
https://www.jstor.org/stable/26461469
Autor:
Sun, Amy, Novobrantseva, Tatiana I., Coffre, Maryaline, Hewitt, Susannah L., Jensen, Kari, Skok, Jane A., Rajewsky, Klaus, Koralov, Sergei B.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2015 Feb 01. 112(5), E458-E466.
Externí odkaz:
https://www.jstor.org/stable/26461470
Akademický článek
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Autor:
Zhixin (Jason) eZhang
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
VH replacement refers to RAG-mediated secondary recombination of the IgH genes, which renews almost the entire VH gene coding region but retains a short stretch of nucleotides as a VH replacement footprint at the newly generated VH-DH junction. To ex
Externí odkaz:
https://doaj.org/article/aa64af3b83fc430098899588424b0bc8
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
The VH replacement process is a RAG-mediated secondary recombination in which the variable region of a rearranged VHDJH is replaced by a different germline VH gene. In almost all human and mouse VH genes, two sequence features appear to be crucial fo
Externí odkaz:
https://doaj.org/article/a388b3d532fb4227a3b47d01eb1cbce0
Autor:
Lei eYu, Yongjun eGuan
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
A large panel of potent broadly neutralizing antibodies (bnAbs) against HIV-1 has been reported in recent years, raising hope for the design of an effective vaccine based on epitopes recognized by these protective antibodies. However, many of these b
Externí odkaz:
https://doaj.org/article/a71f03835a8a4843ab61be96bd646ca7
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
VH replacement occurs through RAG-mediated secondary recombination between a rearranged VH gene and an upstream unrearranged VH gene. Due to the location of the cryptic Recombination Signal Sequence (cRSS, TACTGTG) at the 3’ end of VH gene coding r
Externí odkaz:
https://doaj.org/article/91028a036ad2430f9ce010c725e4edb3
Autor:
Wenzhao eMeng, Sahana eJayaraman, Zhang eBochao, Gregory W. Schwartz, Robert eDaber, Uri eHershberg, Alfred eGarfall, Christopher S Carlson, Eline T. Luning Prak
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
VH replacement is a type of antibody gene rearrangement in which an upstream heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In this Hypothesis and Theory article, we begin by reviewing the mechanism of VH replaceme
Externí odkaz:
https://doaj.org/article/25589416ef3e40c8bd8c47c1728685b3