Zobrazeno 1 - 10
of 964
pro vyhledávání: '"VEGF signaling"'
Autor:
Kento Morozumi, Yoshihide Kawasaki, Tomonori Sato, Masamitsu Maekawa, Shinya Takasaki, Shuichi Shimada, Takanari Sakai, Shinichi Yamashita, Nariyasu Mano, Akihiro Ito
Publikováno v:
Metabolites, Vol 14, Iss 3, p 170 (2024)
Tyrosine kinase inhibitors (TKIs) play a crucial role in the treatment of advanced renal cell carcinoma (RCC). However, there is a lack of useful biomarkers for assessing treatment efficacy. Through urinary metabolite analysis, we identified the meta
Externí odkaz:
https://doaj.org/article/d60a018b8766448785e64fb45053e49c
Akademický článek
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Autor:
Hongtao Tan, Junxian Chen, Yicong Li, Yingshan Li, Yunchang Zhong, Guangzhao Li, Lingling Liu, Yiqun Li
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-20 (2022)
Abstract Background Glabridin (Glab) is a bioactive component of licorice that can ameliorate diabetes, but its role in diabetic nephropathy (DN) has seldom been reported. Herein, we explored the effect and underlying mechanism of Glab on DN. Methods
Externí odkaz:
https://doaj.org/article/a8c4fb595d5749abbf777d170cef028d
Autor:
Annalisa Schirizzi, Marialessandra Contino, Livianna Carrieri, Chiara Riganti, Giampiero De Leonardis, Maria Principia Scavo, Maria Grazia Perrone, Morena Miciaccia, Joanna Kopecka, Maria Grazia Refolo, Claudio Lotesoriere, Nicoletta Depalo, Federica Rizzi, Gianluigi Giannelli, Caterina Messa, Rosalba D’Alessandro
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionPaclitaxel (PTX) interferes with microtubule architecture by binding to β-tubulin, thereby blocking progression at the G2/M phase and inducing apoptosis. This study aimed to investigate molecular processes underlying PTX-mediated resista
Externí odkaz:
https://doaj.org/article/22198d209df840f1b9636ba624d8c711
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113288- (2022)
Current therapy for ischemic stroke primarily relies on tissue plasminogen activator (tPA), but it is limited by narrow treatment time window, bleeding complications and neurotoxicity. The preliminary study of tPA plus Danhong injection (DHI) shows t
Externí odkaz:
https://doaj.org/article/6560dfc3592e4e69b81ccbdcebc0e041
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 939 (2023)
Bevacizumab (Avastin) is a vascular endothelial growth factor (VEGF) inhibitor that is widely used for aggressive posterior retinopathy of prematurity (APROP). Its use is associated with multiple adverse effects. Aflibercept (Eylea) is a VEGFR-1 anal
Externí odkaz:
https://doaj.org/article/f061bfbea46a4505a16aef5046eff2dd
Autor:
Pengyu Fu, Rongxin Zhu, Jie Jia, Yang Hu, Chengjun Wu, Pawel Cieszczyk, Hans-Christer Holmberg, Lijing Gong
Publikováno v:
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-14 (2021)
Abstract Background High-fat diet (HFD)-induced obesity causes immune cells to infiltrate adipose tissue, leading to chronic inflammation and metabolic syndrome. Brown adipose tissue (BAT) can dissipate the energy produced by lipid oxidation as heat,
Externí odkaz:
https://doaj.org/article/64be9e94528349ddb435a42af1660be6
Akademický článek
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Publikováno v:
Guoji Yanke Zazhi, Vol 19, Iss 5, Pp 762-765 (2019)
Choroid neovascularization is the characteristic pathological change of many fundus diseases and is the most common cause for severe vision loss and metamorphopsia. Among the pathogenic factors, VEGF is considered to be the most important and treatme
Externí odkaz:
https://doaj.org/article/65b585f16e0046ae8e601b14c6d8455c
Autor:
Pieter R. Norden, Tsutomu Kume
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
The lymphatic system is essential for lipid absorption/transport from the digestive system, maintenance of tissue fluid and protein homeostasis, and immune surveillance. Despite recent progress toward understanding the cellular and molecular mechanis
Externí odkaz:
https://doaj.org/article/423aff251d644d66abd39c2ce80576d2