Metal complexes of 3-(4-bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone: cytotoxic activity and investigation on the mode of action of the gold(III) complex

Autor: Jonas Pereira Ramos, Silvia Castelli, Luciana B.P. Sâmia, Alessandro Desideri, Venn Vutey, Elaine M. Souza-Fagundes, Jeferson G. Da Silva, Heloisa Beraldo, Gabrieli L. Parrilha

Publikováno v: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 29(3)

Complexes [Au(PyCT4BrPh)Cl]Cl (1), [Pt(PyCT4BrPh)Cl]0.5KCl (2), and [Pd(PyCT4BrPh)Cl]KCl (3) were obtained with 3-(4-bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone (HPyCT4BrPh). Although complexes (2) and (3) did not exhibit potent cyto

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https://pubmed.ncbi.nlm.nih.gov/27091443

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Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B.

Autor: Velásquez AMA; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil.; São Paulo State University (UNESP), Institute of Chemistry, Araraquara, Brazil., Ribeiro WC; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil., Venn V; University of Rome, Tor Vergata, Rome, Italy., Castelli S; University of Rome, Tor Vergata, Rome, Italy., Camargo MS; University of Rome, Tor Vergata, Rome, Italy., de Assis RP; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil., de Souza RA; São Paulo State University (UNESP), Institute of Chemistry, Araraquara, Brazil., Ribeiro AR; Campinas State University (UNICAMP), Biology Institute, Campinas, Brazil., Passalacqua TG; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil.; São Paulo State University (UNESP), Institute of Chemistry, Araraquara, Brazil., da Rosa JA; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil., Baviera AM; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil., Mauro AE; São Paulo State University (UNESP), Institute of Chemistry, Araraquara, Brazil., Desideri A; University of Rome, Tor Vergata, Rome, Italy., Almeida-Amaral EE; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil., Graminha MAS; São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Brazil graminha@fcfar.unesp.br.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Jul 25; Vol. 61 (8). Date of Electronic Publication: 2017 Jul 25 (Print Publication: 2017).