Zobrazeno 1 - 10
of 38
pro vyhledávání: '"VDP::Matematikk og naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448"'
Autor:
Hymonti Dey, Danijela Simonovic, Ingrid Norberg-Schulz Hagen, Terje Vasskog, Elizabeth G. Aarag Fredheim, Hans-Matti Blencke, Trude Anderssen, Morten B. Strøm, Tor Haug
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13844
We have synthesised short analogues of the marine antimicrobial peptide Turgencin A from the colonial Arctic ascidian Synoicum turgens. In this study, we focused on a central, cationic 12-residue Cys-Cys loop region within the sequence. Modified (try
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e0f86fb7635e0ad6aaccbb6c576b18
https://pubmed.ncbi.nlm.nih.gov/36430320
https://pubmed.ncbi.nlm.nih.gov/36430320
Autor:
Zhu, Bangfu, Parsons, Tom A, Stensen, Wenche, Mjøen Svendsen, John S, Fugelli, Anders, Hodge, James J L
Publikováno v:
Zhu, B, Parsons, T A, Stensen, W, Mjøen Svendsen, J S, Fugelli, A & Hodge, J J L 2022, ' DYRK1a inhibitor mediated rescue of Drosophila models of Alzheimer’s disease-Down Syndrome phenotypes ', Frontiers in Pharmacology, vol. 13, 881385 . https://doi.org/10.3389/fphar.2022.881385
Alzheimer’s disease (AD) is the most common neurodegenerative disease which is becoming increasingly prevalent due to ageing populations resulting in huge social, economic, and health costs to the community. Despite the pathological processing of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fe4e1bd0be601c5d280db3add76d49
https://hdl.handle.net/10037/26607
https://hdl.handle.net/10037/26607
Autor:
Dyrendalsli, Maja Bele
The cysteine of HCD (C286) in DYRK1A is involved in disulfide bridge formation with a cysteine (C312) in the DFGSSC sequence. The purpose of this project was to investigate how the state of the disulfide bridge would affect enzyme catalytic and ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=nora_uio__no::b3bc0131555dac95b29e91d24bef0fdb
https://hdl.handle.net/10037/26589
https://hdl.handle.net/10037/26589
Autor:
Langer, Manuel Karl
Natural products (NPs) have been the major source for the development of new small molecule drugs in modern medicine. Despite NPs being so prominent, marine natural products (MNPs) and derivatives thereof are hardly found in clinically approved agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6a54b0c5398dfddb2221df74d1743b1b
https://hdl.handle.net/10037/26041
https://hdl.handle.net/10037/26041
Autor:
Manuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Francesco Zilioli, Tor Haug, Hans-Matti Blencke, Klara Stensvåg, Morten B. Strøm, Annette Bayer
Publikováno v:
European Journal of Medicinal Chemistry. 241:114632
An amphipathic barbiturate mimic of the marine eusynstyelamides is reported as a promising class of antimicrobial agents. We hereby report a detailed analysis of the structure-activity relationship for cationic amphipathic N,N′ -dialkylated-5,5-dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9160fcfce483db116bf350bd267febfa
https://doi.org/10.1016/j.ejmech.2022.114632
https://doi.org/10.1016/j.ejmech.2022.114632
Autor:
Clémence Lauga, Kah Ni Tan, Magne O. Sydnes, Emily K Kennedy, Ida T. Urdal Helgeland, Vicky M. Avery, Marte Albrigtsen, Katja S. Håheim, Jeanette Hammer Andersen, Théodora Matringe, Emil Lindbäck
Publikováno v:
Molecules
Volume 26
Issue 11
Molecules, Vol 26, Iss 3268, p 3268 (2021)
Volume 26
Issue 11
Molecules, Vol 26, Iss 3268, p 3268 (2021)
A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e84b93eb7f48520da5b5dfe21f11247
Autor:
Jawad, Jawad
From previous work, it was identified two analytes of interest, produced by Lacinutrix sp. The two analytes are iso-branched lyso-ornithine lipids with only one CH2 group differing between the two compounds, in the hydrocarbon chain (lysoC15:0 and C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cdfb6cfa3544cf0e1de4953358b6cd42
https://hdl.handle.net/10037/22724
https://hdl.handle.net/10037/22724
Autor:
Sengee, Myagmarsuren
Many of the anticancer compounds discovered through synthesis or bioprospecting activities are found to be equally toxic to healthy cells and tumors. Consequently, these compounds are not considered as promising drug candidates worthy of further stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::03f4850c0ec1d0840cb39eeea4c3ff8b
https://hdl.handle.net/10037/26773
https://hdl.handle.net/10037/26773
Autor:
Schneider, Yannik Karl-Heinz
The thesis gives an introduction to natural product drug discovery and the underlying chemical principles that make natural products privileged structures for drug discovery. Paper I deals with the isolation of Lipid 430 from cultures of two Algibact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::45f385ede501e550af34a2fcaccb50a0
https://hdl.handle.net/10037/19264
https://hdl.handle.net/10037/19264
Autor:
Dominik Ausbacher, Johanna U. Ericson Sollid, Terkel Hansen, Marianne Hagensen Paulsen, Annette Bayer, Tor Haug, Magnus Engqvist, Morten B. Strøm, Trude Anderssen, Jeanette Hammer Andersen
Source at https://doi.org/10.1016/j.ejmech.2019.111671. The rapid emergence and spread of multi-resistant bacteria have created an urgent need for new antimicrobial agents. We report here a series of amphipathic α,α-disubstituted β-amino amide der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e52239e41a7ff50a8b7b5706d8fdef1
https://hdl.handle.net/10037/16259
https://hdl.handle.net/10037/16259