Sustained intra-articular delivery of IL-1Ra from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis

Autor: KA Kimmerling, BD Furman, DS Mangiapani, MA Moverman, SM Sinclair, JL Huebner, A Chilkoti, VB Kraus, LA Setton, F Guilak, SA Olson

Publikováno v: European Cells & Materials, Vol 29, Pp 124-140 (2015)

Post-traumatic arthritis (PTA) is a rapidly progressive form of arthritis that develops due to joint injury, including articular fracture. Current treatments are limited to surgical restoration and stabilization of the joint; however, evidence sugges

Externí odkaz: https://doaj.org/article/8b17c52a17084fe9827e11567f17beb3

The CALERIE Genomic Data Resource.

Autor: Ryan CP; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. cpr2139@cumc.columbia.edu., Corcoran DL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Banskota N; Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, USA., Eckstein Indik C; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA., Floratos A; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA., Friedman R; Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA., Kobor MS; BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Colombia, Canada.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Colombia, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, British Colombia, Canada.; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.; Edwin S. H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, British Colombia, Canada., Kraus VB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC, USA., Kraus WE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC, USA., MacIsaac JL; Centre for Molecular Medicine and Therapeutics, Vancouver, British Colombia, Canada., Orenduff MC; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Pieper CF; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., White JP; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC, USA., Ferrucci L; Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, USA., Horvath S; Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Huffman KM; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC, USA., Belsky DW; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. db3275@cumc.columbia.edu.; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA. db3275@cumc.columbia.edu.

Publikováno v: Nature aging [Nat Aging] 2024 Dec 13. Date of Electronic Publication: 2024 Dec 13.

Immune System-Related Plasma Pathogenic Extracellular Vesicle Subpopulations Predict Osteoarthritis Progression.

Autor: Zhang X; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27701, USA., Ma S; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455, USA., Naz SI; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455, USA., Soderblom EJ; Duke Proteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC 27701, USA., Jain V; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA., Aliferis C; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455, USA., Kraus VB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27701, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 21; Vol. 25 (23). Date of Electronic Publication: 2024 Nov 21.

Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change.

Autor: Ma S; Institute for Health Informatics (IHI), Academic Health Center, University of Minnesota, Minneapolis, MN 55455., Morris MC; Center for Clinical Systems Biology, Rochester General Hospital, Rochester, NY 14621., Hubal MJ; Department of Kinesiology, Indiana University - Indianapolis, Indianapolis IN 46202., Ross LM; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701., Huffman KM; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701., Vann CG; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701., Moore N; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701., Hauser ER; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701.; Department of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine, Durham, NC 27701., Bareja A; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701., Jiang R; Department of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine, Durham, NC 27701., Kummerfeld E; Institute for Health Informatics (IHI), Academic Health Center, University of Minnesota, Minneapolis, MN 55455., Barberio MD; Department of Exercise and Nutrition Sciences, George Washington University, Washington DC 20052., Houmard JA; Department of Kinesiology, ECU, Greenville, NC 27858., Bennett WB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701., Johnson JL; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701., Timmons JA; School of Medicine and Dentistry, Queen Mary University of London, UK., Broderick G; Center for Clinical Systems Biology, Rochester General Hospital, Rochester, NY 14621., Kraus VB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701., Aliferis CF; Institute for Health Informatics (IHI), Academic Health Center, University of Minnesota, Minneapolis, MN 55455., Kraus WE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Sep 08. Date of Electronic Publication: 2024 Sep 08.

Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study.

Autor: Lv Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China., Zhang Y; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Li X; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China., Gao X; Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, China., Ren Y; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Deng L; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Xu L; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Big Data in Health Science, School of Public Health, Zhejiang University, Hangzhou, China., Zhou J; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China., Wu B; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China., Wei Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China., Cui X; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China., Xu Z; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China., Guo Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China., Qiu Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Big Data in Health Science, School of Public Health, Zhejiang University, Hangzhou, China., Ye L; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Chen C; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China., Wang J; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China., Li C; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, China., Luo Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, China., Yin Z; Division of Non-Communicable Disease and Healthy Aging Management, Chinese Center for Disease Control and Prevention, Beijing, China., Mao C; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China., Yu Q; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China., Lu H; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Kraus VB; Department of Medicine, Duke Molecular Physiology Institute and Division of Rheumatology, Duke University School of Medicine, Durham, NC, USA., Zeng Y; Center for Study of Healthy Aging and Development Studies, Peking University, Beijing, China., Tong S; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.; School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia., Shi X; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing 100021, China.

Publikováno v: European heart journal [Eur Heart J] 2024 Jun 28; Vol. 45 (24), pp. 2145-2154.